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| 1 | Emerging role of protein kinase C in energy homeostasis: A brief overview显示文摘Protein kinase C-β(PKCβ), a member of the lipidactivated serine/threonine PKC family, has been implicated in a wide range of important cellular processes. Very recently, the novel role of PKCβ in the regulation of triglyceride homeostasis via regulating mitochondrial function has been explored. In this review, I aim to provide an overview of PKCβ regarding regulation by lipids and recently gained knowledge on its role in energy homeostasis. Alterations in adipose PKCβ expression have been shown to be crucial for diet-induced obesity and related metabolic abnormalities. High-fat diet is shown to induce PKCβ expression in white adipose tissue in an isoform- and tissue-specific manner. Genetically manipulated mice devoid of PKCβ are lean with increased oxygen consumption and are resistant to high-fat diet-induced obesity and hepatic steatosis with improved insulin sensitivity. Available data support the model in which PKCβ functions as a 'diet-sensitive' metabolic sensor whose induction in adipose tissue by high-fat diet is among the initiating event disrupting mitochondrial homeostasis via intersecting with p66Shc signaling to amplify adipose dysfunction and have systemic consequences. Alterations in PKCβ expression and/orfunction may have important implications in health and disease and warrants a detailed investigation into the downstream target genes and the underlying mechanisms involved. Development of drugs that target the PKCβ pathway and identification of miRs specifically controlling PKCβ expression may lead to novel therapeutic options for treating age-related metabolic disease including fatty liver, obesity and type 2 diabetes. | Kamal D Mehta | 2014 | World Journal of Diabetes2014，5，3： | 6 |
| 2 | 南蛇藤提取物对Lewis大鼠佐剂性关节炎(AA)预防及治疗作用显示文摘目的:观察南蛇藤提取物对Mtb诱发的Lewis大鼠佐剂型关节炎的影响。方法:以Mtb(Heat-killed mycobaeterium tubreuolsis H37Ra)免疫Lewis大鼠(1mg/只),诱发佐剂性关节炎模型,免疫后8天,出现临床类风湿关节炎症状。大鼠分成预防组及治疗组,分别灌胃南蛇藤(1.5~3g/kg)、生理盐水及甲氨碟呤(0.5mg/kg)。用积分法定期评定四肢炎症程度。实验结束后,大鼠关节做病理检测。结果:实验结果表明,预防组与模型对照组比较,南蛇藤提取物显著降低关节炎模型大鼠的临床积分,抑制关节炎症的发生(P〈0.05,P〈0.01)。治疗组中南蛇藤提取物组与甲氨碟呤组比较无显著性差异(P〉0.05)。病理结果显示南蛇藤提取物可减轻Lewis大鼠关节的损伤破坏程度。结论:南蛇藤提取物对AA模型大鼠关节炎症及病情进展有显著的抑制作用。 | 佟丽 Kamal D Moudgil 陈育尧 肖长虹 | 2008 | 中国免疫学杂志2008，24，5： | 5 |
| 3 | Genome-wide analysis of histone modifications by ChiP-on-chip显示文摘 | Huebert D J Kamal M O'Donovan A | 2006 | Methods2006，40，4： | 1 |
| 4 | mucosal T cells regulate paneth and intermediate cell numbers in the small intestine of T spiralis infected mice 显示文摘 | Kamal M Wakelin D Ouellete AJ | 2001 | Clin Exp Immunol2001，126，1： | 1 |
| 5 | A multilevel automatic thresholding method based on a genetic algorithm for a fast image segmentation 显示文摘 | Kamal H Moussa D Patrick S | 2008 | Comp Vision Image Un- derstand2008，109，2： | 1 |
| 6 | A data driven failure prognostics method based on mix-ture of gaussians hidden markov models显示文摘 | Tobon-Mejia D A Kamal M Noureddine Z | 2012 | IEEE Transactions on Reliability2012，61，2： | 1 |
| 7 | Fast multilevel thresholding for image segmentation through a multiphase level set method显示文摘 | Ahmed D Kamal H and Moussa D | 2013 | Signal Processing2013，93，7： | 1 |
| 8 | Biological variability of sperm DNA denaturation in infertile men显示文摘 | Zini A Kamal K Phan D et a l | 2001 | Urology2001，58，2： | 1 |
| 9 | Reduced intravascular catheter related infection by routine use of antibiotic bonded catheter in a surgical intensive care unit显示文摘 | Kamal GD Divishek D | 1998 | Diagn Microbiol Infect dis1998，30，3： | 1 |
| 10 | Biologic variability of sperm DNA denaturation in infertile men显示文摘 | Zini A Kamal K Phang D | 2001 | Urology2001，58，2： | 1 |
| 11 | Macroscopic and microscopic findings in avascular necrosis of the femoral head 显示文摘 | Kamal D Alexandru DO Kamal CK | 2012 | Rom J Morphol EmbrY012012，53，3： | 1 |
| 12 | Five new anamorphic powdery mildews from India 显示文摘 | Ahmad Nasim Sarbhoy A K Kamal Agarwal D K | 2005 | Indian Phytopathology2005，58，1： | 1 |
| 13 | Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in pa- tients with RA显示文摘 | Metawi SA Abbas D Kamal MM | 2011 | Clin Rheumato12011，30，9： | 1 |
| 14 | Reduced intravascular catheter-related infection by routine use of antibiotic-bonded catheters in a surgical intensive care unit显示文摘 | Kamal G D Divishek D Kumar G C | 1998 | Diagn Microbiol Infect Dis1998，30，3： | 1 |
| 15 | Light transmission and haze of polyethylene blown thin films显示文摘 | Wang L Kamal M R Rey A D | 2001 | Polym Eng Sci2001，41，2： | 1 |
| 16 | Kinetics of glycolysis of poly(ethylene terephthalate) melts 显示文摘 | Campanelli J R Kamal M R Cooper D G | 1994 | J ApplPolymSci1994，54，11： | 1 |
| 17 | Mutation analysis of the GJB2 ( connexin26 ) gene in Egypt显示文摘 | Snoeckx R L Hassan D M Kamal N M | 2005 | Hum Mutat2005，26，1： | 1 |
| 18 | Reduced intravascular catheter related infection by rotine use of antibiotic bon-ded catheters in a surgical intensive care unit显示文摘 | KAMAL G D DIVISHEK D | 1998 | Diagn Microbiol Infect Dis1998，30，3： | 1 |
| 19 | The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reac- tions in a murine model of peanut allergy 显示文摘 | Kamal D S Jacob D K Zhong M Z | 2005 | J Allergy Clin Im- munol2005，115，： | 1 |
| 20 | A multilevelautomatic thresholding method based on a genetic algo-rithm for a fast image segmentation显示文摘 | KAMAL H MOUSSA D PATRICK S | 2008 | Computer Vi-sion and Image Understanding2008，109，2： | 1 |
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