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| 1 | Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells显示文摘Sorafenib is currently the standard chemotherapy drug for treatment of advanced hepatocellular carcinoma(HCC).But its efficacy requires improvement,it is imperative to seek therapeutic strategies that combine sorafenib with other anticancer agents.In this study we investigated the synergistic anticancer effect of combining sorafenib and artesunate,an anti-malaria drug derivative,against HCC in vitro and in vivo.We first showed that artesunate(1–100μM)alone dose-dependently inhibited the proliferation of five HCC cell lines tested with IC50 values of around 100μM.Artesunate treatment dose-dependently increased the ROS level in both HuH7 and Hep3B cells;addition of NAC significantly ameliorated the antiproliferation effect of artesunate against HuH7 and Hep3B cells.Then we demonstrated that combination of sorafenib and artesunate exerted synergistic antiproliferation effect and induced synergistic apoptosis in HCC cell lines.In nude mice bearing Hep3B xenografts,combined administration of sorafenib and artesunate significantly enhanced the suppression on tumor growth.We further revealed that sorafenib dose-dependently decreased the levels of p-ERK and p-STAT3,whereas artesunate markedly increased the levels of p-ERK and p-STAT3 in HuH7 and Hep3B cells.When used in combination,sorafenib abolished artesunate-elevated levels of p-STAT3 and p-ERK.Moreover,pharmacological inhibition of ERK by inhibitor PD0325901 or STAT3 by inhibitor Stattic markedly enhanced the anticancer activity of artesunate,suggesting that suppression of ERK and STAT3 signaling by sorafenib contributes to the synergistic anticancer activity against HCC caused by combination of sorafenib and artesunate.Taken together,our results provide an evidence for possible use of sorafenib plus artesunate or artemisinin analogs for treatment of HCC in the future. | Xu Yao Chen-ru Zhao Hao Yin KeWei Wang Jian-jun Gao | 2020 | Acta Pharmacologica Sinica2020，41，12： | 7 |
| 2 | The structural,electronic and magnetic properties of the 3d TM(V,Cr,Mn,Fe,Co,Ni and Cu) doped ZnO nanotubes:A first-principles study显示文摘We have performed the first-principles calculations onto the structural,electronic and magnetic properties of seven 3d transition-metal(TM=V,Cr,Mn,Fe,Co,Ni and Cu) atom substituting cation Zn in both zigzag(10,0) and armchair(6,6) zinc oxide nanotubes(ZnONTs).The results show that there exists a structural distortion around 3d TM impurities with respect to the pristine ZnONTs.The magnetic moment increases for V-,Cr-doped ZnONTs and reaches maximum for Mn-doped ZnONTs,and then decreases for Fe-,Co-,Ni-and Cu-doped ZnONTs successively,which is consistent with the predicted trend of Hund's rule for maximizing the magnetic moments of the doped TM ions.However,the values of the magnetic moments are smaller than the predicted values of Hund's rule due to strong hybridization between p orbitals of the nearest neighbor O atoms of ZnONTs and d orbitals of the TM atoms.Furthermore,the Mn-,Fe-,Co-,Cu-doped(10,0) and(6,6) ZnONTs with half-metal and thus 100% spin polarization characters seem to be good candidates for spintronic applications. | ZHANG JianMin GAO Dan XU KeWei | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，3： | 5 |
| 3 | Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling显示文摘Sorafenib,酷氨酸蛋白质 kinases 的一个小禁止者,当前是为先进 hepatocellular 癌(HCC ) 的治疗的标准化疗药。尽管 sorafenib 改进 HCC 病人的幸存,它的功效不是最佳的并且要求进一步的改进。Capsaicin,从类辣椒的红辣椒辣椒的主要活跃部件,是 TRPV1 隧道,而且显示 antitumor 活动的不仅收缩筋并且提高癌症房间的敏感到细胞毒素的药。在这研究,我们在 vitro 和异种皮移植肿瘤在 HCC 房间上调查了联合 sorafenib 和 capsaicin 的 antitumor 效果。有 capsaicin 的治疗 dose-dependently 独自分别地与 137, 108 和 140.7 mol/L 的 IC 50 价值禁止了 HCC 房间线 PLC/PRF/7, HuH7 和 HepG2 的增长。TRPV1 隧道的明显的表示都没在 3 根 HCC 房间线被检测, TRPV1 隧道 blockers 没减轻 capsaicin 的 cytotoxicity。由对比,显著地联合 capsaicin 和 sorafenib 在房间增长上提高了抑制,完成高级 synergistic 效果(超过 50% 的抑制率) 并且支持 HCC 房间 apoptosis。在有 PLC/PRF/5 异种皮移植的裸体老鼠,联合了 capsaicin 的管理,没有明显的粗野毒性, sorafenib 显著地独自与任何一个代理人相比在肿瘤生长上提高了抑制。机械学地, capsaicin (10-200 mol/L ) dose-dependently 在 PLC/PRF/5 房间增加了 phosphorylated 英皇家空军之阶级最低之兵(津贴) 的层次,因此导致在肿瘤房间上提高了 sorafenib 敏感和 synergistic 抑制。一起拿,我们的结果建议英皇家空军之阶级最低之兵的增加 capsaicin 的 phosphorylation 贡献 sorafenib,和 capsaicin 的提高的 antitumor 活动可能在为 HCC 的处理改进 sorafenib 的功效有用。 | Su-shan ZHANG Yu-hao NI Chen-ru ZHAO Zhen QIAO Hong-xia YU Lu-yao WANG Jin-yan SUN Chen DU Jia-haoZHANG Li-ying DONG KeWei WANG Jian-jun GAO | 2018 | Acta Pharmacologica Sinica2018，39，3： | 4 |
