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| 1 | Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration显示文摘Resolving regional carbon budgets is critical for informing land-based mitigation policy.For nine regions covering nearly the whole globe,we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing.The net land–atmospheric carbon exchange(NEE)was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade,and riverine-carbon export to the ocean.Summing up NEE from all regions,we obtained a global‘bottom-up'NEE for net land anthropogenic CO_(2)uptake of–2.2±0.6 Pg C yr^(-1)consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009.This estimate is so far the most comprehensive global bottom-up carbon budget accounting,which set up an important milestone for global carbon-cycle studies.By decomposing NEE into component fluxes,we found that global soil heterotrophic respiration amounts to a source of CO_(2)of 39 Pg C yr^(-1)with an interquartile of 33–46 Pg C yr^(-1)—a much smaller portion of net primary productivity than previously reported. | Philippe Ciais Yitong Yao Thomas Gasser Alessandro Baccini Yilong Wang Ronny Lauerwald Shushi Peng Ana Bastos Wei Li Peter A.Raymond Josep G.Canadell Glen P.Peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann Goulven Laruelle Alexandra G.Konings Anthony W.King Yi Liu Sebastiaan Luyssaert Fabienne Maignan Prabir K.Patra Anna Peregon Pierre Regnier Julia Pongratz Benjamin Poulter Anatoly Shvidenko Riccardo Valentini Rong Wang Grégoire Broquet Yi Yin Jakob Zscheischler Bertrand Guenet Daniel SGoll Ashley-P.Ballantyne Hui Yang Chunjing Qiu Dan Zhu | 2021 | National Science Review2021，8，2： | 3 |
| 2 | B cell development is critically dependent on NFATc1 activity显示文摘B cell development in bone marrow is a precisely regulated complex process.Through successive stages of differentiation,which are regulated by a multitude of signaling pathways and an array of lineage-specific transcription factors,the common lymphoid progenitors ultimately give rise to mature B cells.Similar to early thymocyte development in the thymus,early B cell development in bone marrow is critically dependent on IL-7 signaling.During this IL-7-dependent stage of differentiation,several transcription factors,such as E2A,EBF1,and Pax5,among others,play indispensable roles in B lineage specification and maintenance.Although recent studies have implicated several other transcription factors in B cell development,the role of NFATc1 in early B cell developmental stages is not known.Here,using multiple gene-manipulated mouse models and applying various experimental methods,we show that NFATc1 activity is vital for early B cell differentiation.Lack of NFATc1 activity in pro-B cells suppresses EBF1 expression,impairs immunoglobulin gene rearrangement,and thereby preBCR formation,resulting in defective B cell development.Overall,deficiency in NFATc1 activity arrested the pro-B cell transition to the pre-B cell stage,leading to severe B cell lymphopenia.Our findings suggest that,along with other transcription factors,NFATc1 is a critical component of the signaling mechanism that facilitates early B cell differentiation. | Sabrina Giampaolo Gabriela Wojcik Stefan Klein-Hessling Edgar Serfling Amiya K.Patra | 2019 | Cellular & Molecular Immunology2019，16，5： | 3 |
| 3 | Inner-View of Nanomaterial Incited Protein Conformational Changes: Insights into Desig显示文摘Nanoparticle bioreactivity critically depends upon interaction between proteins and nanomaterials(NM).Te formation of the“protein corona”(PC)is the efect of such nanoprotein interactions.PC has a wide usage in pharmaceuticals,drug delivery,medicine,and industrial biotechnology.Terefore,a detailed in-vitro,in-vivo,and in-silico understanding of nanoprotein interaction is fundamental and has a genuine contemporary appeal.NM surfaces can modify the protein conformation during interaction,or NMs themselves can lead to self-aggregations.Both phenomena can change the whole downstream bioreactivity of the concerned nanosystem.Te main aim of this review is to understand the mechanistic view of NM-protein interaction and recapitulate