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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Successful orthotopic liver transplanation forl amivudine-associated YMDD mutant hepatitis B virus显示文摘 | SAAB S KIM M WRIGHT T L | 2000 | Gastroenterology2000，119，5： | 2 |
| 3 | A novel transcription factor, T- bet, directs Thl lineage commitement显示文摘 | SZABO S J KIM S T COSTA G L | 2000 | Cell2000，100，6： | 1 |
| 4 | Estimating Corn Leaf Chlorophyll Concentration from Leaf and Canopy Reflectance 显示文摘 | Daughtry C S T Wahhall C L Kim M S | 2000 | Remote Sensing of Environment2000，74，2： | 1 |
| 5 | Estimating corn leaf chlorophyll concentration from leaf and canopy reflectanc显示文摘 | Daughtry C S T Walthall C L Kim M S | 2000 | Remote Sens Environ2000，74，： | 1 |
| 6 | Mechanical characteristics of light-weighted soils using dredged materials显示文摘 | YOONZ G L JEON S S KIM B T | 2004 | Marine Georesourees and Geotechnology2004，22，4： | 1 |
| 7 | Estimating corn fo-liar chlorophyll content from leaf and canopy ee-flectance显示文摘 | DAUGHTRY C S T WALTHALL C L KIM M S | 2000 | RemoteSensing of Environment2000，74，： | 1 |
| 8 | Financial market mod-els with levy process and time-varying volatility 显示文摘 | Kim Y S Rachev S T Bianchi M L | 2008 | Journal of Banking & Finance2008，32，7： | 1 |
| 9 | Unraveling nanotubes:field emission from an atomic wire显示文摘 | Rinzler A G Hafner J H Nikolaev P Nordlander P Colbert D T Smalley R E Lou L Kim S G Tomanek D | | 0，，5230： | 1 |
| 10 | Estimating corn leaf chlorophyll concentration from leaf and canopy reflectance显示文摘 | Daughtry C S T Wahhall C L Kim M S et a1 | 2000 | Remote Sensing of Environment2000，74，2： | 1 |
| 11 | Immunogenicity of an adenoviral- based middle east respiratory syndrome coronavirus vaccine in balb/c mice显示文摘 | Kim E Okada K Kenniston T Raj V S A1Hajri M M Farag E A AIHairi F Osterhaus A D Haagmans B L Gambotto A | 2014 | Vaccine2014，32，45： | 1 |
| 12 | CD36/fatty acid translocase, an inflammatory mediator, is involved in hyperlipidemia-induced exacerbation in ischemic brain injury显示文摘 | Kim E Tolhurst A T Qin L Y | 2008 | J Neurosci2008，28，18： | 1 |
| 13 | A family of novel basic leucine zipper proteins binds to seed-specification elements in the carrot Dc3 gene promoter 显示文摘 | KIM S Y THOMAS T L KIM S Y | 1998 | Journal of Plant Physiology1998，152，6： | 1 |
| 14 | Robust estimation of Covariance and its application to portfolio optimization 显示文摘 | Huo L J Kim T H Kim Y M | 2012 | Finance Research Letters2012，9，： | 1 |
| 15 | Alveolar soft part sarco- ma metastasized to both the skull and the brain 显示文摘 | Shin T H Jung Y J Kim O L Kim M S | 2012 | J Korean Neu- rosurg Soc2012，52，1： | 1 |
| 16 | Controlled metallic nanopillars for low impedance biomedical electrode显示文摘 | GARDNER C J TRISNADI J KIM T K BRAMMER K REISS L CHEN L H J1N S | 2014 | Acta Biomaterialia2014，10，5： | 1 |
| 17 | Thermal conductivity of W-Cu composites at various temperatures 显示文摘 | Kim Y D Oh N L Oh S T | 2001 | Materials Letters2001，51，： | 1 |
| 18 | Sensilla of Carabus (Isiocarabus) fiduciaries saihutoicus Csiki 显示文摘 | KIM J L YAMASAKI T | 1996 | Int J Morphol & Embryol1996，25，： | 1 |
| 19 | Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-γ-dependent mechanism显示文摘 | Netea M G Azam T Lewis E C Joosten L A Wang M Langenberg D Meng X Chan E D Yoon D Y Ottenhoff T Kim S H and Dinarello C A | | 0，，08： | 1 |
| 20 | Bond strength prediction for reinforced concrete members with highly corroded reinforcing bars 显示文摘 | Chung L Kim J H J Yi S T | 2008 | Cement and Concrete Composites2008，30，7： | 1 |
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