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| 1 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 2 | Stiffness and elastic behavior of human intracranial and extracranial arteries显示文摘 | Hayashi K Handa H Nagasawa S | 1980 | Journal of Biomechanics1980，13，： | 2 |
| 3 | Proteins associate with adaptation of cultured tobacco cells to NaCl显示文摘 | Sing N K Handa A K Hasegawa P M | 1985 | Plant Physiol1985，79，： | 2 |
| 4 | Senescence-associated beta-galactosidase histochemistry for the primate eye显示文摘 | Mishima K Handa JT Aotaki-Keen A | 1999 | Invest Ophthalmol Vis Sci1999，40，7： | 1 |
| 5 | Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells显示文摘 | KOJIMA N HANDA K NEWMAN W | 1992 | Biochem Biophys Res Commun1992，182，3： | 1 |
| 6 | Mechanism for inhi- bition of influenza virus RNA polymerase activity by matrix pro- tein 显示文摘 | Watanabe K Handa H Mizumoto K | 1996 | J Virol1996，70，： | 1 |
| 7 | Heat-induced egg white gels as affected by pH显示文摘 | Handa A Takahashi K Kuroda N | | 0，，63： | 1 |
| 8 | ProteirLs associated with adaptation of cultured tobacco cells to NaCI显示文摘 | SINGH N K HANDA A K HASIA P M | 1985 | Plant Physiology1985，79，1： | 1 |
| 9 | Immune function in patients with acute pancreatitis显示文摘 | Uehara S Gothoh K Handa H | 2003 | J Gastroenterol Hepatol2003，18，4： | 1 |
| 10 | Molecular cloning of a ripening-specifi lipoxygenase and its expression during wild-type and mutant tomato fruit development显示文摘 | KAUSCH K D HANDA A K | 1997 | Plant Physiol1997，113，4： | 1 |
| 11 | Immune thnction in patients with acute panereatitis 显示文摘 | UEHARA S GOTHOH K HANDA H | 2003 | J Gastroenterol Hepatol2003，18，4： | 1 |
| 12 | Hormonal regulation of tomato fruit development:a molecular perspective显示文摘 | Srivastava A Handa A K | 2005 | Journal of Plant Growth Regulation2005，24，2： | 1 |
| 13 | HRCT features of intersti- tial lung disease in dermatomyosltis with anti-CADM-140 antibody 显示文摘 | Tanizawa K Handa T Nakashinm R | 2011 | Respir Med2011，105，9： | 1 |
| 14 | 显示文摘 | Handa K Peng S T Tamir T | 1975 | Applied Physics1975，，1： | 1 |
| 15 | Adventitial delivery of platelet-derivedendothelial cell growth factor gene prevented intimal hyperplasia of veingraft显示文摘 | Handa M Li W Morioka K | 2008 | J Vase Surg2008，48，6： | 1 |
| 16 | Progenitor cells from dental follicle are able to form cementum matrix in vivo显示文摘 | Handa K Saito M Tsunoda A | 2002 | Connect Tissue Res2002，43，23： | 1 |
| 17 | Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines显示文摘 | Guan F Handa K Hakomori S | | 0，，： | 1 |
| 18 | Pretreatment with low- energy shock waves reduces the renal oxidative stress and inflammation caused by high-energy shock wave lithotripsy显示文摘 | Clark D L Connors B A Handa R K | 2011 | Urol Res2011，39，： | 1 |
| 19 | Biomechanical study of the constitutive laws of vascular wall显示文摘 | Hayashi K Sato M Handa H | 1979 | Exp Mechanics1979，14，： | 1 |
| 20 | Esophageal motility and psychiatric factors in functional dyspepsia patients with or without pain显示文摘 | Mine K Yamamoto H | 1999 | Dig Dis Sci1999，44，10： | 1 |
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