| 4 | Investigation of stress corre-sion cracking under anodic dissolution control显示文摘This review is about stress corrosion cracking (SCC) under anodic dissolution control. The section 1 is the methods distinguishing SCC controlled by anodic dissolution from those by hydrogen. The section 2 presents hydrogen-enhanced corrosion and SCC under anodic dissolution control. The section 3 demonstrates corrosion-enhanced localized plasticity and corrosion-induced deformation localization, which are the fundaments of new mechanism of SCC. The section 4 is an overview of the proposed mechanisms of SCC under anodic dissolution control. The last section proposes a new mechanism of SCC. | Wuyang Chu Lijie Qiao Kewei Gao | 2001 | Chinese Science Bulletin2001，46，9： | 4 |
| 5 | Mechanism of protective film formation during CO_2 corrosion of X65 pipeline steel显示文摘Electrochemical techniques, X-ray diffraction (XRD), and scanning electron microscopy (SEM) were applied to study the corrosion behaviors of X65 steel in static solution with carbon dioxide (CO2) at 65°C. The results show that iron carbonate (FeCO3) deposits on the steel surface as a corrosion product scale. This iron carbonate scale acts as a barrier to CO2 corrosion, and can reduce the general corrosion rate. The protection ability of the scale is closely related to the scale morphological characteristics. | Tong Li Yonggjin Yang Kewei Gao Minxu Lu | 2008 | Journal of University of Science and Technology Beijing2008，15，6： | 2 |
| 6 | Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration显示文摘Oncostatin M (OSM ) 是 interleukin-6 家庭的 cytokine 并且在发炎期间起重要作用。然而,它在 myoblast 区别的角色和肌肉新生仍然保持未经勘探。我们这里证明 OSM potently 主要由激活 JAK1/STAT1/STAT3 小径禁止了 myoblast 区别。OSM downregulated myocyte 提高有约束力的因素 2A (MEF2A ) , upregulated Id1 和 Id2 的表示,并且禁止了 MyoD 和 MEF2 的 transcriptional 活动。另外, OSM 也提高了 STAT3 和 OSM 受体的表示,它组成了一个积极反馈环进一步放大导致 OSM 的发信号。而且,我们发现身体上与 MEF2 联系并且镇压的那 STAT1 它的 transcriptional 活动,它能说明 MEF2 的调停 OSM 的压抑。尽管在在 vivo 的正常肌肉无法发现, OSM 很快在肌肉损害上然后即时被导致就在 myoblasts 的多数前的 downregulated 区分。没有影响 myoblast 增长,在肌肉的 OSM 的延长表示损害了新生进程,建议 OSM 工作阻止增殖的 myoblasts 在肌肉新生的早阶段期间的早熟的区别。 | Fang Xiao Haixia Wang Xinrong Fu Yanfeng Li Kewei Ma Luguo Sun Xiang Gao Zhenguo Wu | 2011 | Cell Research2011，21，2： | 2 |
| 7 | Film-induced Tensile Stress during CorrosionProcess for α-Ti显示文摘The α-Ti foil with protective layer in one side bended to corrosion surface gradually during corrosion process in 0.1 mol/L H2SO4, while the passive film was formed, i.e., a tensile stress was developed in the surface layer of the sample. The extra tensile Stress grew gradually, whose maximum value is =313 MPa (average of 5 samples), which is near or reaches the yield stress. The extra tensile stress would be added to the load Stress during SCC to facilitate the emission and motion of dislocation, so that SCC cracks could nucleate in lower Stress(or lower KI). | Hong LU Kewei GAO and Wuyng CHU(Dept. of Materials Physics, University of Science and Technology Beijing, Beijing 100083, China) | 1998 | Journal of Materials Science & Technology1998，14，4： | 2 |
| 8 | The relationship between fracture toughness of CO 2 corrosion scale and corrosion rate of X65 pipeline steel under supercritical CO 2 condition显示文摘 | Yucheng Zhang Xiaolu Pang Shaopeng Qu Xin Li Kewei Gao | 2011 | International Journal of Greenhouse Gas Control2011，，6： | 2 |
