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| 1 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 2 | Accuracy Analysis of Stewart Platform Based on Interval Analysis Method显示文摘A Stewart platform is introduced in the 500 m aperture spherical radio telescope(FAST) as an accuracy adjustable mechanism for feed receivers.Accuracy analysis is the basis of accuracy design.However,a rapid and effective accuracy analysis method for parallel manipulator is still needed.In order to enhance solution efficiency,an interval analysis method(IA method) is introduced to solve the terminal error bound of the Stewart platform with detailed solution path.Taking a terminal pose of the Stewart platform in FAST as an example,the terminal error is solved by the Monte Carlo method(MC method) by 4 980 s,the stochastic mathematical method(SM method) by 0.078 s,and the IA method by 2.203 s.Compared with MC method,the terminal error by SM method leads a 20% underestimate while the IA method can envelop the real error bound of the Stewart platform.This indicates that the IA method outperforms the other two methods by providing quick calculations and enveloping the real error bound of the Stewart platform.According to the given structural error of the dimension parameters of the Stewart platform,the IA method gives a maximum position error of 19.91 mm and maximum orientation error of 0.534°,which suggests that the IA method can be used for accuracy design of the Stewart platform in FAST.The IA method presented is a rapid and effective accuracy analysis method for Stewart platform. | YAO Rui ZHU Wenbai HUANG Peng | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 27 |
| 3 | Three-dimensional hydrodynamic and water quality model for TMDL development of Lake Fuxian,China显示文摘Lake Fuxian is the largest deep freshwater lake in China.Although its average water quality meets Class I of the China National Water Quality Standard(CNWQS),i.e.,GB3838-2002,monitoring data indicate that the water quality approaches the Class II threshold in some areas.Thus it is urgent to reduce the watershed load through the total maximum daily load(TMDL) program.A three-dimensional hydrodynamic and water quality model was developed for Lake Fuxian,simulating flow circulation and pollutant fate and transport.The model development process consists of several steps,including grid generation,initial and boundary condition configurations,and model calibration processes.The model accurately reproduced the observed water surface elevation,spatiotemporal variations in temperature,and total nitrogen(TN),total phosphorus(TP),and chemical oxygen demand(COD) concentrations,suggesting a reasonable numerical representation of the prototype system for further TMDL analyses.The TMDL was calculated using two interpretations of the water quality standards for Class I of the CNWQS based on the maximum instantaneous surface and annual average surface water concentrations.Analysis of the first scenario indicated that the TN,TP and COD loads should be reduced by 66%,68% and 57%,respectively.Water quality was the highest priority;however,local economic development and cost feasibility for load reduction can pose significant issues.In the second interpretation,the model results showed that,under the existing conditions,the average water quality meets the Class I standard and therefore load reduction is unnecessary.Future studies are needed to conduct risk and cost assessments for realistic decision-making. | Lei Zhao Xiaoling Zhang Yong Liu Bin He Xiang Zhu Rui Zou Yuanguan Zhu | 2012 | Journal of Environmental Sciences2012，24，8： | 25 |
