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| 1 | Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt显示文摘AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. | Nizar Saleh Abdelfattah Mohamed Amgad Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 8 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Effect of mucin production on survival in colorectal cancer:A case-control study显示文摘AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor stage.METHODS: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC. OS and TTP were compared among 4 groups divided according to mucin content: group A (50%-75% mucin), group B (75%-100% mucin), group C or controls (< 50% mucin). Group D consisted of all patients with tumors having < 75% mucin (controls and groups A together).RESULTS: Median survival in MCRC and NMCRC groups was 46.2 and 112.9 mo, respectively (P = 0.26). OS in groups A and B was 70.1 and 32.8 mo (P = 0.46), and in groups B and D was 32.8 and 70.1 mo, respectively (P = 0.143). TTP in MCRC and NMCRC was 50.17 and 44.77 mo, respectively (P = 0.795). TTP in groups A, B, and D was 70.1, 24.8, and 65.5 mo, respectively. Twenty-eight percent of patients with MCRC had poorly differentiated adenocarcinoma versus 8.6% in NMCRC patients (P = 0.028).CONCLUSION: MCRC is associated with a non-significant decrease in median survival and TTP, particularlywhen mucin content is > 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed. | Mirna H Farhat Kassem A Barada Ayman N Tawil Doha M Itani Hassan A Hatoum Ali I Shamseddine | 2008 | World Journal of Gastroenterology2008，14，45： | 6 |
| 4 | Aspirin use for primary prophylaxis: Adverse outcomes in non-variceal upper gastrointestinal bleeding显示文摘AIM: To compare outcomes of patients with nonvariceal upper gastrointestinal bleeding(NVUGIB) taking aspirin for primary prophylaxis to those not taking it.METHODS: Patients not known to have any vascular disease(coronary artery or cerebrovascular disease) who were admitted to the American University of Beirut Medical Center between 1993 and 2010 with NVUGIB were included. The frequencies of in-hospital mortality, re-bleeding, severe bleeding, need for surgery or embolization, and of a composite outcome defined as the occurrence of any of the 4 bleeding related adverse outcomes were compared between patients receiving aspirin and those on no antithrombotics. We also compared frequency of in hospital complications and length of hospital stay between the two groups.RESULTS: Of 357 eligible patients, 94 were on aspirin and 263 patients were on no antithrombotics(controlgroup). Patients in the aspirin group were older, the mean age was 58 years in controls and 67 years in the aspirin group(P < 0.001). Patients in the aspirin group had significantly more co-morbidities, including diabetes mellitus and hypertension [25(27%) vs 31(112%) and44(47%) vs 74(28%) respectively,(P = 0.001)], as well as dyslipidemia [21(22%) vs 16(6%), P < 0.0001).Smoking was more frequent in the aspirin group [34(41%) vs 60(27%), P = 0.02)]. The frequencies of endoscopic therapy and surgery were similar in both groups. Patients who were on aspirin had lower inhospital mortality rates(2.1% vs 13.7%, P = 0.002),shorter hospital stay(4.9 d vs 7 d, P = 0.01), and fewer composite outcomes(10.6% vs 24%, P = 0.01). The frequencies of in-hospital complications and re-bleeding were similar in the two groups.CONCLUSION: Patients who present with NVUGIB while receiving aspirin for primary prophylaxis had fewer adverse outcomes. Thus aspirin may have a protective effect beyond its cardiovascular benefits. | Karina M Souk Hani M Tamim Hussein A Abu Daya Don C Rockey Kassem A Barada | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 5 | Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance显示文摘 | D' Andrea FP Safwat A Kassem M | 2011 | Radiother On- col2011，99，3： | 1 |
| 6 | Enhancement of famotidine dissolu- tion rate through liquisolid tablets formulation:in vitro and In vivo evaluation显示文摘 | Fahmy R H Kassem M A | 2008 | Eur J Phartn Biopharm2008，69，： | 1 |
| 7 | Nanosuspension as an ophthalmic delivery system for certain glucocorticoid drugs 显示文摘 | KASSEM M A ABDEL RAHMAN A A GHORAB M M | 2007 | lnt J Pharm2007，340，12： | 1 |
| 8 | Leptin in pediatrics: a hormone from adipocyte that wheels several functions in children显示文摘 | Soliman AT Yasin M Kassem A | 2012 | Indian J Endocrinol Metab2012，16，3： | 1 |
| 9 | Integrated front-end receiver for a portable ultrasonic system显示文摘 | Sawan M Chebli R Kassem A | 2003 | Analog Integrated Circuits and Signal Processing2003，36，12： | 1 |
| 10 | Extending harvestseason,improving fruit quality and shelf life of ' Barhee'date palmby preharvest sprays显示文摘 | KASSEM H A AL-OBEED R S AHMED M A | 2010 | Acta Horticulturae2010，882，： | 1 |
| 11 | Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance 显示文摘 | D'Andrea F P Safwat A Kassem M | 2011 | Radiother Oncol2011，99，： | 1 |
| 12 | Nanosuspension as an ophthalmic delivery system for certain glucocorticoid drugs 显示文摘 | KASSEM M A ABDEL RAHMAN A A GHORAB M M | 2007 | Int J Pharm2007，340，12： | 1 |
| 13 | Some spectrometric methods for determination of certain antipyretic and antirheumatic drugs 显示文摘 | ISSA A S BELTAGY YA KASSEM M G | 1985 | Talanta1985，32，3： | 1 |
| 14 | Extendingharvest season?improving fruit quality and shelf life of'Barhee'date palm by preharvest sprays显示文摘 | KASSEM H A Al-OBEED R S AHMED M A | 2010 | Acta2010，882，： | 1 |
| 15 | Stability set of multiobjective nonlinear programming problems with fuzzy parameters in the consWaints显示文摘 | Kassem M Ammar A | 1995 | Fuzzy Sets and Systems1995，，74： | 1 |
| 16 | A new digital scan conversion architecture for ultrasonic imaging system 显示文摘 | KASSEM A SAWAN M BOUKADOUM M | 2005 | Journal of Circuits Systems and Computers2005，14，2： | 1 |
| 17 | Comparison of coupled and semicoupled numerical models for alluvial channels 显示文摘 | KASSEM A A CHAUDHRY M H | 1998 | Journal of Hydraulic Engineering1998，124，8： | 1 |
| 18 | Cancer stem ceU overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance显示文摘 | DANDREA FP SAFWAT A KASSEM M | 2011 | Radiother Oncol2011，99，3： | 1 |
| 19 | Mutational hotspots in the mitochondrial D-loop re- gion of cancerous and precancerous colorectal lesions in Egyptian patients显示文摘 | KASSEM A M EL-GUENDY N TANTAWY M | 2011 | DNA Cell Biol2011，30，： | 1 |
| 20 | Nanosuspension as an ophthalmic delivery system for certain glumcortimid drugs显示文摘 | Kassem M A Abdel Rahman A A Ghorab M M etal | 2007 | IntJ Pharm2007，3411，12： | 1 |
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