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| 1 | 稳定性冠心病患者脑型利钠肽N端片段(NT-proBNP)与心血管事件及死亡率的关系显示文摘背景:明确心血管事件高危人群对最佳实施一、二级预防措施非常重要。
目的:研究血浆脑型利钠肽N端片段(prohormone braintype natriuretic peptide,NT—proBNP)水平是否能独立于现有其他诊断性检查预测心血管事件和死亡。
设计、地点及参试者:HSS研究(Heart and Soul Study)于2000年-2002年入选987例来自加利福尼亚州的稳定性冠心病患者进行前瞻性队列研究,平均随访3.7年(范围,0.1—5.3年)。 | Kirsten Bibbins-Domingo Reena Gupta Beeya Na 纪璟峰(译) 赵秀丽(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 49 |
| 2 | High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells显示文摘AIM: To analyze the relevance of the microRNA miR-196a for colorectal oncogenesis. METHODS: The impact of miR-196a on the restriction targets HoxA7, HoxB8, HoxC8 and HoxD8 was analyzed by reverse transcription polymerase chain reaction (RT-PCR) after transient transfection of SW480 cancer cells. The miR-196a transcription profile in colorectal cancer samples, mucosa samples and diverse cancer cell lines was quantifi ed by RT-PCR. Transiently miR-196a-transfected colorectal cancer cells were used for diverse functional assays in vitro and for a xenograft lung metastasis model in vivo. RESULTS: HoxA7, HoxB8, HoxC8 and HoxD8 were restricted by miR-196a in a dose-dependent and gene-specific manner. High levels of miR-196a activated the AKT signaling pathway as indicated by increased phosphorylation of AKT. In addition, high levels of miR-196a promoted cancer cell detachment,migration, invasion and chemosensitivity towards platin derivatives but did not impact on proliferation or apoptosis. Furthermore, miR-196a increased the development of lung metastases in mice after tail vein injection. CONCLUSION: miR-196a exerts a pro-oncogenic influence in colorectal cancer. | Carl Christoph Schimanski Kirsten Frerichs Fareed Rahman Martin Berger Hauke Lang Peter R Galle Markus Moehler Ines Gockel | 2009 | World Journal of Gastroenterology2009，15，17： | 40 |
| 3 | 探索中的德国鲁尔区城市生态系统:实施战略显示文摘步入21世纪后,人们越来越意识到未来的城市应该是更加可持续的。为了使城市得到可持续发展,我们需要将现有的规划范式转变为以生态系统观念为导向。这种新范式应该考虑每个场所、产业以及城市和区域基础设施输入/输出之间的平衡。本文概述了生态规划理论的发展;并通过德国鲁尔区城市生态系统建设的实例,探讨了现在正在进行的各种创新举措,是如何运用于闭合回路循环系统、实施战略和地方21世纪议程,分析了创新项目在规划过程中的作用。 | Kirsten Jane Robinson 王洪辉 | 2003 | 国外城市规划2003，18，6： | 18 |
| 4 | How Chinese Financial Centers Integrate into Global Financial Center Networks:An Empirical Study Based on Overseas Expansion of Chinese Financial Service Firms显示文摘The increasing globalization of the Chinese economy has been enabled by both Chinese financial institutions operating globally as well as international firms operating within China. In geographical terms, this has been organized through a number of strategic cities serving as gateways for the exchange of financial functions, products and practices between China and the global economy. Drawing on location data of financial service firms in China listed on stock exchanges in Shenzhen, Shanghai and Hong Kong, this paper shows that Chinese financial firms are expanding globally and how Chinese financial centers are positioned and connected in the urban networks shaped by these financial service firms. It is found that Hong Kong, China, holds strategic positions in the integration of Chinese cities into global financial center networks, and that establishing a foothold in global financial centers such as New York and London has been a priority for Chinese financial institutions. The increasing capital flows directed by Chinese financial institutionssuggests a shifting global financial geography, with numerous Chinese cities playing increasingly important roles within global financial center networks. | PAN Fenghua HE Ziyun Thomas SIGLER Kirsten MARTINUS Ben DERUDDER | 2018 | Chinese Geographical Science2018，28，2： | 15 |