| 4 | Astragaloside IV inhibits spontaneous synaptic transmission and synchronized Ca^2+ oscillations on hippocampal neurons显示文摘目的: 在有教养的海马趾的 network.Methods 由 astragaloside IV (AGS-IV ) 导致了在自发的神经元易兴奋性调查变化: 在为 9-11 d 的文化的海马趾的神经原被用于这研究。这些海马趾的神经原的自发的接合的活动被 Ca^(2+) 成像和整个房间的斑夹钳技术检验。总共,当实验正在拿 place.Results 时,在 DMSO 和 2 mL/L DMSO 溶解的 40 mg/L AGS-IV 在一台显微镜下面被用于神经原: AGS-IV 禁止了同步自发的Ca^(2+)摆动的频率到59.39% ±3 .25%( mean+SEM ),自发的 postsynaptic 水流到43.78% ±7 .72%( mean+SEM ),和到控制时期的那些的49.25%+7.06%(吝啬的 ±S 他们)的自发的有刺激性的 postsynaptic 水流,分别地在 AGS-IV applications.AGS-IV 也减少了以后,在 16 min ,山峰在那时间 point.Conclusion 电压门K^+和Na^+隧道水流珍视:这些结果显示 AGS-IV 有效地压制自发的神经元易兴奋性。神经元活动的如此的调整能作为 neuroprotector 为 AGS-IV 代表新证据。 | Shao-qing ZHU Lei QI Yan-fang RUI Ru-xin LI Xiang-ping HE Zuo-ping XIE | 2008 | Acta Pharmacologica Sinica2008，29，1： | 23 |
| 5 | Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system显示文摘MicroRNAs (miRNAs ) 是内长的 noncoding RNA (~ 22 nt ) 在细胞质在 post-transcriptional 水平调整目标基因表示。在房间原子核的要求功能的 argonaute 家庭蛋白质提示了我们假设那 miRNAs 的 miRNAs 和 miRNA 的存在的最近的发现可以也在房间原子核有规章的功能。在这研究,我们证明老鼠 miR-709 主要位于各种各样的房间类型的原子核并且它的原子本地化模式很快在 apoptotic 刺激之上变化。在房间原子核, miR-709 直接在 pri-miR-15a/16-1 上绑在一个 19-nt miR-709 识别元素并且阻止它处理成 pre-miR-15a/16-1,导致 miR-15a/16-1 成熟的抑制。而且,原子 miR-709 通过 miR-15a/16-1 小径参予房间 apoptosis 的规定。在摘要,现在的学习提供一 miRNA 能由直接在原子核指向他们的主要抄本控制另外的 miRNAs 的生物的续生说的第一条证据。 | Rui Tang Limin Li Dihan Zhu Dongxia Hou Ting Cao Hongwei Gu Jing Zhang Junyuan Chen Chen-Yu Zhang Ke Zen | 2012 | Cell Research2012，22，3： | 23 |
| 6 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 7 | Genome Engineering in Rice Using Cas9 Variants that Recognize NG PAM Sequences显示文摘CRISPR/Cas9 genome editing relies on sgRNA-target DNA base pairing and a short downstream PAM sequence to recognize target DNA. The strict protospacer adjacent motif (PAM) requirement hinders applications of the CRISPR/Cas9 system since it restricts the targetable sites in the genomes. xCas9 and SpCas9-NG are two recently engineered SpCas9 variants that can recognize more relaxed NG PAMs, implying a great potential in addressing the issue of PAM constraint. Here we use stable transgenic lines to evaluate the efficacies of xCas9 and SpCas9-NG in performing gene editing and base editing in rice. We found that xCas9 can efficiently induce mutations at target sites with NG and GAT PAM sequences in rice. However, base editors containing xCas9 failed to edit most of the tested target sites. SpCas9-NG exhibited a robust editing activity at sites with various NG PAMs without showing any preference for the third nucleotide after NG. Moreover, we showed that xCas9 and SpCas9-NG have higher specificity than SpCas9 at the CGG PAM site. We further demonstrated that different forms of cytosine or adenine base editors containing SpCas9-NG worked efficiently in rice with broadened PAM compatibility. Taken together, our work has yielded versatile genome-engineering tools that will significantly expand the target scope in rice and other crops. | Kai Hua Xiaoping Tao Peijin Han Rui Wang Jian-Kang Zhu | 2019 | Molecular Plant2019，12，7： | 22 |
