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| 1 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 2 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 3 | Macrodiversity power control in hierarchical CDMA cellular systems显示文摘 | KIM J Y GORDON L S IAN F A | 2001 | IEEE Journal on Selected Areas in Commun2001，19，2： | 2 |
| 4 | 由磁共振成像评估的主动脉弓脉搏波传导速度是心血管事件的预测因子:多种族动脉粥样硬化研究显示文摘通过磁共振成像评估的主动脉弓脉搏波传导速度(pulse wave velocity,PWV)对心血管病事件的预测价值尚未完全确定。为了评估多种族动脉粥样硬化研究(multi-ethnic study of atherosclerosis,MESA)受试者中主动脉弓PWV与心血管病的关系,Ohyama等纳入3527例MESA受试者[基线时平均年龄为(62±10)岁,47%为男性], | 刘莉 叶鹏 Ohyama Y Ambale-Venkatesh B Noda C Kim JY Tanami Y Teixido-Tura G Chugh AR Redheuil A Liu CY Wu CO Hundley WG Bluemke DA Guallar E Lima JAC | 2017 | 中华高血压杂志2017，25，8： | 2 |
| 5 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 6 | Enzyme-linked Immunosorbent Assays for the Insecticide Fenitrothion Influence of Hapten Conformation and Sample Matrix on Assay Performance 显示文摘 | KIM Y J KIM Y A LEE Y T | 2007 | Analytica Chimica Acta2007，591，： | 1 |
| 7 | Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells显示文摘 | Kim Y A Choi B T Lee Y T | 2004 | Oncol Rep2004，11，2： | 1 |
| 8 | Efficacy and safety of sorafenib in patients in the Asia Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised,double-blind, placebo controlled trial显示文摘 | Cheng A L Kang Y K Chen Z Tsao C J Qin S Kim J S | 2009 | Lancet Oncol2009，10，： | 1 |
| 9 | A first principles investigation of new cathode materials for advanced lithium batteries显示文摘 | Jeon Y A Kim S K Kim Y S | 2006 | Journal of Electroceramics2006，17，： | 1 |
| 10 | Biochemical enhance-ment of transdermal delivery with magainin peptide:modifica-tion of electrostatic interactions by changing pH显示文摘 | KIM Y C LATE S BANQA A K | 2008 | Int JPharm2008，362，12： | 1 |
| 11 | Cholangioearcinoma:pictorial essay of CT and cholangiographic findings显示文摘 | Han J K Choi B I Kim A Y | 2002 | Radiographics2002，22，1： | 1 |
| 12 | Spatial distribution of nerve sprouting after myocardial infarction in mice显示文摘 | Oh Y S Jong A Y Kim D T | 2006 | Heart Rhythm2006，3，6： | 1 |
| 13 | Small (< or =2cm) hepatic lesions in colorectal cancer patients:detection and characterization on mangafodipir trisodium-enhanced MRI显示文摘 | Kim K W Kim A Y Kim T K | 2004 | Am J Roentgenol2004，182，5： | 1 |
| 14 | Modified Hodge and EDTA-disk synergy tests to screen metallo-beta-lactamase-producing strains of Pseudomonas and Acinetobacter species显示文摘 | Lee K Y·Chong H·B·Shin Y·A·Kim D·Yong and J·H·Yum | 2001 | Clin Microbiol Infect2001，7，： | 1 |
| 15 | Identification of many microRNAs that copurify with polyribosomes in mammalian neurons显示文摘 | KIM J KRICHEVSKY A GRAD Y | 2004 | Proc Natl Acad Sci USA2004，101，： | 1 |
| 16 | Suppression of NF-kappaB activity by NDRG2 expression attenuates the invasive potential of highly malignant tumor cells显示文摘 | Kim A Kim MJ Yang Y | 2009 | Carcinogenesis2009，30，6： | 1 |
| 17 | Enhancement of receptor-operated cation current and TRPC6 expression in arterial smooth muscle ceils of deoxycorticosterone acetate-salt hypertensive rats显示文摘 | Bae Y M Kim A Lee Y J | 2007 | J Hypertens2007，25，4： | 1 |
| 18 | Marketing your community:image analysis of Norfolk 显示文摘 | Chon K Weaver P A Kim C Y | 1991 | The Cornell H R A Quarterly1991，31，4： | 1 |
| 19 | Detection of approximately 10( 3 ) copies of DNA by an electrochemical enzyme- amplified sandwich assay with ambient O (2)as the substrate显示文摘 | Zhang Y Pothukuchy A Shin W Kim Y and Heller A | 2004 | Analytical Chemistry2004，76，： | 1 |
| 20 | microRNA directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems 显示文摘 | Kim J Jung J H Reyes J L kim Y S Kim S Y Chung K S Kiln J A Lee M Lee Y Kim V N | 2005 | The Plant Journal2005，42，： | 1 |
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