| 5 | MicroRNAs:Promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential显示文摘Gastric cancer(GC) is the fourth most common cancer worldwide and ranks second in global cancer mortality statistics. Perioperative chemotherapy plays an important role in the management and treatment of advanced stage disease. However,response to chemotherapy varies widely,with some patients presenting no or only minor response to treatment. Hence,chemotherapy resistance is a major clinical problem that impacts on outcome. Unfortunately,to date there are no reliable biomarkers available that predict response to chemotherapy before the start of the treatment,or that allow modification of chemotherapy resistance. MicroRNAs(miRNAs) could provide an answer to this problem. miRNAs are involved in the initiation and progression of a variety of cancer types,and there is evidence that miRNAs impact on resistance towards chemotherapeutic drugs as well. This current review aims to provide an overview about the potential clinical applicability of miRNAs as biomarkers for chemoresistance in GC.The authors focus in this context on the potential of miRNAs to predict sensitivity towards different chemotherapeutics,and on the potential of miRNAs to modulate sensitivity and resistance towards chemotherapy in GC. | Christiane Matuszcak Joerg Haier Richard Hummel Kirsten Lindner | 2014 | World Journal of Gastroenterology2014，20，38： | 11 |
| 6 | Gender gap in acute coronary heart disease:Myth or reality?显示文摘AIM: To investigate potential gender differences in the prevalence of cardiovascular risk factors, cardiovascular disease (CVD) management, and prognosis in acute coronary syndrome (ACS). METHODS: A systematic literature search was performed through Medline using pre-specified key words . An additional search was performed, focusing specifically on randomized controlled clinical trials in relation to therapeutic intervention and prognosis. In total, 92 relevant articles were found. RESULTS: Women with CVD tended to have more hypertension and diabetes at the time of presentation, whereas men were more likely to smoke. Coronary angiography and revascularization by percutaneous coronary intervention were performed more often in men. Women were at a greater risk of short-term mortality and complications after revascularization. Interestingly, women under 40 years presenting with ACS were athighest risk of cardiovascular death compared with men of the same age, irrespective of risk factors. This disadvantage disappeared in older age. The long-term mortality risk of ACS was similar in men and women, and even in favor of women. CONCLUSION: Mortality rates are higher among young women with ACS, but this difference tends to disappear with age, and long-term prognosis is even better among older women. | Mette Claassen Kirsten C Sybrandy Yolande E Appelman Folkert W Asselbergs | 2012 | World Journal of Cardiology2012，4，2： | 9 |
| 7 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 8 | Combined analysis of land cover change and NDVI trends in the Northern Eurasian grain belt显示文摘我们在场在联合 MODIS 的时间系列分析的北欧亚的谷物带的地区性的环境监视的一条途径使差别植被索引(NDVI ) 正常化在时期 2001-2008 和陆地盖子变化(LCC ) 上的数据 2001 和 2008 MODIS 全球陆地盖子的分析产品(MCD12Q1 ) 。NDVI 趋势越过谷物带与是压倒性地否定的统计上重要(p0.05 ) 仅仅盖住 1% 土地的积极趋势出现。LCC 被在三个班之间的转变统治;农田,草地,和混合农田 / 天赋植被马赛克。联合我们 NDVI 趋势和 LCC 的分析,我们在与一致与的谷物带的南部的范围发现了农业放弃(到草地的农田) 的一个模式统计上重要(p0.05 ) 否定 NDVI 趋势并且多半由地区性的干旱开车。在谷物带的北范围,我们向农业增强发现了一个相反的趋势;在这种情况中,从农田马赛克由 LCC 代表了到纯农田,并且也与联系了统计上重要(p0.05 ) 否定 NDVI 趋势。相对小的簇统计上重要(p0.05 ) 与放弃和局部性的农业增强显示出的两块局部性的陆地相应的积极 NDVI 趋势那项陆地使用决策不是越过这个区域的制服。在北欧亚的谷物带的陆地表面变化在社会主义陆地任期和农业市场的苏联后面的重组的东方欧洲,俄国,和以前的领土是陆地盖子陆地使用变化(LCLUC ) 的一个更大的模式的部分。这里,我们证明 LCC 和 NDVI 趋势的联合分析在北欧亚的谷物带提供 LCLUC 的复杂性的一幅更完全的图画,包含更宽广的气候的强迫,和更狭窄的人为的影响,与力量独自从任何一个分析被获得比[出版摘要] | Christopher K. WRIGHT Kirsten M. de BEURS Geoffrey M. HENEBRY | 2012 | Frontiers of Earth Science2012，6，2： | 8 |
