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| 1 | Transradial versus transfemoral access for anterior circulation mechanical thrombectomy: analysis of 375 consecutive cases显示文摘Objective To compare transradial artery access(TRA)to the gold standard of transfemoral artery access(TFA)in mechanical thrombectomy(MT)for stroke caused by anterior circulation large vessel occlusion.Methods The clinical outcomes,procedural speed,angiographic efficacy and safety of both techniques were analysed in 375 consecutive cases over an 18-month period in a high volume statewide neurointerventional service.Results There was no significant difference in patient characteristics,stroke parameters,imaging techniques or intracranial techniques.The median time elapsed between CT scanning and reperfusion was 96.5 min(IQR 68-123)in the TFA group and 95 min(IQR 68-123)in the TRA group(p=0.456).Of 336 patients who were independent at presentation 58%(124/214)of the TFA group and 67%(82/122)of the TRA group had a modified Rankin score of 0-2 at 90-day follow-up(p=0.093).Cross-over from radial to femoral was 4.6%(4/130)compared with 1.6%cross-over from femoral to radial(4/245),but did not meet the predetermined level of statistical significance(OR2.92,95% CI 0.81 to 10.52,p=0.088) and did not impact median procedural speed.Adequate angiographic reperfusion,first pass reperfusion,embolisation to new territory and symptomatic intracranial haemorrhage were similar in both groups.There was a significant difference in major access site complications requiring an additional procedure.None of the TRA cases had a major access site complication but 6.5%(16/245)of the TFA cases did(p=0.003).Conclusion This study suggests that using TRA for anterior circulation MT is fast,efficacious,safe and not inferior to the gold standard of TFA. | Timothy John Phillips Matthew Thomas Crockett Gregory D Selkirk Ruchi Kabra Albert Ho Yuen Chiu Tejinder Singh Constantine Phatouros William McAuliffe | 2021 | Stroke & Vascular Neurology2021，6，2： | 7 |
| 2 | CT patterns of nodal disease in pediatric chest tuberculosis显示文摘AIM:To highlight various patterns of nodal involvement and post treatment changes in pediatric chest tuberculosis based on contrast enhanced computed tomography(CECT) scans of chest.METHODS:This was a retrospective study consisting of 91 patients aged less than 17 years,who attended Paediatrics OPD of All India Institute of Medical Sciences with clinically diagnosed tuberculosis or with chest radiographs suggestive of chest tuberculosis.These patients had an initial chest radiograph as well as CECT of the chest and follow up imaging after 6 mo,and in some cases 9 mo,of completion of anti-tubercular treatment(ATT).CECT of these patients was reviewed for the location and extent of nodal involvement along with determination of site,size,enhancement pattern and calcification.RESULTS:Enlargement of mediastinal or hilar lymph nodes was found in 88/91 patients(96.7%),with the most common locations being paratracheal(84.1%),and subcarinal(76.1%).The most common pattern of enhancement was found to be inhomogenous.The nodes were conglomerate in 56.8% and discrete in 43.2%.In addition,perinodal fat was obscured in 84.1% of patients.In the post-treatment scan,there was 87.4% reduction in the size of the nodes.All nodes post-treatment were discrete and homogenous with perinodal fat present.Calcification was found both pre-and post-treatment,but there was an increase in incidence after treatment(41.7%).There was hence a reduction in size,change in enhancement pattern,and appearance of perinodal fat with treatment.CONCLUSION:Tubercular nodes have varied appearance and enhancement pattern.Conglomeration and obscuration of perinodal fat suggest activity.In residual nodes decision to continue ATT requires clinical correlation. | Amar Mukund Rashmi Khurana Ashu S Bhalla Arun K Gupta Sushil K Kabra | 2011 | World Journal of Radiology2011，3，1： | 5 |