| 8 | Novel Strategy for Synthesis of High Quality CdTe Nanocrystals in Aqueous Solution显示文摘A novel aqueous route for the synthesis of high-quality CdTe nanocrystals(NCs) is presented in this article. With both glutathione(GSH) and cysteine[n(GSH):n(cysteine)=1:3] as stabilizers, high-quality CdTe NCs with controllable photoluminescence(PL) wavelength from 500 to 630 nm can be prepared within 4 h. As-prepared CdTe NCs show higher photoluminescence quantum yields(PLQY) compared with CdTe NCs prepared via other aqueous methods. When the fluorescent emission peak appeared in orange-red window, the PLQY reaches 70% or above at room temperature without any post-preparative treatment. | YAN Yu-xi MU Ying FENG Guo-dong ZHANG Lei ZHU Lin-lin XU Ling YANG Rui JIN Qin-han | 2008 | Chemical Research in Chinese Universities2008，24，1： | 21 |
| 9 | Serum sclerostin levels associated with lumbar spine bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis显示文摘 | XU Xiao-juan SHEN Lin YANG Yan-ping LU Fu-rong ZHU Rui SHUAI Bo LI Cheng-gang WU Man-xiang | 2013 | Chinese Medical Journal2013，，13： | 20 |
| 10 | Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway显示文摘Our previous study shows that nicotinamide adenine dinucleotide phosphate(NADPH)plays an important role in protecting against cerebral ischemia injury.In this study we investigated whether NADPH exerted cardioprotection against myocardial ischemia/reperfusion(I/R)injury.To induce myocardial I/R injury,rats were subjected to ligation of the left anterior descending branch of coronary artery for 30 min followed by reperfusion for 2 h.At the onset of reperfusion,NADPH(4,8,16 mg·kg?1·d?1,iv)was administered to the rats.We found that NADPH concentrations in plasma and heart were signi?cantly increased at 4 h after intravenous administration.Exogenous NADPH(8?16 mg/kg)signi?cantly decreased myocardial infarct size and reduced serum levels of lactate dehydrogenase(LDH)and cardiac troponin I(cTn-I).Exogenous NADPH signi?cantly decreased the apoptotic rate of cardiomyocytes,and reduced the cleavage of PARP and caspase-3.In addition,exogenous NADPH reduced mitochondrial vacuolation and increased mitochondrial membrane protein COXIV and TOM20,decreased BNIP3L and increased Bcl-2 to protect mitochondrial function.We conducted in vitro experiments in neonatal rat cardiomyocytes(NRCM)subjected to oxygen–glucose deprivation/restoration(OGD/R).Pretreatment with NADPH(60,500 nM)signi?cantly rescued the cell viability and inhibited OGD/R-induced apoptosis.Pretreatment with NADPH signi?cantly increased the phosphorylation of AMPK and downregulated the phosphorylation of mTOR in OGD/R-treated NRCM.Compound C,an AMPK inhibitor,abolished NADPH-induced AMPK phosphorylation and cardioprotection in OGD/R-treated NRCM.In conclusion,exogenous NADPH exerts cardioprotection against myocardial I/R injury through the activation of AMPK/mTOR pathway and inhibiting mitochondrial damage and cardiomyocyte apoptosis.NADPH may be a potential candidate for the prevention and treatment of myocardial ischemic diseases. | Jiang Zhu Yi-fei Wang Xiao-ming Chai Ke Qian Ling-wei Zhang Peng Peng Pei-min Chen Jian-fang Cao Zheng-hong Qin Rui Sheng Hong Xie | 2020 | Acta Pharmacologica Sinica2020，41，4： | 19 |
| 11 | The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer显示文摘Background:As a rate-limiting enzyme of glycolysis,pyruvate kinase muscle isozyme M2(PKM2)participates in tumor metabolism and growth.The regulatory network of PKM2 in cancer is complex and has not been fully studied in bladder cancer.The 5-methylcytidine(m5C)modification in PKM2 mRNA might participate in the pathogenesis of bladder cancer and need to be further clarified.This study aimed to investigate the biological function and regulatory mechanism of PKM2 in bladder cancer.Methods:The expression of PKM2 and Aly/REF export factor(ALYREF)was measured by Western blotting,qRT-PCR,and