| 9 | Genetic epidemiology of primary sclerosing cholangitis显示文摘The aetiology of primary sclerosing cholangitis (PSC) is not known. A more than 80-fold increased risk of PSC among first-degree relatives emphasizes the importance of genetic factors. Genetic associations within the human leukocyte antigen (HLA) complex on chromosome 6p21 were detected in PSC 25 years ago. Subsequent studies have substantiated beyond doubt that one or more genetic variants located within this genetic region are important. The true identities of these variants,however,remain to be identified. Several candidate genes at other chromosomal loci have also been investigated. However,according to strict criteria for what may be denominated a susceptibility gene in complex diseases,no such gene exists for PSC today. This review summarises present knowledge on the genetic susceptibility to PSC,as well as genetic associations with disease progression and clinical subsets of particular interest (inflammatory bowel disease and cholangiocarcinoma). | Tom H Karlsen Erik Schrumpf Kirsten Muri Boberg | 2007 | World Journal of Gastroenterology2007，13，41： | 7 |
| 10 | Autoantibodies in primary sclerosing cholangitis显示文摘The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients,but the specifi city of these antibodies is generally low,and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecifi c dysregulation of the immune system,but the literature in PSC points to the possible presence of specifi c antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC,with a particular emphasis on the prevalence,clinical relevance and possible pathogenetic importance of each individual marker. | Johannes Roksund Hov Kirsten Muri Boberg Tom H Karlsen | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 11 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 12 | WONCA研究论文摘要汇编——减少食盐对心血管疾病的预防作用显示文摘背景美国饮食含盐量高,多数为加工食品。减少食盐的摄入是公众健康的重要目标。方法本研究使用冠心病策略模式,将全人群食盐减少到3g/d(钠1200mg/d)潜在的获益进行量化。评价年龄、性别、种族亚组的心血管病发生率和成本,将减少食盐与其他减少心血管风险的干预方法进行对照;将减少食盐与高血压药物治疗做对照确定成本效应。结果每日减少食盐3g,预计可减少年度新发病例:冠心病6.0万~12.0万例、脑卒中3.2万~6.6万例、心肌梗死5.4万~9.9万例;且可使年度全因死亡患者数目减少4.4万~9.2万。任何人群均可获益,黑人获益比例最高。女性,尤其脑卒中、老年冠心病、年纪较轻者病死率下降明显。摄入盐减少的心血管益处与减少吸烟、肥胖和胆固醇水平所带来的益处相同。所设计的调整干预项可达到每日摄入盐减少3g,并可节省医疗成本100亿~240亿美元。即使在2010—2019年,此干预项逐渐达到每日适度减少食盐1g也能削减医疗成本,与高血压患者降压用药相比,更具有成本效应。结论适度减少食盐可减少心血管事件和医疗成本,应该成为维护公众健康的目标。 | Kirsten Bibbins-Domingo Glenn MChertow Pamela G Coxson 周淑新(译) | 2010 | 中国全科医学2010，13，32： | 5 |
| 13 | Carbon Dioxide and Nitrous Oxide Emissions from Naturally Occurring Sulfate-Based Saline Soils at Different Moisture Contents显示文摘Soil salinization may negatively affect microbial processes related to carbon dioxide(CO_2) and nitrous oxide(N_2O) emissions. A short-term laboratory incubation experiment was conducted to investigate the effects of soil electrical conductivity(EC) and moisture content on CO_2 and N_2O emissions from sulfate-based natural saline soils. Three separate 100-m long transects were established along the salinity gradient on a salt-affected agricultural field at Mooreton, North Dakota, USA. Surface soils were collected from four equally spaced sampling positions within each transect, at the depths of 0–15 and 15–30 cm. In the laboratory, artificial soil cores were formed combining soils from both the depths in each transect, and incubated at 60% and 90% water-filled pore space(WFPS) at 25?C. The measured depth-weighted EC of the saturated paste extract(EC_e) across the sampling positions ranged from 0.43 to 4.65 dS m^(-1). Potential nitrogen(N) mineralization rate and CO_2 emissions