| 9 | An investigation of corrosion-induced stress during SCC显示文摘TEM (Transmission Electron Microscope) observations show that corrosion process during stress corrosion cracking (SCC)enhances dislocation emission and motion; and microcrack of SCC initiates when the corrosion-enhanced dislocation emission and motion reaches a certain condition. The passive film or dealloyed layer formed during corrosion or SCC can induce a large tensile stress,which can assist the applied stress to enhance dislocation emission and motion, and then SCC occurs. Experiments show that the variation of SCC susceptibility of brass, α-Ti and stainless steel with the applied potential and pH value of the solution is consistent with that of the corrosion-induced additive stress. Molecular dynamics simulations show that a dealloyed layer can generate a tensile stress; and the corrosion (dealloyed layer)-induced tensile stress can assist the applied stress to enhance dislocation emission and crack propagation. | Wuyang Chu, Kewei Gao, Lijie Qiao, and Yue ZhangDepartment of Materials Physics, University of Science and Technology Beijing, Beijing 100083, China | 2003 | Journal of University of Science and Technology Beijing2003，10，1： | 2 |
| 10 | Initiating,growing and cracking of hydrogen blisters显示文摘The growing process of a hydrogen blister in a wheel steel was observed in situ with an optical microscope, and the fracture surfaces formed from broken blisters on a wheel steel and bulk metallic glass were investigated. The initiating, growing, cracking and breaking of hydrogen blis-ters are as follows. Supersaturated vacancies can increase greatly during charging and gather together into a vacancy cluster (small cavity). Hydrogen atoms become hydrogen molecules in the vacancy cluster and hydrogen molecules can stabilize the vacancy cluster. The small cavity becomes the nucleus of hydrogen blister. The blister will grow with enter-ing of vacancies and hydrogen atoms. With increasing hy-drogen pressure, plastic deformation occurs first, the hydro-gen blister near the surface extrudes, and then cracks initiate along the wall of the blister with further increasing hydrogen pressure. A cracked blister can grow further through propa-gating of cracks until it breaks. | REN Xuechong SHAN Guangbin CHU Wuyang SU Yanjing GAO Kewei QIAO Lijie JIANG Bo CHEN Gang CUI Yinhui | 2005 | Chinese Science Bulletin2005，50，17： | 2 |
| 11 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 12 | Three-dimensional molecular dynamics simulation of hydrogen-enhanced dislocation emission and crack propagation显示文摘A three-dimensional molecular dynamics simulation using the embedded atom method (EAM) potentials shows that for both pure Ni and Ni+H, dislocations are firstly emitted during loading and the crack propagates after enough disloca tions are emitted. In the case of hydrogen embrittlement, local plastic deformat ion is a precondition for crack propagation. For the crack along the (1 11) slip pla ne, one atom fraction in percent of hydrogen can decrease the critical stress in tensity for dislocation emission KIe from 0.42 to 0.36 MPam 1/2, and that for crack propagation KIp from 0.80 to 0.76 MPam1/2. Therefore, hydrogen enhances dislocation emission and crack pro pagation. | LI Zhongji, CHU Wuyang, LI Jinxu, GAO Kewei and QIAO Lijie(Department of Materials Physics, University of Science and Technology Beijing, Beijing 100083, China) | 2002 | Progress in Natural Science:Materials International2002，12，9： | 1 |
| 13 | An anatomical, histopathological, and molecular biological function study of the fascias posterior to the interperitoneal colon and its associated mesocolon: their relevance to colonic surgery显示文摘 | Zhidong Gao Yingjiang Ye Weiguang Zhang Danhua Shen Yanfeng Zhong Kewei Jiang Xiaodong Yang Mujun Yin Bin Liang Long Tian Shan Wang | 2013 | J. Anat2013，，： | 1 |
| 14 | Effect of Hydrogen on Dezincification Layer-Induced Stress显示文摘The effect of hydrogen on the dezincification layer-induced stress and the susceptibility to SCC was investigated.Experimental results showed that the dezincification layer-induced stress increased with increasing hydrogen concen-tration, and 3×10-6 hydrogen could increase the susceptibility to SCC of brass in ammonia solution by 10%. | Wuyang CHU, Kewei GAO, Yapin LIU Lijie QIAODepartment of Materials Physics, University of Science and Technology Beijing, Beijing 100083, China | 2003 | Journal of Materials Science & Technology2003，19，3： | 1 |