immunohistochemistry.The bioprocesses of bladder cancer cells were demonstrated by a series of experiments in vitro and in vivo.RNA immunoprecipitation,RNA-sequencing,and dualluciferase reporter assays were conducted to explore the potential regulatory mechanisms of PKM2 in bladder cancer.Results:In bladder cancer,we first demonstrated that ALYREF stabilized PKM2 mRNA and bound to its m5C sites in 3′-untranslated regions.Overexpression of ALYREF promoted bladder cancer cell proliferation by PKM2-mediated glycolysis.Furthermore,high expression of PKM2 and ALYREF predicted poor survival in bladder cancer patients.Finally,we found that hypoxia-inducible factor-1alpha(HIF-1α)indirectly up-regulated the expression of PKM2 by activating ALYREF in addition to activating its transcription directly.Conclusions:The m5C modification in PKM2 mRNA in the HIF-1α/ALYREF/PKM2 axis may promote the glucose metabolism of bladder cancer,providing a new promising therapeutic target for bladder cancer. | Jing-Zi Wang Wei Zhu Jie Han Xiao Yang Rui Zhou Hong-Cheng Lu Hao Yu Wen-Bo Yuan Peng-Chao Li Jun Tao Qiang Lu Ji-Fu Wei Haiwei Yang | 2021 | Cancer Communications2021，41，7： | 17 |
| 12 | Spatial characteristics of development efficiency for urban tourism in eastern China: A case study of six coastal urban agglomerations显示文摘传统的数据包封分析(DEA ) , bootstrap-DEA 和 Malmquist 模型被采用在东方中国在六沿海的城市的凝块测量不同旅游效率和他们 61 个城市的空间特征。下列结论被得出。(1 ) 用 bootstrap-DEA 模型的城市的旅游的全面效率(CE ) 是比用 DEA-CRS 模型的 CE 水平低的,它证实 DEA-CRS 模型的重要趋势过高估计结果。( 2 )在长江三角洲( YRD )和珀尔河三角洲( PRD )的城市的旅游的几何 CE 一般水准变化了从对无效自从 2000 有效,在 Beijing-Tianjin-Hebei ( BTH )和山东半岛( SDP )的一般水准变化了从对无效自从 2000 中等有效,并且自从 2000 ,在中央、南部的辽宁( CSL )和台湾海峡( WBTS )的西岸的那些是无效的。( 3 )在 PRD , YRD , BTH 和 SDP 的城市的旅游的 CE 价值被纯技术效率( PTE )稍微影响了,而自从 2000 ,在 CSL 和 WBTS 的 CE 价值被规模效率( SE )稍微影响了。( 4 )空间地,为 PRD , YRD , BTH , SDP , WBTS 和 CSL 的全部的因素生产率( TFP )的几何一般水准的范围顺序减少了,当为在六城市的凝块的大多数城市的展出了时一向下趋势自从 2000 。(5 ) 一起,自然条件,经济政策和旅游首都驾驶 CSL 和 WBTS 的城市的旅游的 SE 变化。为增加回来可伸缩并且模仿创新技术的旅游企业在 BTH 和 SDP 在城市的旅游的 CE 变化上有效果。旅游市场比赛在 PRD 和 YRD 驾驶城市的旅游的 PTE 变化。尽管 PTE 和在六沿海的城市的凝块的城市的旅游的 SE 受不了不明确的事件,自从 2000, CE 维持了全面健全动量。 | LI Rui GUO Qian WU Dianting YIN Hongmei ZHANG Hua ZHU Taoxing | 2014 | Journal of Geographical Sciences2014，24，6： | 16 |
| 13 | Enhancing both selectivity and coking-resistance of a single-atom Pd1/C3N4 catalyst for acetylene hydrogenation显示文摘选择加氢是在化学升级的一个重要工业催化过程,在因为他们的高加氢活动,基于 Pd 的催化剂广泛地被使用的地方。然而,因为重焦炭形成,差的选择和短催化剂一生是主要担心。在这个工作,原子地驱散 Pd 原子成功地在 graphitic 碳氮化物上被综合(g-C 3 用原子层免职的 N 4) 。没有 Pd nanoparticle (NP ) ,改正错误的高角度的环形的黑暗地的扫描传播电子显微镜学(HAADF 茎) 证实了孤立的 Pd 原子的主导的存在形成。在在过量乙烯的乙炔的选择加氢期间, g-C 3 N 4-supported Pd NP 催化剂比常规 Pd/Al 2 O 3 和 Pd/SiO 2 催化剂。在原处, X 光检查光致核裂变光谱学表明可观的费用从 Pd NP 转到 g-C 3 N 4 多半在催化表演改进起一个重要作用。更给人深刻印象地,单个原子的 Pd 1/C3 N 4 催化剂展出了两种更高的乙烯选择和更高的 coking 抵抗。我们的工作证明单个原子的 Pd 催化剂是在加氢反应改进选择和焦炭抵抗的一个有希望的候选人。 | Xiaohui Huang Yujia Xia Yuanjie Cao Xusheng Zheng Haibin Pan Junfa Zhu Chao Ma Hengwei Wang Junjie Li Rui You Shiqiang Wei Weixin Huang Junling Lu | 2017 | Nano Research2017，10，4： | 16 |
| 14 | Cytokeratin 19 fragment antigen 21-1 as an independent predictor for definitive chemoradiotherapy sensitivity in esophageal squamous cell carcinoma显示文摘 | YAN Hong-jiang WANG Ren-ben ZHU Kun-li JIANG Shu-mei ZHAO Wei XU Xiao-qing FENG Rui | 2012 | Chinese Medical Journal2012，，8： | 15 |
