|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Accuracy of EUS in the evaluation of small gastric subepithelial lesions显示文摘 | Karaca C Turner BG Cizginer S | 2010 | Gastrointest Endosc2010，，： | 1 |
| 3 | Emulsifying properties of chickpea,faba bean,lentil and pea proteins produced by isoelectric precipitation and salt extraction显示文摘 | Karaca A C Low N Nickerson M | 2011 | Food Research International2011，44，9： | 1 |
| 4 | Structural changes of smooth muscie in congenital ureteropelvic junction obstruction显示文摘 | Hosgor M Karaca I Ulukus C | 2005 | J PediatrSurg2005，40，10： | 1 |
| 5 | Repair of cartilage defects with periosteal grafts显示文摘 | Ulutas K Menderes A Karaca C | 2005 | Br J Plast Surg2005，58，1： | 1 |
| 6 | Identification of a basallike subtype of breast ductal carcinoma in situ 显示文摘 | Livasy C A Perou C M Karaca G | 2007 | Hum Pathol2007，38，： | 1 |
| 7 | Phenotypic evaluation of the basalqike subtype of invasive breast carcinoma显示文摘 | Livasy C A Karaca G Nanda R | 2006 | Mod Pathol2006，19，2： | 1 |
| 8 | Clinical and laboratory eval- uation of periodically monitored Turkish children with IgG subclass deficiencies显示文摘 | Karaca NE Karadeniz C Aksu G | 2009 | Asian Pac J Allergy Immuuol2009，27，1： | 1 |
| 9 | Simple, rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology 显示文摘 | Blasco R B Karaca E Ambrogio C | 2014 | Cell Rep2014，9，4： | 1 |
| 10 | Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steato- hepatitis 显示文摘 | Witek R P Stone W C Karaca F G | 2009 | Hepatol2009，50，5： | 1 |
| 11 | Performance characteristics of apad evaporative cooling system in a broiler house in a Mediterraneanclimate显示文摘 | Dagtekin M Karaca C Yildiz Y | 2009 | Biosystems Eng2009，103，1： | 1 |
| 12 | A novel variant of avian infectious bronchitis virus resulting from recom bination among three different strains显示文摘 | Jia W Karaca K Parrish C R | 1995 | Arch Virol1995，40，2： | 1 |
| 13 | Cardioprotective effect of aprotinin on myocardial ischemia/reperfusion injury during cardiopulmonary bypass显示文摘 | Karaca P Konuralp C Enc Y | 2006 | Circulation2006，70，11： | 1 |
| 14 | Effects of soft contact lenses on conjunctival surface 显示文摘 | Cakamas SS Unlu MK Karaca C Nergiz Y Ipek S | 2003 | Eye Contact Lens2003，29，4： | 1 |
| 15 | Adolescent growth patterns of the bony and cartilaginous framework of the nose: A cephalometric study显示文摘 | Akgtiner M Barutcu A Karaca C | 1998 | Ann Plast Surg1998，41，1： | 1 |
| 16 | Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma显示文摘 | LIVASY C A KARACA G NANDA R | 2006 | Mod Pathol2006，19，2： | 1 |
| 17 | Structural changes of smooth muscle in congenital ureteropelvic junction obstruction 显示文摘 | Hosgor M Karaca I Ulukus C | 2005 | J Padiatr Surg2005，40，10： | 1 |
| 18 | A novel variant of avian infectious bronchitis virus resulting from recombination among three different strains显示文摘 | JIA W KARACA K PARRISH C R | 1995 | Arch Virol1995，140，： | 1 |
| 19 | Role of uncoupling protein UCP2 in cell-mediated immunity:how macrophnge-mediated insulitis is accelerated in a model of autoimmune diabetes显示文摘 | Emre Y Hurtaud C Karaca M | 2007 | Proc NatlAcad Sci USA2007，104，19： | 1 |
| 20 | A novel variant of avian infectious bronchitis virus resulting from recombination among three different strains 显示文摘 | Jia W Karaca K Parrish C R | 1995 | Arch Virol1995，140，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员