|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | In vitro generation of islets in long term cultures of pluripotent stem cells from adult mouse pancreas显示文摘 | Tchernev V Kao K J | 1997 | Horm Metab Res1997，29，6： | 1 |
| 3 | Interfacial reactions and compound forma-tion of Sn-Ag-Cu Solders by mechanical alloying on electroless Ni-P/Cu under bump metallization显示文摘 | KAO S T DUH J G | 2005 | Journal of Electronic Materi-als2005，34，8： | 1 |
| 4 | Transient dynamics of a tire roiling over small obstacles a finite element approach with PAMSHOCK显示文摘 | Kamoulakos A Kao B G | 1998 | Tire Science and Technology1998，26，2： | 1 |
| 5 | The dynamics of an infectious disease in a population with birth pulse显示文摘 | ROBERTS M G KAO R R | 1998 | Math Biosci1998，149，1： | 1 |
| 6 | Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase显示文摘 | Kao CM Luo G Katz L | 1995 | Journal of the American Chemical Society1995，117，35： | 1 |
| 7 | Load-Carrying Capacities and Failure Modes of Scaffold-Shoring Systems, Part Ⅱ: An Analytical Model and Its Closed-Form Solution 显示文摘 | Huang Y L Kao Y G Rosowsky D V | 2000 | Structural Engineering and Mechanics2000，10，1： | 1 |
| 8 | International Mutual Fund selectivity and Market Timing during up and down Market Conditions显示文摘 | Kao G W L T W Cheng K C Chart | 1998 | The Financial Review1998，33，： | 1 |
| 9 | Apoptosis down-regulates inflammation under the advancing epithelial wound edge: Delayed patterns in diabetes and improvement with topical growth factors显示文摘 | BROWN D L KAO W W GREENHALGH D G | 1997 | Surgery1997，121，： | 1 |
| 10 | Plasmainduced grafted polymerization of acrylic acid and subsequent grafting of collagen onto polymer film as biomaterials显示文摘 | Lee S D Hsiue G H AQ13 Chang P C T Kao C | 1996 | Biomaterials1996，17，： | 1 |
| 11 | On exchange rate changes and stock price reactions显示文摘 | CHRISTOPHER K M KAO G | 1990 | Journal of Business Finance& Accounting1990，17，3： | 1 |
| 12 | The effect of carbon coating thickness on the capacity of LiFePO4/C composite cathodes显示文摘 | Cho Y D Feya G T K Kao H M | 2009 | Journal of Power Sources2009，189，： | 1 |
| 13 | Quantification of O-acetyl, iV-acetyl andphosphate groups and determination of the extent of O-acetylation inbacterial vaccine polysaccharides by high-performance anion-exchangechromatography with conductivity detection (HPAEC-CD)显示文摘 | KAO G TSAI C M | 2004 | Vaccine2004，22，3： | 1 |
| 14 | Tire transient analysis with explicit finite element program显示文摘 | Kao B G Nuthukrishnan M | 1997 | Tire Science and Technology1997，25，4： | 1 |
| 15 | Robust linearized image reconstruction for multifrequency EIT of the breast显示文摘 | BOVERMAN G KAO T J KULKAMI R | 2008 | IEEE Transactions on Medical Imaging2008，27，10： | 1 |
| 16 | Identification of the pollen determinant of S-RNase-mediated self-incompatibility显示文摘 | SIJACIC P WANG X SKIRPAN A L WANG Y DOWD P E MCCUBBIN A G HUANG S KAO T H | 2004 | Nature2004，429，6989： | 1 |
| 17 | Regional admittivity spectra with tomosynthesis images for breast cancer detection: Preliminary patient study显示文摘 | KAO T J BOVERMAN G KIM B S | 2008 | IEEE Transactions on Medical Imaging2008，27，12： | 1 |
| 18 | Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions显示文摘 | Wang C Y Kao T C Lo W H Yen G C | 2011 | J Agric Food Chem2011，59，： | 1 |
| 19 | Rabies and borna disease: a comparative pathogenetic study of two neurovirulent agent显示文摘 | Gosztonyi G Dietzschold B Kao M | 1993 | Lab Invest1993，68，： | 1 |
| 20 | Identification of self-incompatibility (S-) locus linked pollen cDNA markers in Petunia inflata显示文摘 | MCCUBBIN A G WANG X KAO T H | 2000 | Genome2000，43，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员