| 15 | Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta显示文摘胎盘为成功的怀孕和胎儿和怀孕女人的健康是关键的。然而,人的 trophoblast 系怎么被调整,包括胎盘的房间的分类,子类型糟糕被理解。这里,我们在排序的胎盘的房间上执行了定序的单个房间的 RNA (RNA-seq ) 从第一三个月并且秒三个月人胎盘。已知的 cytotrophoblast 房间(CTB ) 的房间的新子类型, extravillous trophoblast 房间(EVT ) , Hofbauer 房间,和间充质的 stromal 房间被识别, cell-type-specific 基因签名被定义。机能上地,这研究揭示了人的胎盘的许多以前未知的功能。尤其是, 102 多肽荷尔蒙基因被发现被胎盘的房间的各种各样的子类型表示,它在调整母亲的生理学的胎儿的生长和改编到怀孕建议建筑群和这些荷尔蒙的重要角色。这些结果在单个房间的分辨率记录人的胎盘的 trophoblast 区别并且因此在怀孕的早阶段期间推进我们人的胎座式的理解。 | Yawei Liu Xiaoying Fan Rui Wang Xiaoyin Lu Yan-Li Dang Huiying Wang Hai-Yan Lin Cheng Zhu Hao Ge James C. Cross Hongmei Wang | 2018 | Cell Research2018，28，8： | 15 |
| 16 | Primary duct closure versus T-tube drainage after laparoscopic common bile duct exploration:a meta-analysis显示文摘Background and aims:Laparoscopic common bile duct exploration(LCBDE)is considered a safe and effective method for the removal of bile duct stones.However,the choice of primary duct closure(PDC)or T-tube drainage(TTD)technique after LCBDE is still controversial.This study aimed to compare the safety and effectiveness of PDC and TTD after LCBDE.Methods:Studies published before May 1,2021 in Pub Med,Web of Science,and Cochrane Library databases were searched to screen out randomized controlled trials(RCTs)and cohort studies to compare PDC with TTD.Meta-analyses of fixed effect and random effect models were performed using Rev Man 5.3.Results:A total of 1865 patients were enrolled in six RCTs and ten cohort studies.Regarding RCTs,the PDC group was significantly better than the TTD group in terms of operation time,total postoperative complications,postoperative hospital stay,and hospitalization expenses(all P<0.05).Based on cohort studies of the subgroup,the PDC group had shorter operation time,shorter postoperative hospital stay,less intraoperative blood loss,and limited total postoperative complications.Statistically,there were no significant differences in bile leakage,retained stones,stone recurrence,bile duct stricture,postoperative pancreatitis,other complications,or postoperative exhaust time between the TTD and PDC groups.Conclusions:Based on the available evidence,compared with TTD,PDC is safe and effective,and can be used as the first choice after transductal LCBDE in patients with choledocholithiasis. | Taifeng ZHU Haoming LIN Jian SUN Chao LIU Rui ZHANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，12： | 15 |
| 17 | The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy显示文摘在母亲 / 胎儿的接口的 Th2 偏爱的规章的机制仍然保持不清楚。在这研究,我们在蜕膜的 stromal 描绘了 cytokine 生产房间(DSC ) ,蜕膜的有免疫力的房间(DIC ) 和导出胚胎的 trophoblast 房间,并且在早人的怀孕在母亲 / 胎儿的接口在 Th2 偏爱上调查了 CXCL12/CXCR4 相互作用的规定。我们由 trophoblasts, DSC 和 DIC 发现了 Th1 类型和 Th2 类型 cytokines 的微分生产。这些 cytokines 的分泌物在不同房间 cocultures 变化了,导致了到 Th2 偏爱。流动 cytometry 与 DSC 显示出 trophoblasts 的那 coculture, DIC 显著地在 DSC 在 trophoblasts,和 IL-10 生产增加了 IL-4 和 IL-10 生产。然而,有 DSC 和 DIC 的 trophoblasts 的 coculture 显著地增加了干扰素(IFN )-γ在 DSC,和肿瘤坏死因素(TNF )-α 的表示;在 DIC 的表示。没有变化在所有 cocultures 在 DIC 在 trophoblasts,并且在 Th2 类型 cytokine 生产在 Th1 类型 cytokine 生产被看见。而且,有抵销抗体 upregulated 的 anti-CXCR4 的预告的处理 Th1 类型 cytokines IFN-γ 的生产;并且 TNF-α,并且 downregulated Th2 类型 cytokines IL-4 和 IL-10 的生产在 trophoblasts, DSC, DIC 或他们的 cocultures。有趣地, rhCXCL12 禁止了 Th1 类型 cytokine TNF-α 的生产;并且在 DIC 提高了象 IL-4 和 IL-10 那样的 Th2 类型 cytokines 的表示;这效果被 anti-CXCR4 抗体废除。我们的现在的学习阐明了到塑造 Th2 的部件房间的单个贡献偏导,并且揭开经由在在早人的怀孕的母亲 / 胎儿的接口的 CXCL12/CXCR4 信号的复杂串音。 | Hai-Lan Piao Yu Tao Rui Zhu Song-Cun Wang Chuan-Ling Tang Qiang Fu Mei-Rong Du Da-Jin Li | 2012 | Cellular & Molecular Immunology2012，9，5： | 14 |
| 18 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 19 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 20 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
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