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| 1 | 局部中晚期食管癌的多学科整合治疗显示文摘虽然手术是局限性食管癌的主要治疗手段,但初诊时可行根治性手术治疗的患者仅占总数的30%~40%,且根治手术后患者5年总生存率仅为15%~20%;放射治疗是食管癌的另一种局部治疗手段,但仅接受单一放疗的局限性食管癌患者预后不佳。手术、放疗与化疗的联合应用目前被认为是提高食管癌根治疗效的重要途径。本文总结并分析了近年来局限性食管癌的多学科整合治疗的方法及疗效,并根据多项Ⅲ期临床研究及荟萃分析的结果提供以下治疗建议:临床Ⅰ期、ⅡA期的食管癌推荐直接给予根治性手术(除颈段食管癌);局部中晚期食管癌可考虑同期诱导放化疗后行根治性手术。以顺铂为基础的同期放化疗目前是无法手术的局部中晚期食管癌的推荐治疗手段。对已接受手术但肿瘤未被完全切除或手术切缘阳性者,应予以根治剂量的辅助同期放化疗。 | 陆嘉德 Lee Khai Mun | 2008 | 中国癌症杂志2008，18，5： | 19 |
| 2 | Helicobacter pylori γ-glutamyl transpeptidase:A formidable virulence factor显示文摘Helicobacter pylori(H.pylori)produce an enzyme known asγ-glutamyl transpeptidase(HpGGT)that is highly conserved and common to all strains.HpGGT has been gaining increasing attention as an important virulence factor of the bacterium,having been demonstrated to be an important colonization factor in several animal models and has also recently been strongly associated with the development of peptic ulcer disease.From the results of various independent researcher groups,it is clear that HpGGT acts through several pathways to damage gastric epithelial cells including the induction of apoptosis and cell cycle arrest,production of reactive oxygen species leading to DNA damage,promotion of inflammation by increasing cyclooxygenase-2 and interleukin-8 expression,and upregulation of heparin-binding epidermal growth factor-like growth factor resulting in cell survival and proliferation.In addition,the potential role of HpGGT in promoting gastric carcinogenesis will also be discussed in this review.Apart from affecting the gastric epithelium,HpGGT also has immunomodulatory actions on host immune cells where it displays an antiproliferative effect on T cells by inducing cell cycle arrest and also works with other H.pylori virulence factors to skew dendritic cells towards a tolerogenic phenotype,possibly contributing to the persistence of the pathogen in the gastric mucosa. | Samantha Shi Min Ling Khay Guan Yeoh Bow Ho | 2013 | World Journal of Gastroenterology2013，19，45： | 10 |
| 3 | 微创入路在脊柱手术中的应用显示文摘微创入路脊柱手术(MASS)是在经典微创脊柱手术(MISS)基础上发展而来的新的微创脊柱外科技术。MASS通过应用一些特殊设备或器械,经微创手术入路在直视下完成脊柱手术,减少手术入路对周围组织的损伤,同时又能达到传统开放手术同样的手术效果。MASS有效结合了MISS与开放手术的优势,减少了传统开放手术和MISS手术的并发症,具有手术组织创伤小、学习曲线相对MISS缩短、疗效确切、术后恢复快、医疗效价比高等优点,临床应用日益广泛。 | 宁尚龙 徐宝山 夏群 Khai S Lam | 2008 | 上海交通大学学报(医学版)2008，28，12： | 8 |
| 4 | 基于mtCOI基因序列的我国云南省和缅甸、柬埔寨草地贪夜蛾种群遗传多样性分析显示文摘为制定有效的草地贪夜蛾防控措施,分别自缅甸、柬埔寨和我国云南省采集4、2和8个种群共542个草地贪夜蛾样品,基于mtCOI基因序列分析这14个种群的遗传多样性指数、遗传分化系数及基因流。结果表明,缅甸草地贪夜蛾种群的单倍型多样性指数和平均核苷酸差异数分别介于0.273~0.396和4.643~6.727之间,高于我国云南省的草地贪夜蛾种群,分别介于0.047~0.214和0.791~3.636之间;除ZT种群、LS种群和TO种群外,其它11个种群的Fu’s F均为显著正值,表明缅甸、柬埔寨和我国云南省的草地贪夜蛾种群未经历种群扩张事件;在14个种群中,LS种群与其它种群分化较明显,TK种群、MY种群、CP种群、MS种群和KY种群有效迁入个数和有效迁出个数之和较高,分别为699.41、682.50、855.76、684.56和701.31,推测这5个种群在草地贪夜蛾基因交流中起着类似'中转站'的作用。 | 李向永 尹艳琼 KHIN Thein Nyunt KHAY Sathya 刘莹 谌爱东 | 2020 | 植物保护学报2020，47，4： | 5 |
