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| 1 | Roux-en-Y versus BillrothⅠreconstruction after distal gastrectomy for gastric cancer:A meta-analysis显示文摘AIM:To conduct a meta-analysis to compare Rouxen-Y(R-Y) gastrojejunostomy with gastroduodenal Billroth Ⅰ(B-Ⅰ) anastomosis after distal gastrectomy(DG) for gastric cancer.METHODS:A literature search was performed to identify studies comparing R-Y with B-Ⅰ after DG for gastric cancer from January 1990 to November 2012 in Medline,Embase,Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in The Cochrane Library.Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed or random effects model.Operative outcomes such as operation time,intraoperative blood loss and postoperative outcomes such as anastomotic leakage and stricture,bile reflux,remnant gastritis,reflux esophagitis,dumping symptoms,delayed gastric emptying and hospital stay were the main outcomes assessed.Meta-analyses were performed using RevMan 5.0 software(Cochrane library).RESULTS:Four randomized controlled trials(RCTs) and 9 non-randomized observational clinical studies(OCS) involving 478 and 1402 patients respectively were included.Meta-analysis of RCTs revealed that R-Y reconstruction was associated with a reduced bile reflux(OR 0.04,95%CI:0.01,0.14;P < 0.00 001) and remnant gastritis(OR 0.43,95%CI:0.28,0.66;P = 0.0001),however needing a longer operation time(WMD 40.02,95%CI:13.93,66.11;P = 0.003).Metaanalysis of OCS also revealed R-Y reconstruction had a lower incidence of bile reflux(OR 0.21,95%CI:0.08,0.54;P = 0.001),remnant gastritis(OR 0.18,95%CI:0.11,0.29;P < 0.00 001) and reflux esophagitis(OR 0.48,95%CI:0.26,0.89;P = 0.02).However,this reconstruction method was found to be associated with a longer operation time(WMD 31.30,95%CI:12.99,49.60;P = 0.0008).CONCLUSION:This systematic review point towards some clinical advantages that are rendered by R-Y compared to B-Ⅰ reconstruction post DG.However there is a need for further adequately powered,welldesigned RCTs comparing the same. | Jun-Jie Xiong Kiran Altaf Muhammad A Javed Quentin M Nunes Wei Huang Gang Mai Chun-Lu Tan Rajarshi Mukherjee Robert Sutton Wei-Ming Hu Xu-Bao Liu | 2013 | World Journal of Gastroenterology2013，19，7： | 33 |
| 2 | Prediction of the severity of acute pancreatitis on admission by urinary trypsinogen activation peptide: A meta-analysis显示文摘AIM: To undertake a meta-analysis on the value of urinary trypsinogen activation peptide (uTAP) in predicting severity of acute pancreatitis on admission. METHODS: Major databases including Medline, Embase, Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in the Cochrane Library were searched to identify all relevant studies from January 1990 to January 2013. Pooled sensitivity, specificity and the diagnostic odds ratios (DORs) with 95%CI were calculated for each study and were compared to other systems/biomarkers if mentioned within the same study. Summary receiver-operating curves were conducted and the area under the curve (AUC) was evaluated. RESULTS: In total, six studies of uTAP with a cut-off value of 35 nmol/L were included in this meta-analysis. Overall, the pooled sensitivity and specificity of uTAP for predicting severity of acute pancreatitis, at time of admission, was 71% and 75%, respectively (AUC = 0.83, DOR = 8.67, 95%CI: 3.70-20.33). When uTAP was compared with plasma C-reactive protein, the pooled sensitivity, specificity, AUC and DOR were 0.64 vs 0.67, 0.77 vs 0.75, 0.82 vs 0.79 and 6.27 vs 6.32, respectively. Similarly, the pooled sensitivity, specificity, AUC and DOR of uTAPvs Acute Physiology and Chronic Health Evaluation Ⅱ within the first 48 h of admission were found to be 0.64 vs 0.69, 0.77 vs 0.61, 0.82 vs 0.73 and 6.27vs 4.61, respectively. CONCLUSION: uTAP has the potential to act as a stratification marker on admission for differentiating disease severity of acute pancreatitis. | Wei Huang Kiran Altaf Tao Jin Jun-Jie Xiong Li Wen Muhammad A Javed Marianne Johnstone Ping Xue Christopher M Halloran Qing Xia | 2013 | World Journal of Gastroenterology2013，19，28： | 7 |