| 3 | Pediatric vs adult pulmonary tuberculosis:A retrospective computed tomography study显示文摘AIM: To compare the manifestations of chest tuberculosis(TB) in pediatric and adult patients based on contrast enhanced computed tomography of chest.METHODS: This was a retrospective study consisting of 152 patients of chest TB including 48 children and 104 adults who had undergone contrast enhanced computed tomography of chest prior to treatment. The patterns and severity of parenchymal, mediastinal and pleural manifestations were analyzed and compared among different age groups.RESULTS: Parenchymal changes observed include consolidation, air space nodules, miliary TB, cavitation, bronchiectasis and fibrosis and these were noted in 60% of children, 71% of adolescents and 76.9% of adults. These changes were more common in right upper lobe in all age groups. There was no significant difference in the frequency of these changes(except nodules) in different age groups. Centrilobular nodules were seen less commonly in children less than 10 years(P = 0.028). Pleural effusion was noted in 28(18.42%) patients and pericardial effusion in 8(5.3%) patients. No significant difference in the serosal involvement is seen among children and adults. Mediastinal adenopathy was seen 70% of children, 76.3% adolescents and 76.9% of adults and paratracheal nodes were seen most frequently. Nodes had similar features(except matting) among all age groups. Matting of nodes was seen more commonly in children(P = 0.014). CONCLUSION: Pediatric chest tuberculosis can have severe parenchymal lesions and nodal involvement similar to adults. The destructive lung changes observed in children needs immediate attention in view of the longer life span they have and hence in formulating optimal treatment strategies. | Prasad Thotton Veedu Ashu Seith Bhalla Sreenivas Vishnubhatla Sushil Kumar Kabra Arundeep Arora Divya Singh Arun Kumar Gupta | 2013 | World Journal of Clinical Pediatrics2013，2，4： | 2 |
| 4 | SirT1 is an inhibitor of proliferation and tumor formation in colon cancer 显示文摘 | Kabra N Li Z Chen L | 2009 | J Biol Chem2009，284，18： | 1 |
| 5 | Vasopressin infusion in children with catecholamine-resistant septic shock 显示文摘 | Vasuvedan A Lodha R Kabra S | 2005 | Acta Paediatr2005，94，： | 1 |
| 6 | Upper respiratory tract infections 显示文摘 | Jain N Lodha R Kabra SK | 2001 | Indian JPed2001，68，12： | 1 |
| 7 | In vivo overexpression of Dad1, the defender against apoptotic death - 1, enhances T cell proliferation but does not protect against apoptosis显示文摘 | Kabra NH Hsieh SN | 1999 | J Immunol1999，163，4： | 1 |
| 8 | Treatment of Hazardous Organic and Inorganic Compounds through Aqueous-Phase Photocatalysis:A Review显示文摘 | KABRA K CHAUDHARY R SAWHNEY R L | 2004 | Industrial and Engineering Chemistry Research2004，43，24： | 1 |
| 9 | Risk factors for treatment outcome in fungal keratitis显示文摘 | Lalitha P Prajna N V Kabra A | 2006 | Ophthalmology2006，113，4： | 1 |
| 10 | Doxofylline:The next generation methylxanthine显示文摘 | Sankar J Lodha R Kabra SK | 2008 | Indian J Pediatr2008，75，3： | 1 |
| 11 | Cosegregation of the rennin allele of the spontaneously hypertensive rat with an increase in blood pressure显示文摘 | KURTZ T W SIMONET L KABRA P M | 1990 | J Clin Invest1990，85，4： | 1 |
| 12 | Mental retardation 显示文摘 | Kabra M Gulati S | 2003 | Indian J Pediatr2003，70，2： | 1 |
| 13 | Nedd4-2 induces endocytosis and degradation of proteolytically cleaved epithe- lial Na + channels显示文摘 | KABRA R KNIGHT K K ZHOU R | 2008 | Journal of Biological Chemistry2008，283，10： | 1 |
| 14 | Recent advances in management of bronchiolitis显示文摘 | Verma N Lodha R Kabra SK | 2013 | Indian Pediatr2013，50，10： | 1 |
| 15 | Cloning,ex-pression,and immunological characterization of theP30protein of Mycoplasma pneumoniae显示文摘 | Varshney A K Chaudhry R Kabra S K | 2008 | Clin Vac-cine Immunol2008，，2： | 1 |
| 16 | Prevalence of the triple X syndrome in phenotypically normal women with premature ovarian failure and its associat ion with autoimmune thyroid disorders显示文摘 | Goswami R Goswami D Kabra M | 2003 | Fertil Steril2003，80，4： | 1 |
| 17 | Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reversed-phase liquid chromatography:improved separation systems for polyamines in cerebrospinal fluid,urine and tissue显示文摘 | Kabra P M Lee H K Lubich W P Marton L J | 1986 | J Chromatogr1986，380，： | 1 |
| 18 | Doxofylline: the next generation methylxanthine显示文摘 | Sankar J Lodha R Kabra SK | 2008 | Indian J Pediatr2008，75，3： | 1 |
| 19 | Idiopathic pulmonary hemosiderosis: clinical profile and follow up of 26 children 显示文摘 | Kabra SK Bhargava S Lodha R | 2007 | Indian Pediatr2007，44，： | 1 |
| 20 | Doxofylline:the next generation methylxanthine显示文摘 | Sanker J Lodha R Kabra SK | 2008 | Indian J Pediatr2008，75，3： | 1 |
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