| 5 | Re-Os isotopic data for molybdenum from Hejiangkou tungsten and tin polymetallic deposit in Chenzhou and its geological significance显示文摘Hejiangkou W-Sn-polymetallic deposit is a newly found deposit in Xitian ore field,one of the important and large scale W-Sn-polymetallic ore fields in the middle segment of Nanling metallogenic zone.Re-Os isotope dating was used on three molybdenite samples from Hejiangkou deposit to determine the ore forming period.The result is(224.9±2.6)Ma-(225±3.1)Ma and isochron age is(225.5±3.6)Ma.The field geological observations,geochronological data and optical petrography indicated that Hejiangkou deposit underwent multi-period of superimposed mineralization.It can be differentiated into three periods composed of six mineralization stages.The first period is the initial period for hydrothermal metasomatism and metal element enrichment during Indosinian Epoch.Further enrichment,strong brittle fracturing and hydrothermal metasomatism,remobilization and superimposition happened in the second period,during early Yanshanian.It is the major mineralization period of Hejiangkou deposit and can be subdivided into four mineralization stages,namely the skarn stage,oxide stage,high-temperature sulfide stage and low-temperature sulfide stage.And the third period is the mineralization period of a porphyry-skarn system related to the emplacement of the granite porphyry dyke.As minerogenic epoch of Hejiangkou deposit is similar with Hehuaping deposit,they show the possibility of Indosinian mineralization event in Nanling metallogenic zone.It can be an important perspective in any future mineral exploration in the same metallogenic zone. | 刘德波 杨柳 邓湘伟 戴雪玲 王雄军 CHONG khai yuen 杜高峰 魏和平 | 2016 | Journal of Central South University2016，23，5： | 5 |
| 6 | 中孔TUD负载的氧化铬掺杂氧化钛光催化降解苯酚(英文)显示文摘中孔的TUD-1负载的氧化铬掺杂TiO_2(Cr-TiO_2)有望用于紫外光照射下光催化降解苯酚的催化剂.低角X射线衍射和红外结果证实该样品中TUD-1存在无定形和中孔硅酸盐框架.TUD-1的中孔结构进一步得到N_2吸附-脱附的证实:为IV型等温线,并具有窄的孔径分布(3.9 nm)和高的比表面积(>490 m^2/g).透射电镜结果表明,所制样品保持了纳米颗粒和多孔孔道结构.TUD-1中负载Cr-TiO_2后使得带隙能量增加.与未负载的Cr-TiO_2相比,所有TUD-1负载的Cr-TiO_2光催化剂表现出更高的紫外光下降解苯酚的活性.其中Si/Ti摩尔比为30的Cr-TiO_2/TUD-1样品的光催化活性最高(82%).苯酚的光催化降解遵循一级Langmuir吸附等温线. | Yee Khai Ooi Leny Yuliati Siew Ling Lee | 2016 | Chinese Journal of Catalysis2016，37，11： | 4 |
