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| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | Validated questionnaire on diagnosis and symptom severity functional constipation in the Chinese population 显示文摘 | Chan AO Lam KF Hui WM | 2005 | Aliment Pharmacol2005，5，22： | 1 |
| 3 | A validated symptoms questionnair (Chinese GERDQ) for the diagnosis of gastroesophageal reflux disease in the Chinese population显示文摘 | Wong WM Lam KF Lai KC | 2003 | Aliment Pharmocol Ther2003，17，： | 1 |
| 4 | Attitudes of primary care phy- sicians towards patients with mental illness in Hong Kong显示文摘 | Lam TP Lam KF Lam EW | 2013 | Asia Pac Psychiatry2013，5，1： | 1 |
| 5 | Prevalence of eo- loreetal neoplasm among patients with newly diagnosed coronary artery disease显示文摘 | Chan AO Jim MH Lam KF | 2007 | JAMA2007，298，12： | 1 |
| 6 | Gastrointestinal bleed ing in patients receiving a combination of aspirin, clopi dogrel,and enoxaparin in acute coronary syndrome 显示文摘 | Ng FH Wong SY Lam KF | 2008 | Am J Gastroenterol2008，103，4： | 1 |
| 7 | A validated symptoms questionnair (Chinese GERDQ)for the diagnosis of gastroesophageal reflux disease in the Chinese population 显示文摘 | Wong WM Lam KF Lai KC | 2003 | Aliment Pharmocol Ther2003，17，： | 1 |
| 8 | Determination of micro- eystins in cyanobacterial blooms by solid-phase microextraction- high-performance liquid chromatography 显示文摘 | Pooh KF Lam MH Lain PK | 2001 | Environ Toxicol Chem2001，20，8： | 1 |
| 9 | Stercoral perforation ofthe sigmoid colon with faecal peritonitis : report of two ca-ses显示文摘 | Lam CH Lo LW Ma KF | 2013 | HK J Radiol2013，16，4： | 1 |
| 10 | A frequent activated smoothened mutation in sporadic basal cell carcinomas 显示文摘 | Lam CW Xie J To KF | 1999 | Oncogene1999，18，3： | 1 |
| 11 | Quality of life and psychologicalimpact in patients with noncardiac chest pain显示文摘 | Cheung TK Hou X Lam KF | 2009 | J Clin Gastroenterol2009，43，1： | 1 |
| 12 | Coexistence between colorectal cancer/adenoma and coronary artery disease:results from 1382 patients显示文摘 | Chan AO Lam KF Tong T | 2006 | Aliment Pharmacol Ther2006，24，3： | 1 |
| 13 | A validated symptoms q u e s t i o n n a i r(C h i n e s e G E R D Q)f o r t h e d i a g n o s i s o f gastroesophageal refl ux disease in the Chinese population显示文摘 | Wong WM Lam KF Lai KC et a1 | 2003 | Aliment Pharmocol Ther2003，17，： | 1 |
| 14 | Gastroesophageal reflux disease is associated with poor asthma control,quality of life,and psychological status in Chinese asthma patients显示文摘 | Cheung TK Lam B Lam KF | 2009 | Chest2009，135，5： | 1 |
| 15 | Natural history of pelvic lym- phocystsas observed by ultra-sonography after bilateral pelvic lymphadenectom显示文摘 | Tam KF Lam KW Chan KK | 2008 | Ultrasound Obstet Gynecol2008，32，2： | 1 |
| 16 | Natural history of pelvic lymphocysts as observed by ultrasonography after bilateral pelvic lymphadenectomy显示文摘 | Tam KF Lam KW Chan KK | 2008 | Ultrasound Obstet Gynecol2008，32，1： | 1 |
| 17 | A validated symptoms questionnaire (Chinese GERDQ) for the diagnosis of gastro-oesophageal reflux disease in the Chinese population显示文摘 | Wong WM Lam KF Lai KC | 2003 | Aliment Pharmacol Ther2003，17，： | 1 |
| 18 | A long non-coding RNA signature in glioblastoma multiforme predicts survival 显示文摘 | Zhang XQ Sun S Lam KF | 2013 | Neurobiol Dis2013，58，： | 1 |
| 19 | Gastrointestinal bleeding inpatients receiving a combination of aspirin, clopidogrel andenoxaparin in aeute coronary syndrome显示文摘 | Ng FH Wong SY Lam KF | 2008 | Am JGastroenterol2008，103，4： | 1 |
| 20 | The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype HSN1-a review显示文摘 | Ng WF To KF Lam WW | 2006 | Hum Pathol2006，37，4： | 1 |
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