decreased with increasing soil EC_e, but the relative decline in soil CO_2 emissions with increasing ECe was smaller at 60% WFPS than at 90% WFPS. At 60% WFPS, soil N_2O emissions decreased from 133 μg N_2O-N kg^(-1) soil at EC_e < 0.50 dS m^(-1) to 72 μg N_2O-N kg^(-1) soil at EC_e = 4.65 dS m^(-1). In contrast, at 90% WFPS,soil N_2O emissions increased from 262 μg N_2O-N kg^(-1) soil at EC_e = 0.81 dS m^(-1) to 849 μg N_2O-N kg^(-1) soil at EC_e = 4.65 dS m^(-1), suggesting that N_2O emissions were linked to both soil ECe and moisture content. Therefore, spatial variability in soil EC_e and pattern of rainfall over the season need to be considered when up-scaling N_2O and CO_2 emissions from field to landscape scales. | Resham THAPA Amitava CHATTERJEE Abbey WICK Kirsten BUTCHER | 2017 | Pedosphere2017，27，5： | 5 |
| 14 | Randomized study comparing incidence of radial artery occlusion post-percutaneous coronary intervention between two conventional compression devices using a novel airinflation technique显示文摘AIM To compare post-percutaneous coronary intervention(PCI) radial artery occlusion(RAO) incidence between two conventional radial artery compression devices using a novel air-inflation technique.METHODS One hundred consecutive patients post-PCI were randomized 1:1 to Safeguard or TR band compression devices. Post-radial sheath removal, each compression device was inflated with additional 2 m L of air above index bleeding point during air-filled device application and gradually down-titrated accordingly. RAO was defined as absence of Doppler flow signal performed at 24 h and at 6 wk post-PCI. Patients with missing data were excluded. Statistical significance was defined as P < 0.05.RESULTS All patients had 6 F radial sheath inserted. No significant differences were observed between Safeguard Radial(n = 42) vs TR band(n = 42) in terms of age(63 ± 11 years vs 67 ± 11 years), clinical presentation(electives, n = 18 vs n = 16; acute coronary syndrome, n = 24 vs n = 26) and total procedural heparin(7778 ± 2704 IU vs 7825 ± 2450 IU). RAO incidence was not significantly different between groups at 24 h(2% vs 0%, P = 0.32) and 6 wk(0%, both).CONCLUSION Safeguard Radial and TR band did not demonstrate significant between-group differences in short-term RAO incidence. Lack of evidence of RAO in all postPCI patients at 6 wk follow-up, regardless of radial compression device indicate advantage of using the novel and pragmatic air-inflation technique. Further work is required to more accurately confirm these findings. | Victor Voon Muhammad Ayyaz Ul Haq Ciara Cahill Kirsten Mannix Catriona Ahern Terence Hennessy Samer Arnous Thomas Kiernan | 2017 | World Journal of Cardiology2017，9，11： | 5 |
| 15 | Liver Transplantation for Nonresectable Liver Metastases From Colorectal Cancer显示文摘 | Morten Hagness Aksel Foss P?l-Dag Line Tim Scholz P?l Foyn J?rgensen Bjarte Fosby Kirsten Muri Boberg ?ystein Mathisen Ivar P. Gladhaug Tor Skatvedt Egge Steinar Solberg John Hausken Svein Dueland | 2013 | Annals of Surgery2013，，5： | 4 |
| 16 | Modification of tubular chitosan-based peripheral nerve implants: applications for simple or more complex approaches显示文摘Surgical treatment of peripheral nerve injuries is still a major challenge in human clinic.Up to now,none of the well-developed microsurgical treatment options is able to guarantee a complete restoration of nerve function.This restriction is also effective for novel clinically approved artificial nerve guides.In this review,we compare surgical repair techniques primarily for digital nerve injuries reported with relatively high prevalence to be valuable attempts in clinical digital nerve repair and point out their advantages