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| 1 | Role of diet and nutrition in inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs)are closely linked to nutrition.The latest research indicates that diet and nutrition are significantly involved in the etiopathogenesis of the disease,although their specific role throughout its clinical course still remains unclear.This study reviewed how diet and nutrition are associated with IBD development and management.Even though specific diets have been shown to bring about positive outcomes,there is currently no scientific consensus regarding an appropriate diet that would benefit all IBD patients.We suggest that individualized dietary recommendations are of the greatest importance and that diets should be planned to provide individual IBD patients with specific nutrient requirements while keeping all the clinical aspects of the patients in mind.Further research is clearly necessary to investigate nutritional factors involved in IBD development and,especially,to evaluate the applications of the diets during the course of the disease. | Marina Moreira de Castro Lívia Bitencourt Pascoal Karine Mariane Steigleder Beatriz Piatezzi Siqueira Ligiana Pires Corona Maria de Lourdes Setsuko Ayrizono Marciane Milanski Raquel Franco Leal | 2021 | World Journal of Experimental Medicine2021，11，1： | 2 |
| 2 | Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese显示文摘 | Judith Aron-Wisnewsky Caroline Minville Joan Tordjman Patrick Lévy Jean-Luc Bouillot Arnaud Basdevant Pierre Bedossa Karine Clément Jean-Louis Pépin | 2011 | Journal of Hepatology2011，，1： | 2 |
| 3 | Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry显示文摘BACKGROUND Acute pancreatitis(AP)and recurring AP are serious health care problems causing excruciating pain and potentially lethal outcomes due to sepsis.The validated caerulein-(CAE)induced mouse model of acute/recurring AP produces secondary persistent hypersensitivity and anxiety-like behavioral changes for study.AIM To determine efficacy of acetyl-L-carnitine(ALC)to reduce pain-related behaviors and brain microglial activation along the pain circuitry in CAE-pancreatitis.METHODS Pancreatitis was induced with 6 hly intraperitoneal(i.p.)injections of CAE(50μg/kg),3 d a week for 6 wk in male C57BL/6J mice.Starting in week 4,mice received either vehicle or ALC until experiment’s end.Mechanical hypersensitivity was assessed with von Frey filaments.Heat hypersensitivity was determined with the hotplate test.Anxiety-like behavior was tested in week 6 using elevated plus maze and open field tests.Microglial activation in brain was quantified histologically by immunostaining for ionized calcium-binding adaptor molecule 1(Iba1).RESULTS Mice with CAE-induced pancreatitis had significantly reduced mechanical withdrawal thresholds and heat response latencies,indicating ongoing pain.Treatment with ALC attenuated inflammation-induced hypersensitivity,but hypersensitivity due to abdominal wall injury caused by repeated intraperitoneal injections persisted.Animals with pancreatitis displayed spontaneous anxiety-like behavior in the elevated plus maze compared to controls.Treatment with ALC resulted in increased numbers of rearing activity events,but time spent in“safety”was not changed.After all the abdominal injections,pancreata were translucent if excised at experiment’s end and opaque if excised on the subsequent day,indicative of spontaneous healing.Post mortem histopathological analysis performed on pancreas sections stained with Sirius Red and Fast Green identified wide-spread fibrosis and acinar cell atrophy in sections from mice with CAE-induced pancreatitis that was not rescued by treatment with ALC.Microglial Iba1 immunostaining was significantly increased in hippocampus,thalamus(intralaminar nuclei),hypothalamus,and amygdala of mice with CAE-induced pancreatitis compared to naïve controls but unchanged in the primary somatosensory cortex compared to naïves.CONCLUSION CAE-induced pancreatitis caused increased pain-related behaviors,pancreatic fibrosis,and brain microglial changes.ALC alleviated CAE-induced mechanical and heat hypersensitivity but not abdominal wall injury-induced hypersensitivity caused by the repeated injections. | Sabrina L McIlwrath Marlene E Starr Abigail E High Hiroshi Saito Karin N Westlund | 2021 | World Journal of Gastroenterology2021，27，9： | 2 |
| 4 | Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats显示文摘AIM:To characterize an alcohol and high fat diet induced chronic pancreatitis rat model that mimics poor human dietary choices.METHODS:Experimental rats were fed a modified Lieber-De Carli alcohol(6%) and high-fat(65%) diet(AHF) for 10 wk while control animals received a regular rodent chow diet.Weekly behavioral tests determinedmechanical and heat sensitivity.In week 10 a fasting glucose tolerance test was performed,measuring blood glucose levels before and after a 2 g/kg bodyweight intraperitoneal(i.p.) injection of glucose.Post mortem histological analysis was performed by staining pancreas and liver tissue sections with hematoxylin and eosin.Pancreas sections were also stained with Sirius red and fast green to quantify collagen content.Insulinexpressing cells were identified immunohistochemically in separate sections.Tissue staining density was quantified using Image J software.After mechanical and heat sensitivity became stable(weeks 6-10) in the AHF-fed animals,three