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| 1 | The fate of aniline after a photo - Fenton reaction in an aqueous system containing iron( Ⅲ ), humic acid, and hydrogen peroxide显示文摘 | MASAMI F KENJI T KENGO M | 2000 | Environ Sci Technol2000，34，10： | 1 |
| 2 | CCR2 signaling contributes to lschemia-reperfusion injury in kidney 显示文摘 | Kengo F TakashiW Yasunori I | 2003 | J Am Soc Nephro2003，14，10： | 1 |
| 3 | A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease显示文摘AIM: To study a more accurate quantification of hepatic fibrosis which would provide clinically useful information for monitoring the progression of chronic liver disease. METHODS: Using a cDNA microarray containing over 22 000 clones, we analyzed the gene-expression profiles of non-cancerous liver in 74 patients who underwent hepatic resection. We calculated the ratio of azan- stained: total area, and determined the morphologic fibrosis index (MFI), as a mean of 9 section-images. We used the MFI as a reference standard to evaluate our method for assessing liver fibrosis. RESULTS: We identified 39 genes that collectively showed a good correlation (r > 0.50) between gene-expression and the severity of liver fibrosis. Many of the identified genes were involved in immune responses and cell signaling. To quantify the extent of liver fibrosis, we developed a new genetic fibrosis index (GFI) based on gene-expression profiling of 4 clones using a linear support vector regression analysis. This technique, based on a supervised learning analysis, correctly quantified the various degrees of fibrosis in both 74 training samples (r = 0.76, 2.2% vs 2.8%, P < 0.0001) and 12 independent additional test samples (r = 0.75, 9.8% vs 8.6%, P < 0.005). It was far better in assessing liver fibrosis than blood markers such as prothrombin time (r = -0.53), type Ⅳ collagen 7s (r = 0.48), hyaluronic acid (r = 0.41), and aspartate aminotransferase to platelets ratio index (APRI) (r = 0.38). CONCLUSION: Our cDNA microarray-based strategy may help clinicians to precisely and objectively monitor the severity of liver fibrosis. | Tohru Utsunomiya Masahiro Okamoto Shigeki Wakiyama Masaji Hashimoto Kengo Fukuzawa Takahiro Ezaki Shinichi Aishima Yasuji Yoshikawa Taizo Hanai Hiroshi Inoue Graham F Barnard Masaki Mori | 2007 | World Journal of Gastroenterology2007，13，3： | 1 |
| 4 | 显示文摘 | Kengo F Takashi W Yasunori I | 2002 | Nephrol Dial Transplant2002，17，3： | 1 |
| 5 | Photo- induced demulsification of emulsions using a photore- sponsive gemini surfactant显示文摘 | YUTAKA T KENGO F TATSUYA H | 2014 | Langmuir2014，30，1： | 1 |
| 6 | Degeneration after Sexual Differentiation in Hydra and its Relevance to the Evolution of Aging显示文摘 | KENGO Y TOSHITAKA F JUNG S H | 2006 | Gene2006，385，： | 1 |
| 7 | CCR2 signaling contributes to Ischemia-reperfusion injury in kidney 显示文摘 | Kengo F Takashi W Yasunori I | 2003 | J Am Soc Nephrol2003，14，10： | 1 |
| 8 | Flower color modu- lations of Toernia hybrida by downregulation of chaleon sysnthase genes with RNA interfernee 显示文摘 | Ei-ichiro F Kengo K Shin-ichiro K | 2004 | J Biotechnol2004，111，： | 1 |
| 9 | Interaction of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor(MCAF/MCP-1)显示文摘 | Takashi W Hitoshi Y Kengo F | 1996 | J Faseb1996，10，： | 1 |
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