and shortcomings.We furthermore discuss the use of artificial nerve grafts with a focus on chitosan-based nerve guides,for which our own studies contributed to their approval for clinical use.In the second part of this review,very recent future perspectives for the enhancement of tubular(commonly hollow)nerve guides are discussed in terms of their clinical translatability and ability to form three-dimensional constructs that biomimick the natural nerve structure.This includes materials that have already shown their beneficial potential in in vivo studies like fibrous intraluminal guidance structures,hydrogels,growth factors,and approaches of cell transplantation.Additionally,we highlight upcoming future perspectives comprising co-application of stem cell secretome.From our overview,we conclude that already simple attempts are highly effective to increase the regeneration supporting properties of nerve guides in experimental studies.But for bringing nerve repair with bioartificial nerve grafts to the next level,e.g.repair of defects>3 cm in human patients,more complex intraluminal guidance structures such as innovatively manufactured hydrogels and likely supplementation of stem cells or their secretome for therapeutic purposes may represent promising future perspectives. | Nina Dietzmeyer Maria F?rthmann Claudia Grothe Kirsten Haastert-Talini | 2020 | Neural Regeneration Research2020，15，8： | 4 |
| 17 | Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue显示文摘 | Kirsten Muri Boberg Roger W. Chapman Gideon M. Hirschfield Ansgar W. Lohse Michael P. Manns Erik Schrumpf | 2010 | Journal of Hepatology2010，，2： | 4 |
| 18 | ERODIBILITY CRITERION FOR AUXILIARY SPILLWAYS OF DAMS显示文摘The ability to reliably design auxiliary spillways has become a pressing requirement because of the very large number of dams involved. An empirical classification index representing the erosional resistance of the overall range of particulate, jointed, and intact earth materials is presented and correlated for a number of practical cases from Arkansas and Kansas in the United States of America and from South Africa with the specific stream power of flows observed to be associated with various degrees of erosion. The United States Department of Agriculture data base and the format in which the dare were prepared for the purposes herein, are deseribed in detail. The modes of erosion that occur in spillways are defined.Guidelines are provided for evaluating the failure status of an erosion damaged spillway that enables determination of whether the incident specific stream power exceeded, equalled, or fell below the erosional resistance of various sections of the ground profile affected. The correlation function between specific stream power and erodibility index provides the required design criterion. | Hendrik A. D. Kirsten (Steffen, Robertson, and Kirsten, Ine., Box 55291 Northlands 2116, S. Africa)John S. Moore(Natural Resources Conservation Service, USDA, Box 2890, Washington, DC 20013)Louis H. Kirsten(Civil & Structural Engineering Dept., Iscor Mini | 2000 | International Journal of Sediment Research2000，15，1： | 4 |
| 19 | 等离子喷涂AP40生物活性玻璃陶瓷涂层的结构和性能显示文摘采用大气等离子喷涂技术,在TiAl6V4基体上制备了AP40玻璃陶瓷涂层.利用光学显微镜,SEM和XRD分析技术对涂层形貌、显微组织结构和相组成进行了研究.探讨了热处理工艺对涂层组织结构及其性能的影响,并按德国DIN 50160标准进行涂层的拉伸强度试验.结果表明:等离子喷涂AP40玻璃陶瓷涂层在喷涂态,只有较低的结晶度.喷涂工艺对涂层的孔隙率和粉末沉积率有较大的影响.合适的热处理工艺可提高涂层的结晶度,减少孔隙以及提高结合强度. | 贺定勇 赵力东 BOBZIN Kirsten LUGSCHEIDER Erich | 2006 | 无机材料学报2006，21，3： | 4 |
| 20 | nhe regulation and deregulation of Wnt signaling by PARK genes in health and disease显示文摘 | Daniel C. Berwick Kirsten Harvey | 2014 | Journal of Molecular Cell Biology2014，8，1： | 4 |
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