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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | 厚壁奥氏体焊缝超声波检测之探究(英文)显示文摘由于奥氏体焊缝中材料性能的各向异性和微观组织结构的不同,奥氏体焊缝的超声波检测是非常困难的。超声波在奥氏体焊缝中会沿金属结晶方向发生偏转,并在焊缝边界上发生散射。过去十年来,人们开发了多种模拟各向异性材料中声波传播的仿真工具。本文则以常规超声波检测方法为基础,将声线跟踪法和弹性动力学有限积分技术(EFIT)相结合,应用于含晶间应力腐蚀裂纹的厚壁奥氏体焊缝中,其结果显示声线跟踪法和弹性动力学有限积分技术(EFIT)结合应用,有助于超声波检测参数的选取。 | Han T Y Khler B Schmitz V Zimmer A Langenberg K J | 2009 | 无损检测2009，31，11： | 3 |
| 3 | Mechanism of Surface-Enhanced Raman Scattering and Its Application to Highly Sensitive Protein Detection显示文摘Surface-enhanced resonance Raman scattering(SERRS)has recently attracted great interest in analytical science due toenormous enhancement factors that have decreased the detec-tionli mits of a wide variety of molecules to the single moleculelevel.The SERRS-electromagnetic(EM)model describessingle-molecule SERRS | Ozaki Y Itoh T Yoshida K Kitahama Y Han X X Zhao B | 2009 | 光谱学与光谱分析2009，29，2： | 2 |
| 4 | Analysis of exonic splicing enhancers in the mouse ganadotropin-releasing hormone (GnRH) gene 显示文摘 | Han J Seong J Y Kim K | 2001 | Molecular and Cellular Endocrinology2001，173，12： | 1 |
| 5 | Fabrication of Aluminum/Copper Clad Composite Using Hot Hydrostatic Extrusion Process and Its Material Characteristics显示文摘 | Rhee K Y Han W Y Park H J | 2004 | Materials Science and Engineering2004，384，12： | 1 |
| 6 | Antioxidative or prooxidative effect of 4-hydroxyquinoline derivatives on free-radical-initiated hemolysis of erythrocytes is due to its distributive status 显示文摘 | Liu Z Q Han K Lin Y J | 2002 | Biochimica et Biophysica Acta2002，157，： | 1 |
| 7 | Microstruetural characterization of Al2O3-Ni composites prepared by electroless deposition 显示文摘 | OH I H LEE J Y HAN J K | 2005 | Surf Coat Technol2005，192，： | 1 |
| 8 | Improved enzymatic hydrolysis yield of rice straw using electron beam irradiation pretreatment显示文摘 | Bak J S Ko J K Han Y H | 2009 | Bioresource Technology2009，100，： | 1 |
| 9 | Sorption of the herbicide mefenacet in soils显示文摘 | Lu Y Han S K Zhang C D | 2001 | Environmental Contamination and Toxicology2001，66，1： | 1 |
| 10 | Cholangioearcinoma:pictorial essay of CT and cholangiographic findings显示文摘 | Han J K Choi B I Kim A Y | 2002 | Radiographics2002，22，1： | 1 |
| 11 | Uneven wall temperature effect on local heat transfer in a rotating two-pass square channel with smooth wall显示文摘 | Han J C Zhang Y M Kalkuehler K | 1993 | ASME Journal of Heat Transfer1993，115，： | 1 |
| 12 | Association between hepatitis B virus infection and HLA-DR type in Korea显示文摘 | Ahn S H Han K H Park J Y | 2000 | J Hepat2000，31，6： | 1 |
| 13 | Microstructure and hydrogenation behavior of ball-milled and melt-spun Mg-10Ni-2Mm alloys 显示文摘 | WU Y HAN W ZttOU S X LOTOTSKY M V SOLBERG J K YARTYS V A | 2008 | J Alloys Compd2008，466，12： | 1 |
| 14 | Effects of nitrogen fertiliser and wheat straw application on CH4 and N20 emissions from a paddy rice field显示文摘 | Ma J Li XL Xu H Han Y Cai ZC Yagi K | 2007 | Australian Journal of Soil Research2007，45，： | 1 |
| 15 | Castleman diseaseof the abdomen: imaging spectrum and clinicopatholog-ic correlations 显示文摘 | Kim T J Han J K Kim Y H | 2001 | J Comput Assist Tomogr2001，25，： | 1 |
| 16 | Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos显示文摘 | Kang Y K Park J S Koo D B Choi Y H Kim S U Lee K K Han Y M | 2002 | The EMBO journal2002，21，5： | 1 |
| 17 | Piperine inhibition of 1-methyl4- phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells显示文摘 | Lee C S Han E S Kim Y K | 2006 | Eur J Pharmaco12006，537，13： | 1 |
| 18 | Wear Behaviour of Aluminium Matrix Composite Materials 显示文摘 | Lee C S Kim Y H Han K S | 1990 | Journal of Materials Science1990，，3： | 1 |
| 19 | Synthesis and degradation of end-group-functionalized polylactide显示文摘 | Lee S H Kim S H Han Y K | | 0，，： | 1 |
| 20 | A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis显示文摘 | Ren D Liu Y Yang K Y Han L Mao G Glazebrook J Zhang S | | 0，，： | 1 |
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