| 15 | Overexpression of an H+ - PPase Gene from Thellungiella halophila in Cotton Enhances SaltTolerance and Improves Growth and Photosynthetic Performance显示文摘 | SulianLv Kewei Zhang Qiang Gao | 2008 | Plant Cell Physiol2008，49，8： | 1 |
| 16 | Cyclic bonding strength for hard coatings and the effect of residual stresses显示文摘 | GAO Runshen XU Kewei HE Jiawen | 1993 | Chinese Journal of Mechanical Engineering1993，6，1： | 1 |
| 17 | Stress Corrosion Cracking and Passive Film-inducedTensile Stress in α-Ti显示文摘α-Ti foil with a protective layer formed on one side was deflected during corrosion in a methanol solution containing 0.6 mol/L KCI and then a tensile stress was generated at or near the metal passive film interface. The in situ TEM observation showed that corrosion process could facil- itate dislocation emission and motion. Adding 10% H2O into the methanol solution decreased the passive film-induced stress from 320 MPa to zero, and the susceptibility to SCC measured in slow strain rate tests decreased correspondingly from 98% to zero. | Hong LU Kewei GAO, Hui LIU Lijie QIAO and Wuyang CHU Dept. of Materials Physics, University of Science and Technology Beijing, Beijing 100083, China | 2001 | Journal of Materials Science & Technology2001，17，4： | 1 |
| 18 | Discussion of the CO 2 corrosion mechanism between low partial pressure and supercritical condition显示文摘 | Yucheng Zhang Xiaolu Pang Shaopeng Qu Xin Li Kewei Gao | 2012 | Corrosion Science2012，，： | 1 |
| 19 | Mg-based inorganic nanofibers constructing fast and multi-dimensional ion conductive pathways for all-solid-state lithium metal batteries显示文摘Solid-state electrolytes(SSEs),which replace flammable and toxic liquid electrolytes,have attracted widely attention.However,there exist still some challenges in actual application such as poor interfacial compatibility and slow ionic migration.In this study,Mg O nanofibers and MgF;nanofibers were prepared via the electro-blow spinning and high-temperature calcination methods,and were applied to all-solid-state lithium metal batteries for the first time.The organic-inorganic composite SSEs exhibited continuous conduction paths based on the virtue of the nanofibers with high length-to-diameter ratio,which were designed and prepared by mixing prepared fillers into the poly(ethylene oxide)(PEO)/lithium bis(trifluoromethane)sulfonilimide(Li TFSI)system.The effect of filler with different morphologies,doping ratios and component on ionic conductivity,electrochemical stability and cycle performance were explored under two kinds of[EO]/[Li^(+)]ratios and ambient temperatures.The ionic conductivities of electrolytes containing Mg O and MgF;nanofibers can reach up to 1.19×10^(-4) and 1.39×10^(-4) S cm^(-1) at 30℃,respectively.They were attributed to specific ionic conductive enhancement at the organicinorganic interface,reduced crystallinity and Lewis acid interaction,which can effectively promote the dissociation of the lithium salts.Especially MgF_(2) nanofiber,combining low electronic conductance,excellent electrochemical stability and outstanding inhibition for lithium dendrites of fluorides,endowed the battery with an initial specific capacity of 140.6 m Ah g^(-1) and capacity decay rate per cycle of 0.055%after500 cycles at 50℃.The work can provide an idea to design SSE with fast and multi-dimensional Li conductive paths and excellent interfacial compatibility. | Wen Yu Nanping Deng Zirui Yan Lu Gao Kewei Cheng Xiaohui Tian Lin Tang Bowen Cheng Weimin Kang | 2022 | Journal of Energy Chemistry2022，31，4： | 1 |
| 20 | Enhanced Thermoelectric Transport Properties of La0.98Sr0.02CoO3-BiCuSeO Composite显示文摘 | Muhammad Umer Farooq Ziyuan Gao Sajid Butt Kewei Gao Xiaolu Pang Hidayat Ullah Shah Hasnain Mehdi Jafri Asif Mahmod Xigui Sun Nasir Mahmood | 2016 | Journal of Electrical Engineering2016，4，2： | 1 |
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