the underlying physical chemistry behind the formation of such complicated macromolecular assemblies,to provide a critical overview of the diferent models describing NM induced structural and functional modifcation of proteins.Te review also attempts to point out the current limitation in understanding the feld and highlights the future scopes,involving a plausible proposition of how artifcial intelligence could be aided to explore such systems for the prediction and directed design of the desired NM-protein interactions. | Arka Mukhopadhyay Sankar Basu Santiswarup Singha Hirak K.Patra | 2018 | Research2018，，1： | 2 |
| 4 | Molecular characterization and expression patterns of Nanog gene validating its involvement in the embryonic development and maintenance of spermatogonial stem cells of farmed carp,Labeo rohita显示文摘Background: The homeobox containing transcription factor Nanog plays crucial roles in embryonic development/proliferation and/or maintenance of spermatogonial stem cells(SSCs) via interacting with transcription factors such as Oct4 and Sox2 in mammals. However, knowledge of its exact mechanistic pathways remains unexploited. Very little is known about teleost Nanog. Information on the Nanog gene of farmed rohu carp(Labeo rohita) is lacking. We cloned and characterized the Nanog gene of rohu carp to understand the expression pattern in early developmental stages and also deduced the genomic organization including promoter elements.Results: Rohu Nanog(LrNanog) cDNA comprised an open reading frame of 1,161 nucleotides bearing a structural homeodomain; whereas, the genomic structure contained four exons and three introns suggesting that it is homologous to mammalian counterparts. Phylogenetical y, it was closely related to freshwater counterparts. Protein sequence(386 AA of42.65 kDa) comparison revealed its low similarity with other vertebrate counterparts except that of the conserved homeodomain. Tissue distribution analysis revealed the existence of LrNanog transcripts only in adult gonads. The heightened abundances in the ovary and proliferating spermatogonia suggested its participations in maternal inheritance and male germ cell development. The potentiating abundances from fertilized egg onwards peaking at blastula stage vis-à-vis decreasing levels from gastrula stage onwards demonstrated its role in embryonic stem cell development. We also provided evidence of its presence in SSCs by western blotting analysis. Further, the promoter region was characterized, predicting a basal core promoter and other consensus elements.Conclusion: The molecular characterization of LrNanog and its documented expression profiling at transcript and protein levels are indicative of its functional linkage with embryonic/spermatogonial stem cell maintenance. This is the first report of LrNanog genomic organization including its promoter sequence information with predicted regulatory elements of a large-bodied carp species. This will be useful for elucidating its mechanism expression in future. Nanog could be used as a potential biomarker for proliferating carp SSCs. | Swagat K.Patra Chakrpani Vemulawada Meenati M.Soren Jitendra K.Sundaray Manoj K.PANDa Hirak K.Barman | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 1 |
| 5 | New aspects of HSC mobilization for better therapeutic outcomes显示文摘Hematopoietic stem cell(HSC)mobilization is a core issue in stem cell therapy in multiple clinical settings,such as postcancer treatment with radiotherapy and chemotherapy and treatments for primary immune deficiency and various other blood disorders.Two critical factors that determine the efficacy and usefulness of HSC therapy are the‘quality’in terms of engraftment efficiency,proliferative capacity,survival rate,etc. | Amiya K.Patra | 2021 | Cellular & Molecular Immunology2021，18，12： | 0 |
| 6 | 黄麻织物的生物酶精练:迈向生物工艺的一步显示文摘黄麻织物的化学加工过程中,精练是重要的一步。为了使精练工艺更加环境友好,介入生物处理的技术已被广泛研究。采用纤维素酶、木聚糖酶和非离子表面活性剂进行生物酶精练黄麻织物,其精练效果可与传统的高温化学精练相媲美。由于生物酶精练不使用有毒的化学药品,且可在低温下进行,因此属生态友好节能之工艺。 | N.C.Pan S.N.Chattopadhyay A.K.Roy K.Patra A.Khan 李改莉 王文义 | 2010 | 国际纺织导报2010，38，7： | 0 |
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