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| 1 | Glypican-3和CD34免疫组化染色在肝细胞癌与良性肝细胞性病变鉴别诊断中的价值显示文摘 | Coston W M P Loera S Lau S K 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，3： | 31 |
| 2 | Dietary factors and smoking as risk factors for PD in a rural population in China: a nested case-control study显示文摘 | Ma L Zhang L Gao XH Chen W Wu YP Wang Y Li XF Como P Kieburtz K Qiao YL | 2006 | 中国生物学文摘2006，20，8： | 13 |
| 3 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 4 | 查看详情显示文摘 | W C Huang H Y Tam P K A Wai X Y Dong H Ming J P Xie | | 中国物理快报(英文版)0，，： | 4 |
| 5 | Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation显示文摘Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation. | Darin S Krygier Urs P Steinbrecher Martin Petric Siegfried R Erb Stephen W Chung Charles H Scudamore Andrzej K Buczkowski Eric M Yoshida | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 6 | 气肿性肾盂肾炎的肾部分切除术与肾保留术的比较显示文摘 | Bum S P Sun-Ju L Youm W K 张鸣(译) 陈朝晖(校) | 2006 | 临床泌尿外科杂志2006，21，10： | 3 |
| 7 | 富含组织细胞型横纹肌母细胞肿瘤:一种组织学独特的横纹肌母细胞肿瘤显示文摘许多软组织肿瘤不能简单地划分为“良性”或“恶性”。WHO软组织和骨肿瘤分类将几种类型的软组织肿瘤(如脂肪细胞肿瘤中的非典型脂肪瘤性肿瘤和内皮细胞肿瘤中的血管内皮瘤)确定为中间型(交界型)。一些软组织肿瘤(如韧带样型纤维瘤病和含铁血黄素沉着性纤维脂肪瘤性肿瘤)被认为是中度恶性肿瘤,这可能是因为它们具有局部侵袭性生长的能力,也可能因为它们(如血管瘤样纤维组织细胞瘤和骨化性纤维黏液样肿瘤)具有较低但无法预测的远处转移风险。血管球肿瘤和PEComa等肿瘤的分类系统不仅可以预测临床良、恶性肿瘤具有合理的敏感性和特异性,而且还可以将这些肿瘤的少部分划分为恶性潜能不确定型。有选择的软组织肿瘤(如胃肠道间质肿瘤和孤立性纤维性肿瘤),应从风险评估的角度来看待,而非良、恶性。显示骨骼肌分化的肿瘤传统上一分为二为良性横纹肌瘤或完全恶性横纹肌肉瘤(RMS)。 | Martinez A P Fritchie K J Weiss S W 张仁亚 | 2019 | 临床与实验病理学杂志2019，35，11： | 3 |
| 8 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 9 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 10 | Rume acid: a proposed common name for the major conjugated linoleic acid isomer food in nature products显示文摘 | Kramer J K G Parodi P W Tensen R G | 1998 | Lipids1998，33，8： | 2 |
| 11 | Percutaneous balloon mitral valvuloplasty in patients with mitral restenosis after previous surgical commissurotomy: a matched comparative study显示文摘 | LAU K W DING Z P GAO W | 1996 | Eur Heart J1996，17，9： | 2 |
| 12 | Modified ZehnerSchlunder models for stagnant thermal conductivity of porous media 显示文摘 | Hsu C T Cheng P Wong K W | 1994 | Int J Heat Mass Transfer1994，37，17： | 2 |
| 13 | A lumped-parameter model for stagnant thermal conductivity of spatially periodic porous media 显示文摘 | Hsu C T Cheng P Wong K W | 1995 | J Heat Transfer1995，177，： | 2 |
| 14 | The directly heating LaB6 cathodes显示文摘 | LUNG K N PINCOSY P A EHLERS K W | 1986 | Rev Sci Instrum1986，57，7： | 2 |
| 15 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 16 | Monitoring urea levels during haemodialysis with a pulsed-flow chemiluminescence analyser显示文摘 | Lewisa S W Francisa P S Lima K F | 2002 | Anal Chim Acta2002，461，1： | 2 |
| 17 | 深部地球条件下铁和氧元素的化学变化显示文摘氧与铁分别为地球上丰度最高的元素与占地球质量最大的元素,它们所形成的化合物遍布我们的星球,具有-2价的氧控制着地球的氧逸度,随着深度的增加氧逸度逐渐降低,与铁所形成的氧化物中铁的价态也逐渐降低,O/Fe逐渐增加,近些年来科学家们发现深部地球条件下铁的一系列氧化物,其中具有高压黄铁矿结构的铁超氧化物FeO2具有最高的O/Fe,并且它还能够携带一定量的H(表示为Py-FeO2H,, x=0-1)。 | 夏群科 Liu J Hu Q Y Bi W L Yang L X Xiao Y M Chow P Meng Y.Prakapenka V B Mao H K Mao W L | 2019 | 矿物岩石地球化学通报2019，38，3： | 2 |
| 18 | 查看详情显示文摘 | W S Duan K P Lu J B Zhao | | 0，，： | 2 |
| 19 | Effect of planar anisotropy on wrinkle formation tendencies in curved sheets 显示文摘 | TUGCUA P NEALE K W | 2001 | International Journal of Mechanical Sciences2001，43，3： | 2 |
| 20 | In situ spectroscopic investigations of adsorption mechanisms of nitroaromatic compounds at clay minerals显示文摘 | Weissmahr K W Haderlein S B Schwarzenbach R P | 1997 | Environ Sci Technol1997，31，： | 2 |
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