different drugs were tested for their efficacy in attenuating pancreatitis associated hypersensitivity:a Group Ⅱ metabotropic glutamate receptor specific agonist(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate(APDC,3 mg/kg,ip; Tocris,Bristol,United Kingdom),nociceptin(20,60,200 nmol/kg,ip; Tocris),and morphine sulfate(3 mg/kg,μ-opioid receptor agonist; Baxter Healthcare,Deerfield,IL,United States).RESULTS:Histological analysis of pancreas and liver determined that unlike control rats,AHF fed animals had pancreatic fibrosis,acinar and beta cell atrophy,with steatosis in both organs.Fat vacuolization was significantly increased in AHF fed rats(6.4% ± 1.1% in controls vs 23.8% ± 4.2%,P < 0.05).Rats fed the AHF diet had reduced fasting glucose tolerance in week 10 when peak blood glucose levels reached significantly higher concentrations than controls(127.4 ± 9.2 mg/d L in controls vs 161.0 ± 8.6 mg/d L,P < 0.05).This concurred with a 3.5 fold higher incidence of single and small 2-10 cell insulin-positive cell clusters(P < 0.05).Insulin expressing islet of Langerhans cells appeared hypertrophied while islet number and area measurements were not different from controls.Weekly behavioral tests determined that mechanical and heat sensitivities were significantly increased by 4 wk on AHF diet compared to controls.Hypersensitivitywas attenuated with efficacy similar to morphine with single dose treatment of either metabotropic glutamate receptor 2/3 agonist APDC,or nociceptin,the endogenous ligand for opioid-receptor-like 1 receptor.CONCLUSION:The AHF diet induces a chronic alcoholic pancreatitis in rats with measurable features resembling clinical patients with chronic pancreatitis and type 3c diabetes mellitus. | Sabrina L McIlwrath Karin N Westlund | 2015 | World Journal of Gastroenterology2015，21，3： | 2 |
| 5 | Knowledge discovery from models of soil properties developed through data mining显示文摘 | Elisabeth N B Brent L H Karin V | 2006 | Ecological Modelling2006，191，34： | 1 |
| 6 | Mamnudian MAP kinase signaling cascades 显示文摘 | Chang L Karin M | 2001 | Nature2001，410，6824： | 1 |
| 7 | Mammalian MAP kinase signaling cascades 显示文摘 | Chang L Karin M | 2001 | Nature2001，410，6824： | 1 |
| 8 | CD24 Is a N ew Oncogene,Early at the Mu ltistep Process of C olorectat Cancer Carcinogenes is显示文摘 | Sagiv E Memeo L Karin A | 2006 | Gastroenterology2006，131，2： | 1 |
| 9 | Forest pasturing of livestock in Norway: effects on spruce regeneration显示文摘Forest pasturing of free-roaming livestock is a common practice in many parts of the world, but knowledge on how it affects tree regeneration in boreal forests is lacking. We mapped tree density, livestock site use and accumulated damage to young trees of commercial interest(Norway spruce, Picea abies L. Karst.) on 56 clearcuts inside and outside a fenced forest area used for livestock pasturing in Ringsaker, Norway. Inside the fence 56±1.8% of spruce trees were damaged compared to 37±3.4% outside. Proportion of damaged spruce trees was positively related to cattle use of the clearcut, but not so for sheep. On the most intensively used clearcuts, four out of five trees were damaged. The density of deciduous trees was five times lower inside compared to outside of the fence(varying with plant species). While livestock grazing may reduce resource competition in favour of spruce, the current animal density clearly is impeding forest regeneration in the study area. | Olav Hjeljord Trond Hist?l Hilde Karine Wam | 2014 | Journal of Forestry Research2014，25，4： | 1 |
| 10 | Expression of cyclin-dependent kinase inhibitors p16MTS1,P21WAF1 and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas显示文摘 | Karin M L Alexandra K P | 2001 | Virchows Arch2001，439，： | 1 |
| 11 | Biochemical and transcriptomic analyses of two bovine skeletal muscles in Charolais bulls divergently selected for muscle growth显示文摘 | Karine S Isabelle C M Anne L | 2005 | Meat Science2005，70，2： | 1 |
| 12 | IKK/NF-kappa B signaling: balan- cing life and death - a new approach to cancer therapy显示文摘 | Luo J L Kamata H Karin M | 2005 | J Clin Invest2005，115，1： | 1 |
| 13 | Stability of lycopene in oil-in-water emulsions显示文摘 | KARIN A ESTHER M-M BETTINA L | 2003 | Eng Life Sci2003，3，4： | 1 |
| 14 | Mammalian MAP kinase signalling cascades 显示文摘 | Chang L Karin M | 2001 | Nature2001，410，6824： | 1 |
| 15 | Mammalian MAP kinase signalling cascades显示文摘 | Chang L Karin M | | 0，，6824： | 1 |
| 16 | Energy losses of superconducting power transmission cables in the grid显示文摘 | Jacob O Jan O Karin L | 2001 | IEEE Trans on Applied Superconductivity2001，11，1： | 1 |
| 17 | CD24 is a new oncogene early at the multistep process of colorectal cancer carcinogenesis 显示文摘 | Sagiv E Memeo L Karin A | 2006 | Gastroenterology2006，131，2： | 1 |
| 18 | In situ hybridization for the detection of cytomegalovirus (CMV) infection显示文摘 | Thomas L?ning Karin Milde Hans-Dieter Foss | 1986 | Virchows Archiv A Pathological Anatomy and Histopathology1986，，6： | 1 |
| 19 | Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators显示文摘 | Ana-Maria Bamberger Karin Milde-Langosch Elena R?ssing Christoph Goemann Thomas L?ning | 2001 | Journal of Cancer Research and Clinical Oncology2001，，9： | 1 |
| 20 | Sonochemi-cal approach to the synthesis of Fe3 04 @ Si02 core-shell nanoparticles with tunable properties 显示文摘 | Anne L M Sergei I N Karine G | 2008 | ACSnano2008，2，5： | 1 |
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