| 3 | Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment显示文摘 | Rowena McBeath Dana M Pirone Celeste M Nelson Kiran Bhadriraju Christopher S Chen | 2004 | Developmental Cell2004，，4： | 2 |
| 4 | The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus 显示文摘 | Kiran M Arpak N Unsal E | 2005 | J Clin Periodontol2005，32，3： | 1 |
| 5 | The effect of improved periodontal health on m etabolic control in type 2 DM显示文摘 | KIRAN M | 2005 | Clin Periodontal2005，32，3： | 1 |
| 6 | Calculation of the tensile and flexural strength of disordered materials using fractional calculus显示文摘 | Alberto Carpinteri Pietro Cornetti Kiran M | 2004 | Chaos Solitons & Fractals2004，21，5： | 1 |
| 7 | The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus显示文摘 | Kiran M Arpak N Unsal E | 2005 | J Clin Periodontol2005，32，3： | 1 |
| 8 | Hotel development and tourism impacts in Mauritius: Hoteliers' perspectives on sustainable tourism显示文摘 | Girish P Kiran D R Mootoo M | 2010 | Development Southern Africa2010，27，5： | 1 |
| 9 | Ethanol production in solid substrate fermentation using thermotolerant yeasts 显示文摘 | Kiran Sree N Sridhar M Venkateswar Rao L Ashok Pandey | 1999 | Process Biochem1999，34，： | 1 |
| 10 | Effects on antioxidant status of liver following atrazine exposure and its at- tenuation by vitamin E显示文摘 | Singh M Sandhir R Kiran R | 2011 | Experimental and Toxico- logic Pathology2011，63，3： | 1 |
| 11 | Modeling of surface roughness and the role of debris in micro - EDM 显示文摘 | Krishna Kiran M P S Joshi Suhas S | 2007 | Journal of Manufacturing Science and Engineering2007，，129： | 1 |
| 12 | The clinical significance of an elevated postoperative glucose value in nondiabetic patients after colorectal surgery : evidence for the need for tight glucose con- trol? 显示文摘 | Kiran RP Turina M Hammel J | 2013 | Ann Surg2013，258，4： | 1 |
| 13 | Sevoflurane as a sole anaesthetic for thymectomy in myasthenia gravis显示文摘 | Kiran U Choudhury M Saxena N | 2000 | Acta Anaesthesiol Scand2000，44，3： | 1 |
| 14 | Discovery of a quorum-sensing inhibitor of drug-resistant Staphylococcal infections by structure-based virtual screening显示文摘 | KIRAN M D ADIKESAVAN N V CIRIONI O | 2008 | Mol Pharmcol2008，73，： | 1 |
| 15 | Calculation of tensile and flexural strength of disordered materials using fractional calculus显示文摘 | Alberto Carpinteri Pietro Cornetti Kiran M Kolwanker | 2004 | Chaos Solitons and Fractals2004，21，3： | 1 |
| 16 | Use of an aromatase inhibitor in patients with polycystic ovary syndrome:aprospective ranfo-mized trial显示文摘 | Bayar U Basaran M Kiran S | 2006 | Fertil Steril2006，86，5： | 1 |
| 17 | Fujita' s exponent for a semilinear wave equation with linear damping显示文摘 | Qafsaoui M | 2002 | Adv Nonlinear Stud2002，2，： | 1 |
| 18 | Plasma visfatin levels in pregnant women with normal glucose tolerance,gestational diabetes and pre-gestational diabetes mellitus显示文摘 | Coskun A Ozkaya M Kiran G | | 0，，09： | 1 |
| 19 | Arterial-to-end-tidal carbon dioxide tension difference in children with congenital heart disease显示文摘 | Choudhury M Kiran U Choudhary S K | 2006 | JCardiothoracVascAnesth2006，20，2： | 1 |
| 20 | Use of an aromatase inhibitor in patients with polycystic ovary syndrome: A prospective randomized trial 显示文摘 | Bayar U Basaran M Kiran S | 2006 | Fertil Steril2006，86，5： | 1 |
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