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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | 由磁共振成像评估的主动脉弓脉搏波传导速度是心血管事件的预测因子:多种族动脉粥样硬化研究显示文摘通过磁共振成像评估的主动脉弓脉搏波传导速度(pulse wave velocity,PWV)对心血管病事件的预测价值尚未完全确定。为了评估多种族动脉粥样硬化研究(multi-ethnic study of atherosclerosis,MESA)受试者中主动脉弓PWV与心血管病的关系,Ohyama等纳入3527例MESA受试者[基线时平均年龄为(62±10)岁,47%为男性], | 刘莉 叶鹏 Ohyama Y Ambale-Venkatesh B Noda C Kim JY Tanami Y Teixido-Tura G Chugh AR Redheuil A Liu CY Wu CO Hundley WG Bluemke DA Guallar E Lima JAC | 2017 | 中华高血压杂志2017，25，8： | 2 |
| 3 | Digital Bispectral analysis and its applications to nonlinear wave interactions显示文摘 | Y C Kim E J Powers | 1979 | IEEE Trans Plasma Sci1979，，7： | 2 |
| 4 | Moudgil,Regulation of autoimmune arthritis by the pro-inflammatory cytokine interferon-γ 显示文摘 | Kim E Y Chi H H Bouziane M | 2008 | Clin Immunol2008，127，： | 1 |
| 5 | Field experiments on mitigation of harmful algal blooms using a Sophorolipid-Yellow clay mixture and effects on marine plankton 显示文摘 | LEE Y J CHOI J K KIM E K | 2008 | Harmful Algae2008，7，： | 1 |
| 6 | Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells显示文摘 | KANG G Y LEE E R KIM J H | 2009 | Eur J Pharmacol2009，611，13： | 1 |
| 7 | Gas-phase dehydration of glycerol over ZSM-5 catalysts显示文摘 | KIM Y T JUNG K D PARK E D | 2010 | Microporous and Mesoporous Materials2010，131，13： | 1 |
| 8 | Antioxidant effect of natural plant extracts on the microencapsulated high oleic sunflower oil显示文摘 | AHN J H KIM Y P SEO E M | 2008 | Journal of Food Engineering2008，84，2： | 1 |
| 9 | Corticosteroid inhibits IL-4singaling through down-regulation of IL-4 receptor and STAT6 activity显示文摘 | SO E Y KIM S H PARK H H | 2002 | FEBS Letters2002，518，： | 1 |
| 10 | Overexpress cyclooxygenase2 is associated with a poor prognosis in patients with squamous cell carcinoma of the treated with radiation and concurrent chemotherapy显示文摘 | Kim Y B Kim G E Cho N H | 2002 | Cancer2002，95，： | 1 |
| 11 | Vertical array growth of small diameter single-walled carbon nanotubes显示文摘 | Xu Y Q Flor E Kim J M | 2006 | Journal of the American Chemical Society2006，128，： | 1 |
| 12 | Regulation of ILlheta-mediated MUC2 gene in NCI-H292 human airway epithelial cells显示文摘 | Kim Y D Kwon E J Raque G H | 2000 | Biochem Biophys Res Commum2000，274，5： | 1 |
| 13 | Oxidation behavior of titanium boride at elevated temperatures显示文摘 | KOH Y H LEE S Y KIM H E | 2001 | J Am Ceram Soc2001，84，1： | 1 |
| 14 | Recognition of machining features for cast the machined parts显示文摘 | Kim Y S Wang E | 2002 | Computer-Aided Design2002，34，1： | 1 |
| 15 | A lite- rature review of the epidemiology and treatment of acute gout显示文摘 | KIM K Y RALPH S H HUNSCHE E | 2003 | Clin Ther2003，25，6： | 1 |
| 16 | Piperine inhibition of 1-methyl4- phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells显示文摘 | Lee C S Han E S Kim Y K | 2006 | Eur J Pharmaco12006，537，13： | 1 |
| 17 | Properties of carbon coated ultra-thin film using taguchi experimental design显示文摘 | AHN J Y KIM D E CHOI J Y | 2003 | Journal of KSPE2003，20，4： | 1 |
| 18 | A compartmental model for the bicoid gradient显示文摘 | Kavousanakis M E Kanodia J S Kim Y Kevrekidis I G Shvartsman S Y | | 0，，01： | 1 |
| 19 | 查看详情显示文摘 | Gohil P Evans T E Ferron J R Moyer R A Petty C C Burrell K H Casper T A Garofalo A M Hyatt A W Jayakumar R J Kessel C Kim J Y La Haye R J Lohr J Luce T C Makowski M A Mazon D Menard J Murakami M Politzer P A Prater R Wade M R | | 0，，： | 1 |
| 20 | 查看详情显示文摘 | (e) Kim D C Lee Y R Yang B -S Shin K J Kim D J Chung B Y Yoo K H | | 0，，： | 1 |
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