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| 1 | Aggressive blood pressure treatment of hypertensive intracerebral hemorrhage may lead to global cerebral hypoperfusion:Case report and imaging perspective显示文摘Hypoperfusion injury related to blood pressure decrease in acute hypertensive intracerebral hemorrhage continues to be a controversial topic. Aggressive treatment is provided with the intent to stop the ongoing bleeding. However, there may be additional factors, including autoregulation and increased intracranial pressure, that may limit this approach. We present here a case of acute hypertensive intracerebral hemorrhage, in which aggressive blood pressure management to levels within the normal range led to global cerebral ischemia within multiple border zones. Global cerebral ischemia may be of concern in the management of hypertensive hemorrhage in the presence of premorbid poorly controlled blood pressure and increased intracranial pressure. | Jose Gavito-Higuera Rakesh Khatri Ihtesham A Qureshi Alberto Maud Gustavo J Rodriguez | 2017 | World Journal of Radiology2017，9，12： | 49 |
| 2 | An-tithrombotic and thrombolytic therapy for ischemic stroke: An-tithrombotic Therapy and Prevention of Thrombosis, 9th ed: Amer-ican College of Chest Physicians Evidence - Based Clinical Prac-tice Guidelines 显示文摘 | LANSBERG M G O'DONNELL M J KHATRI P | 2012 | Chest2012，141，2： | 1 |
| 3 | Extending the frontiers of surgical therapy for hepatic colorectal metastases: is there a limit? 显示文摘 | Khatri VP Petrelli N J Belghiti J | 2005 | J Clin Oncol2005，23，： | 1 |
| 4 | It is rocket science - why dietary nitrate is hard to Beet! part II: further mechanisms and therapeutic potential of the nitrate-nitrite-NO pathway 显示文摘 | Mills CE Khatri J Maskell P | 2016 | Br J Clin Pharmacol2016，，： | 1 |
| 5 | Swine influenza H1N1 virus induces acute inflammato- ry immune responses in pig lungs: a potential animal model for human H1N1 influenza virus显示文摘 | Khatri M Dwivedi V Krakowka S Manickam C Ali A Wang L Qin Z Renukaradhya G J Lee C W | 2010 | J Virol2010，84，11： | 1 |
| 6 | PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2显示文摘 | Perez J L Khatri L Chang C | 2001 | J Neurosci2001，21，15： | 1 |
| 7 | Staging and prognsis of colon cancer显示文摘 | Kehoe J Khatri VP | 2006 | Surg Oncol Clin N Am2006，15，： | 1 |
| 8 | Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis显示文摘BACKGROUND Septic arthritis is an orthopedic emergency requiring immediate surgical intervention.Current diagnostic standard of care is an invasive joint aspiration.Aspirations provide information about the inflammatory cells in the sample within a few hours,but there is often ambiguity about whether the source is infectious(e.g.bacterial)or non-infectious(e.g.gout).Cultures can take days to result,so decisions about surgery are often made with incomplete data.Novel diagnostics are thus needed.The“Sepsis MetaScore”(SMS)is an 11-mRNA host immune blood signature that can distinguish between infectious and noninfectious acute inflammation.It has been validated in multiple cohorts across heterogeneous clinical settings.AIM To study whether the SMS holds diagnostic validity in determining the etiology of acute arthritis.METHODS We conducted a blinded,prospective,non-interventional clinical study of the SMS.All patients undergoing work-up for a septic primary joint were enrolled.Patients proceeded through the normal standard-of-care pathway,including joint aspiration and inflammatory labs[white blood cell(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)].Venous blood was also drawn into PAX gene RNA-stabilizing tubes and mRNAs were measured using Nano String nCounter?.SMS was calculated blinded to clinical results.RESULTS A total of 20 samples were included,of which 11 were infected based on aspiration or intra-operative cultures.The SMS had an area under the ROC curve(AUROC)of 0.87 for separating infectious from non-infectious conditions.For comparison,the AUROCs for ESR=0.58,CRP=0.6,and WBC=0.59.At 100%sensitivity for infection,the specificity of the SMS was 40%,meaning nearly half of non-septic patients could have been ruled out for further intervention.CONCLUSION In this pilot study,SMS showed a high level of diagnostic accuracy in predicting septic joints compared to other diagnostic biomarkers.This quick blood test could be an important tool for early,accurate identification of acute septic joints and need for emergent surgery,improving clinical care and healthcare spending. | Blake J Schultz Timothy Sweeney Malcolm R DeBaun Melissa Remmel Uros Midic Purvesh Khatri Michael J Gardner | 2019 | World Journal of Orthopedics2019，10，12： | 1 |
| 9 | Stenting for coronary artery spasm显示文摘 | Khatri S Webb J G Carere R G | 2002 | Catheter Cardiovasc Interv2002，56，1： | 1 |
| 10 | Matrix metalloproteinases in vascular remodeling and atherogenesis-the good,the bad,and the ugly显示文摘 | Galis Z Khatri J | 2002 | Circ Res2002，90，： | 1 |
| 11 | Dermatofibrosarcoma protuberans:reappraisal of wide local excision and impact of inadequate initial treatment显示文摘 | Khatri V P Galante J M Bold R J | 2003 | Ann Surg Oncol2003，10，9： | 1 |
| 12 | Recommendations on angiographic revascularization grading standards for acute isehemic stroke: a consensus statement显示文摘 | Zaidat OO Yoo A J Khatri P | 2013 | Stroke2013，44，9： | 1 |
| 13 | Formation of TiC in-situ processedcomposites via solid-gas,solid-liquid and liquid-gas reaction inmolten Al-Ti显示文摘 | Khatri S H Koczak J M | 1993 | Materials Science and Engineering1993，162，12： | 1 |
| 14 | Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad and the ugly显示文摘 | Gails Z S Khatri J J | 2002 | Circ Res2002，90，： | 1 |
| 15 | Creep and microstructural stability of dispersion strengthened AlFe-V-Si alloy显示文摘 | Khatri S C Lawley A Koczak M J | 1993 | Mater Sci Eng A1993，167，： | 1 |
| 16 | Infection and acti-vation of bursal macrophages by virulent infectious bursal dis-ease virus显示文摘 | Khatri M Palmquist J M Cha R M | 2005 | Virus Res2005，113，1： | 1 |
| 17 | Susceptibility of chicken mesenchymal stem cells to infectious bursal disease virus 显示文摘 | KHATRI M SHARMA J M | 2009 | J Virol Methods2009，160，12： | 1 |
| 18 | Staging and prognosis of colon cancer显示文摘 | Kehoe J Khatri VP | 2006 | Surg Oneol Clin N Am2006，15，1： | 1 |
| 19 | Brain magnetic resonance imaging in adults with asthma 显示文摘 | Parker J Wolansky LJ Khatry D | 2011 | Contemp Clin Trials2011，32，1： | 1 |
| 20 | Matris metalloproteinases in vascular remaleling and atherogenesis:the good,the bad and the ugly显示文摘 | Galis Z S Khatri J J | 2002 | Circ Res2002，90，3： | 1 |
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