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| 1 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 2 | Neuroendocrine tumors of the gastrointestinal tract: Case reports and literature review显示文摘Neuroendocrine tumors(NET)previously called carcinoid tumors are neoplasms of enterochromaffin/neuroendocrine cell origin which display neurosecretory capacity that may result in the carcinoid syndrome.The annual incidence of patients with NET is 8.4 per 100000;yet many NET remain asymptomatic and clinically undetected.A majority of NET follows a benign course;however,some will display malignant characteristics.NET most commonly occur in the gastrointestinal tract(67%)and bronchopulmonary system(25%).Gastrointestinal NET occur within the stomach,small intestine,liver,and rectum.We report a retrospective study of 11 subjects:Eight with benign carcinoid tumors:duodenal bulb(n=2),terminal ileum(n=1),sigmoid colon(n=2),and rectum(n=3);three with malignant carcinoid:liver(n=1)and intra-abdominal site(n=2).The diagnosis,endoscopic images,outcome,treatment and review of the literature are presented. | William J Salyers Kenneth J Vega Juan Carlos Munoz Bruce W Trotman Silvio S Tanev | 2014 | World Journal of Gastrointestinal Oncology2014，6，8： | 8 |
| 3 | Intestinal stem cells and the colorectal cancer microenvironment显示文摘Colorectal cancer(CRC)remains a highly fatal condition in part due to its resilience to treatment and its propensity to spread beyond the site of primary occurrence.One possible avenue for cancer to escape eradication is via stem-like cancer cells that,through phenotypic heterogeneity,are more resilient than other tumor constituents and are key contributors to cancer growth and metastasis.These proliferative tumor cells are theorized to possess many properties akin to normal intestinal stem cells.Not only do these CRC'stem'cells demonstrate similar restorative ability,they also share many cell pathways and surface markers in common,as well as respond to the same key niche stimuli.With the improvement of techniques for epithelial stem cell identification,our understanding of CRC behavior is also evolving.Emerging evidence about cellular plasticity and epithelial mesenchymal transition are shedding light onto metastatic CRC processes and are also challenging fundamental concepts about unidirectional epithelial proliferation.This review aims to reappraise evidence supporting the existence and behavior of CRC stem cells,their relationship to normal stem cells,and their possible dependence on the stem cell niche. | Bryan A Ong Kenneth J Vega Courtney W Houchen | 2014 | World Journal of Gastroenterology2014，20，8： | 2 |
| 4 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 5 | Modeling thermally thick pyrolysis of wood 显示文摘 | KENNETH M B KENNETH W R RUTLAND C J | 2002 | Biomass and Bioenergy2002，22，： | 1 |
| 6 | 显示文摘 | Lu W J Kenneth A D Andrew R | 2002 | J Appl Polym Sci2002，40，： | 1 |
| 7 | Manganesedependent cleavage of nonphenolic lignin structures byceriporiopsis subvermispora in the absence of ligninperox idase显示文摘 | Kenneth A Jensen J R Bao W L | 1996 | Applied and Environmental Microbiology1996，62，10： | 1 |
| 8 | The utilization of risk assessments in tactical command decisions 显示文摘 | WARREN W J KENNETH R S G BRUCE B | 2002 | Sei Total Environ2002，288，： | 1 |
| 9 | Testing and improving evapotranspiration and soil water balance of the DSSAT crop models显示文摘 | Federico S Kenneth J B Bostick W M | 2004 | Agronomy Journal2004，96，： | 1 |
| 10 | Modeling thermally thick pyrolysis of wood 显示文摘 | Kenneth Bryden M Kenneth Ragland W Christopher Rutland J | 2002 | Biomass and Bioenergy2002，22，： | 1 |
| 11 | Long - term clinieal and radio- graphic outcomes of cervical dise replacement with the prestige disc: results from a prospective randomized controlled clinical trial 显示文摘 | Kenneth J Regis W Vincent C | 2010 | J Neurosurg Spine2010，13，： | 1 |
| 12 | FNMR study of the reaction of P-fluorobenzenethiol and disulfide with periodate and other selected oxidizing agents显示文摘 | Evans Brian J Doi Joyce Takahashi Musker Kenneth W | 1990 | J Org Chem1990，55，： | 1 |
| 13 | Carbon monitoring costs and their effect on incentives to sequester carbon through forestry显示文摘 | OSCAR J C RUSSELL M W KENNETH G M | 2004 | Mitigation and Adaptation Strategies for Global Change2004，，154： | 1 |
| 14 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 15 | Accuracy and precision of cone-beam computed tomography guided intensity modulated radiation therapy 显示文摘 | Sutton M W Fontenot J D Kenneth I I | 2014 | Pract Radiat Oncol2014，4，4： | 1 |
| 16 | FNMR study of the reaction of p-fluorobenzenethiol and di- sulfide with periodate and other selected oxidizing agents 显示文摘 | Evans Brian J Doi Joyce Takahashi Musker Kenneth W | 1990 | J Org Chem1990，55，： | 1 |
| 17 | A CMOS integrated power detector for UWB 显示文摘 | KENNETH A TOWNSEND J W HASLETT J N | 2007 | IEEE Microwave and Wireless Components Letters2007，47，1： | 1 |
| 18 | Use of DNA bar- codes to identify flowering plants 显示文摘 | John W K Kenneth J W Elizabeth A Z | 2005 | PNAS2005，102，23： | 1 |
| 19 | Effect of load rate on flexural properties of wood-plastic composities显示文摘 | Brandt Chridtopher W Fridley Kenneth J | 2003 | Polymer-Plastics Technology and Fiber Science2003，35，1： | 1 |
| 20 | Manganesedependent cleavage of nonphenolic lignin structures byceriporiopsis subvermispora in the absence of ligninperox idase显示文摘 | Kenneth A Jensen J R Bao W L | 1996 | Applied and Environmental Microbiology1996，62，10： | 1 |
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