维普中文期刊产品整合服务
3篇 您的检索式:作者名="K.Albrecht"
    题名 作者 年代 出处 被引量
1Interleukin 28B polymorphisms are the only common genetic variants associated with low‐density lipoprotein cholesterol (LDL‐C) in genotype‐1 chronic hepatitis C and determine the association between LDL‐C and treatment response显示文摘P. J.Clark A. J.Thompson M.Zhu D. M.Vock Q.Zhu D.Ge K.Patel S. A.Harrison T. J.Urban S.Naggie J.Fellay H. L.Tillmann K.Shianna S.Noviello L. D.Pedicone R.Esteban P.Kwo M. S.Sulkowski N.Afdhal J. K.Albrecht D. B.Goldstein J. G.McHutchison A. J.Muir 2012Journal of Viral Hepatitis2012,,5:1
2Interleukin 28B polymorphisms are the only common genetic variants associated with low‐density lipoprotein cholesterol (LDL‐C) in genotype‐1 chronic hepatitis C and determine the association between LDL‐C and treatment response显示文摘P. J.Clark A. J.Thompson M.Zhu D. M.Vock Q.Zhu D.Ge K.Patel S. A.Harrison T. J.Urban S.Naggie J.Fellay H. L.Tillmann K.Shianna S.Noviello L. D.Pedicone R.Esteban P.Kwo M. S.Sulkowski N.Afdhal J. K.Albrecht D. B.Goldstein J. G.McHutchison A. J.Muir 2012Journal of Viral Hepatitis2012,,5:1
3Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment显示文摘Intermittent injections of parathyroid hormone(iPTH) are applied clinically to stimulate bone formation by osteoblasts, although continuous elevation of parathyroid hormone(PTH) primarily results in increased bone resorption. Here, we identified Calca,encoding the sepsis biomarker procalcitonin(ProCT), as a novel target gene of PTH in murine osteoblasts that inhibits osteoclast formation. During iPTH treatment, mice lacking ProCT develop increased bone resorption with excessive osteoclast formation in both the long bones and axial skeleton. Mechanistically, ProCT inhibits the expression of key mediators involved in the recruitment of macrophages, representing osteoclast precursors. Accordingly, ProCT arrests macrophage migration and causes inhibition of early but not late osteoclastogenesis. In conclusion, our results reveal a potential role of osteoblast-derived ProCT in the bone microenvironment that is required to limit bone resorption during iPTH.Anke Baranowsky Denise Jahn Shan Jiang Timur Yorgan Peter Ludewig Jessika Appelt Kai K.Albrecht Ellen Otto Paul Knapstein Antonia Donat Jack Winneberger Lana Rosenthal Paul Köhli Cordula Erdmann Melanie Fuchs Karl-Heinz Frosch Serafeim Tsitsilonis Michael Amling Thorsten Schinke Johannes Keller 2022Bone Research2022,10,1:0
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费