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	题名	作者	年代	出处	被引量
1	chemokine/chemokine receptor pair CC L20/CC R6 in humancolorectal malignancy:An overview显示文摘Chemokines belong to a superfamily of small, cytokinelike proteins, which induce multiple physiological functions, particularly cytoskeletal rearrangement and compartment-specific migration through their interaction with G-protein-coupled receptors. Chemokines and their receptors have been widely acknowledged as essential and selective mediators in leukocyte migration in inflammatory response. It is now established that the chemokine/chemokine receptor system is also used by cancer cells to direct lymphatic and haematogenous spreading and additionally has an impact on the site of metastatic growth of different tumours. In recent years an increasing number of studies have drawn attention to CC-chemokine cysteine motif chemokine ligand 20(CCL20) and its physiological sole receptor CCR6 to play a role in the onset, development and metastatic spread of various gastrointestinal cancer entities. Among various cancer types CCR6 was also demonstrated to be significantly overexpressed in colorectal cancer(CRC) and stimulation by its physiological ligand CCL20 has been reported to promote CRC cell proliferation and migration in vitro. Further, the CCL20/CCR6 system apparently plays a role in the organ-selective liver metastasis of CRC. Here we review the literature on expression patterns of CCL20 and CCR6 and their physiological interactions as well as the currently presumed role of CCL20 and CCR6 in the formation of CRC and the development of liver metastasis, providing a potential basis for novel treatment strategies.	Vilma Oliveira Frick Claudia Rubie Ulrich Keilholz Pirus Ghadjar	2016	World Journal of Gastroenterology2016，22，2：	8
2	Pathological features of rectal cancer after preoperative radiochemotherapy显示文摘	O. Dworak L. Keilholz A. Hoffmann	1997	International Journal of Colorectal Disease1997，，1：	2
3	Circulating tumor cells: the ' leukemic phase' of solid cancers显示文摘	Mocellin S Keilholz U Rossi CR	2006	Trends Mol Med2006，12，3：	1
4	Dielectric properties of highly filled thermoplastics for printed circuit boards显示文摘	Thomas Apeldorn C. Keilholz F. Wolff‐Fabris V. Altst?dt	2012	J. Appl. Polym. Sci2012，，6：	1
5	Erlotinib as 2nd and 3rd line monotherapy in patients with metastatic colorectal cancer:Results of a multi-center two cohort phase Ⅱ trial显示文摘	Keilholz U Arnold D Niederle N	2005	Proc Soc Clin Oncol2005，23，：	1
6	Pathological features of rectal cancer after preoperative radiochemotherapy 显示文摘	Dworak O Keilholz L Hoffmann A	1997	Int J Colorectal Dis1997，12，1：	1
7	LDH correlation with survival in advanced Melanoma from two large,randomised trials(Oblimersen GM301 and EORTC 18951)显示文摘	Agarwala S S Keilholz U Gilles E	2009	Eur J Cancer2009，45，10：	1
8	LDH correlation with survival in advanced melanoma from two large,randomised trials (Oblimersen GM301 and EORTC 18951) 显示文摘	Agarwala SS Keilholz U Gilles E	2009	Eur J Cancer2009，45，10：	1
9	Functional CCR9 expression is associated with small intestinal metastasis显示文摘	Letsch A Keilholz U Schadendorf D	2004	J Invest Dermatol2004，122，3：	1
10	Pathological features of rectal cancer after preoperative radiochemotherapy 显示文摘	Dworak O Keilholz L Hoffmann A	1997	Int J Colorectal Dis1997，12，：	1
11	Functional CCR9 expres- sion is associated with small intestinal metastasis 显示文摘	Letsch A Keilholz U Schadendorf D	2004	J Invest Derma-tol2004，122，3：	1
12	LDH correlation with survival in advanced melanoma from two large,randomised trials (Oblimersen GM301 and EORTC 18951)显示文摘	Agarwala SS Keilholz U Gilles E	2009	Eur J Cancer2009，45，10：	1
13	Circulating tumor cells: the leukemic phase of solid cancers 显示文摘	Mocellin S Keilholz U Rossi CR	2006	Trends Mol Med2006，，3：	1
14	Pathological features of rectal cancer after preoperative radiochemotherapy显示文摘	Dworak O Keilholz L Hoffmann A	1997	Int J Colorectal Dis1997，12，1：	1
15	Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1 显示文摘	Nussbaum A K Dick T P Keilholz W	1998	Proc Natl Acad Sci USA1998，95，12：	1
16	Clinical and immune responses of WT1-peptide vaccination in patients with acute myeloid leukemia ASCO Annual Meeting Proceedings显示文摘	Keilholz U Letsch A Asemissen A	2006	J Clin Oncol2006，24，：	1
17	Pathological features of rectal cancer after preoperative radiochemotherapy显示文摘	Dworak O Keilholz L Hoffmann A	1997	Int J Colorectal Dis1997，12，1：	1
18	LDH is a prognostic factor in stage IV patients but is a predictive factor only for bcl2 antisense efficacy: Re-analysis of GM301 and EORTC18951 randomized trials 显示文摘	Keilholz U Suciu S Bedikian CJ	2007	J Clin Oncol2007，25，：	1
19	A clinical and immunologic phase 2 trial of Wilms tumor gene product 1(WT1) peptide vaccination in patients with AML and MDS显示文摘	Keilholz U Letsch A Busse A	2009	Blood2009，113，26：	1
20	Systematic review of medical treatment in melanoma: current status and Future Prospects显示文摘	Garbe C Eigentler TK Keilholz U	2011	Oneologist2011，16，1：	1

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