| 7 | 新疆东天山金滩金矿区安山岩岩石学、地球化学及地质意义显示文摘新疆金滩金矿发育一套与成矿密切相关的安山岩,对该安山岩元素质量分数和相关性进行分析。研究结果表明:安山岩中锆石结构以及Th和U的质量分数之比ω(Th)/ω(U)(0.30~1.02)均显示其为岩浆成因,锆石LA-ICP-MS U-Pb年龄为(303.65±4.8)Ma,代表安山岩形成时代;安山岩ω(Si O_2)为54.29%~69.05%,ω(Al_2O_3)为11.27%~19.46%,全碱ω(K_2O+Na_2O)为2.46%~6.81%,ω(Mg O)为3.60%~10.45%,Mg指数为46~66。安山岩轻稀土元素(LREE)富集、轻重稀土元素分异作用明显,绝大多数样品具中等Eu负异常(δω(Eu)=0.44~0.77)和轻微Ce负异常(δω(Ce)=0.93~0.98),富集K,Rb,Ba,Th和U等大离子亲石元素,相对亏损Nb和Ti等高场强元素;岩浆经历了分离结晶作用,且发生部分熔融;安山岩可能是康古尔塔格洋向南俯冲,洋壳脱水进入地幔楔,被俯冲流体交代的地幔楔部分熔融,同时产生结晶分异作用而形成,而且遭受明显的陆壳物质混染;东天山地区在晚石炭世依旧存在康古尔洋的俯冲消减作用。 | 朱余银 王天国 黄超文 戴塔根 杨柳 CHONG Khai Yuen 杜高峰 | 2017 | 中南大学学报(自然科学版)2017，48，10： | 3 |
| 8 | 流通业与三次产业结构的关联及优化效应——基于灰色关联模型的再检验显示文摘本文在客观分析流通业引导资源配置和结构调整的功能、流通业自身发展促进产业结构优化、流通业促进技术创新带动产业结构优化调整等方面作用的基础上,引入熵值分析方法并应用灰色关联模型,明确流通业的产业结构优化效应。通过理论和实证分析,本文得出结论如下:首先,我国流通业发展对产业结构优化具有一定的积极作用,其不仅可促进经济增长,同时也可带动产业生产水平提高。流通业与三次产业间的灰色关联度较高,其与第一产业间的关联度达到0.6500;与第二产业间的关联度达到0.6301,与第三产业间的关联度则更高。总体而言流通业发展水平每提升1%就能提升产业结构优化比例0.023%。 | 赵莉 KHAW KHAI WAH | 2021 | 商业经济研究2021，，10： | 3 |
| 9 | Helicobacter pylori γ-Glutamyl Transpeptidase Is a Pathogenic Factor in the Development of Peptic Ulcer Disease显示文摘 | Min Gong Samantha Shi Min Ling Sook Yin Lui Khay Guan Yeoh Bow Ho | 2010 | Gastroenterology2010，，2： | 3 |
| 10 | Identification of Molecular Subtypes of Gastric Cancer with Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil显示文摘 | Zhengdeng Lei Iain Beehuat Tan Kakoli Das Niantao Deng Hermioni Zouridis Sharon Pattison Clarinda Chua Zhu Feng Yeoh Khay Guan Chia Huey Ooi Tatiana Ivanova Shenli Zhang Minghui Lee Jeanie Wu Anna Ngo Sravanthy Manesh Elisabeth Tan Bin Tean Teh Jimmy Bok | 2013 | Gastroenterology2013，，： | 2 |
| 11 | Coexistence of Helicobacter pylori spiral and coccoid forms in experimental mice显示文摘AbstractAIMToinfectmicewithHelicobacterpylorianddetectimmuneresponseagainsttwoformsofH.pylori.METHODSAnisolateofH.pyloriobtai... | HUA Jiesong 1, HO Bow 1, ZHENG Pengyuan 1, YEOH Khay Guan 2, NG Han Chong 1 and LIM Seng Gee 2 | 1998 | World Journal of Gastroenterology1998，4，6： | 2 |
| 12 | 传播与共融——中国文化对丝绸之路沿线装饰艺术的影响显示文摘在东西方交流的千年历史中,伴随着丝绸之路上人们的旅行和贸易往来,传统文化和意识形态的交流为中国文化向中东装饰艺术的传播做作出了巨大贡献,特别是在国际贸易活动中与中国有着密切联系的波斯古代帝国、西亚地区和阿拉伯半岛。从世界几大著名博物馆收藏的中东文物中选取7至17世纪装饰纺织品、陶器、金属制品和玻璃器皿的典型物品,对其配色方案和图案设计进行了研究,分析了中国文化对丝绸之路上装饰艺术的影响。通过研究发现,中国的文化思想、工艺技术、装饰风格对中东装饰艺术的色彩风格和图案设计产生了重要影响,丝绸之路在地区间文化与艺术的互动与交流中发挥了重要作用。 | Do Khai Ly 苏淼 杨媛媛 | 2022 | 东华大学学报(社会科学版)2022，22，2： | 2 |
| 13 | Meta-analysis of genetic polymorphisms and gastric cancer risk: Variability in associations according to race显示文摘 | Marie Loh King Xin Koh Boon Huat Yeo Chun Meng Song Kee Seng Chia Feng Zhu Khay Guan Yeoh Jeffrey Hill Barry Iacopetta Richie Soong | 2009 | European Journal of Cancer2009，，14： | 2 |
| 14 | Dynamics of Policy-Making in Malaysia:The Formulation of the New Economic Policy and the National Development Policy显示文摘 | Ho Khai Leong | 1992 | Asian Journal of Public Administration1992，，14： | 1 |
| 15 | Sinonasal clear cell adenocarcinoma: a case report显示文摘 | NEGAHBAN S DANESHBOD Y KHAI)EMI B | 2009 | Acta Cytol2009，53，： | 1 |
| 16 | Determination of cobalt and nickel in water samples by flame atomic absorption spectrometry after cloud point extraction显示文摘 | Jianrong Chen and Khay Chuan Teo | 2001 | Anal Chim Acta2001，，434： | 1 |
| 17 | Multilevel Dynamic Voltage Restorer显示文摘 | Poh Chiang Loh Vilathgamuwa D M Seng Khai Tang | 2004 | IEEE Power Electronics Letters2004，2，4： | 1 |
| 18 | Determination of cobalt and nickel in water samples by flame atomic absorption spectrometry after cloud point extraction显示文摘 | CHEN Jian-rong KHAY C T | 2001 | Anal Chim Acta2001，434，： | 1 |
| 19 | Determination of cobalt and nickel in water samples by flame atomic absorption spectrometry after cloud point extraction显示文摘 | Chen JR Khay CT | 2001 | Anal Chim Acta2001，434，： | 1 |
| 20 | Pulse oximeter as a home assessment tool:Knowledge and user experience among the community in Malaysia during the COVID-19 pandemic显示文摘Objective:To determine the degree of knowledge in the usage of pulse oximeter as a home assessment tool among the community in Malaysia.Methods:A cross-sectional survey was conducted in November 2021.The questionnaire assessed the knowledge in using pulse oximeters,user experience and opinions in using pulse oximeter as a home assessment tool during the pandemic.Results:A total of 504 respondents were included in the study,and the mean score in knowledge related to application of pulse oximetry was 73.00%,while the mean score in knowledge related to factors affecting pulse oximetry readings was only 38.51%.A total of 90.5% of the respondents recognised normal pulse rate and 88.5% knew the blood oxygen saturation levels of a healthy adult,while 69.4% recognised the definition of silent hypoxia.In addition,the majority of the respondents agreed that factors such as poor blood circulation(71.2%),excessive movements(69.8%),and hand position(60.7%)affected oximetry readings.However,61.7%,81.7%,77.2% and 76.8% of the respondents could not identify nail polish,skin colour,skin thickness and tattoos as factors that may affect oximetry readings respectively.Conclusions:The respondents showed a satisfactory level of knowledge related to application of pulse oximetry,but a poor level of knowledge related to factors affecting pulse oximetry readings among the community in Malaysia.Continuous efforts in educating the community on the correct use of pulse oximeters are crucial for appropriate home assessment and avoiding unnecessary stress. | Siew-Keah Lee Jin Wei Ma Khai Ying Chan Yi Song Cheong Wan Ting Hong Regine Chew Yi Ong Wei Cheng Tay Ang-Lim Chua | 2022 | Asian Pacific Journal of Tropical Medicine2022，15，5： | 1 |
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