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| 1 | Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure显示文摘Acute hepatic failure due to hepatitis B virus(HBV)can occur both during primary infection as well as after reactivation of chronic infection.Guidelines recommend considering antiviral therapy in both situations,although evidence supporting this recommendation is weak.Since HBV is not directly cytopathic,the mechanism leading to fulminant hepatitis B is thought to be primarily immunemediated.Therefore,immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis B.Here wereport our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment,which resulted in a rapid improvement of clinical and liver parameters. | Jan-Hendrik Bockmann Maura Dandri Stefan Lüth Nadine Pannicke Ansgar W Lohse | 2015 | World Journal of Gastroenterology2015，21，7： | 13 |
| 2 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 3 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 4 | Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue显示文摘 | Kirsten Muri Boberg Roger W. Chapman Gideon M. Hirschfield Ansgar W. Lohse Michael P. Manns Erik Schrumpf | 2010 | Journal of Hepatology2010，，2： | 4 |
| 5 | Distribution and effects of tree leaf litter on vegetation composition and biomass in a forest–grassland ecotone显示文摘Aims After abandonment of grasslands,secondary succession leads to the invasion by woody species.This process begins with the accumulation of tree litter in the forest–grassland ecotone.Our objectives were to determine the relationships between litter amounts and vegetation composition and cover along natural forest–grassland ecotones and to experimentally study the initial effects of tree litter accumulation on grassland vegetation and on microsite conditions.Methods We established 11 transects varying from 12 to 15 m in length in different forest–grassland ecotones in the Lahn-Dill highlands,Germany,and measured the mass and cover of tree litter and the cover and composition of vegetation at five sequential positions along each transect by using 1 m2 plots with five replications.In a field experiment,we established plots subjected to different litter amounts(0,200 and 600g m^(−2))and evaluated changes in grassland vegetation,soil temperature and soil nutrient availability below the litter layer.Important Findings Tree litter amounts decrease from 650 to 65g m^(−2) across the forest–grassland ecotone.Vegetation changed from shrubs and annual species(adapted to more stressful conditions)in the forests edge to grasses,rosettes and hemirosette species(with higher competitive abilities)in the grassland.These anthropogenic forest–grassland ecotones showed abrupt edges,and the two adjacent ecosystems were characterized by different species pools and functional groups.In the field experiment,the presence of a litter layer reduced vegetation biomass and cover;the species richness was only reduced in the treatment with high litter(600g m^(−2)).Additionally,adding litter on top of vegetation also reduced thermal amplitude and the number of frost days,while increasing the availability of some nutrients,such as nitrogen and aluminium,the latter being an indicator of soil acidification.Adding a tree litter layer of 600g m^(−2) in grassland areas had strong effects on the composition and diversity of grassland vegetation by reducing the cover of several key grassland species.In,or near,forest edges,litter accumulation rapidly changes established vegetation,microsite conditions and soil nutrients. | Alejandro Loydi Kerstin Lohse Annette Otte Tobias W.Donath R.Lutz Eckstein | 2014 | Journal of Plant Ecology2014，7，3： | 3 |
| 6 | Exploiting Natural Variation in Tomato to Define Pathway Structure and Metabolic Regulation of Fruit Polyphenolics in the Lycopersicum Complex显示文摘While the structures of plant primary metabolic pathways are generally well defined and highly conserved across species,those defining specialized metabolism are less well characterized and more highly variable across species.In this study,we investigated polyphenolic metabolism in the lycopersicum complex by characterizing the underlying biosynthetic and decorative reactions that constitute the metabolic network of polyphenols across eight different species of tomato.For this purpose,GC-MS-and LC-MS-based metabolomics of different tissues of Solatium lycopersicum and wild tomato species were carried out,in concert with the evaluation of cross-hybridized microarray data for MapMan-based transcriptomic analysis,and publicly available RNA-sequencing data for annotation of biosynthetic genes.The combined data were used to compile species-specific metabolic networks of polyphenolic metabolism,allowing the establishment of an entire pan-species biosynthetic framework as well as annotation of the functions of decoration enzymes involved in the formation of metabolic diversity of the flavonoid pathway.The combined results are discussed in the context of the current understanding of tomato flavonol biosynthesis as well as a global view of metabolic shifts during fruit ripening.Our results provide an example as to how large-scale biology approaches can be used for the definition and refinement of large specialized metabolism pathways. | Takayuki Tohge Federico Scossa Regina Wendenburg Pierre Frasse llse Balbo Mutsumi Watanabe Saleh Alseekh Sagar Sudam Jadhav Jay C.Delfin Marc Lohse Patrick Giavalisco Bjoern Usadel Youjun Zhang Jie Luo Mondher Bouzayen Alisdair R.Fernie | 2020 | Molecular Plant2020，13，7： | 3 |
| 7 | Autoimmune hepatitis显示文摘 | Ansgar W. Lohse Giorgina Mieli-Vergani | 2010 | Journal of Hepatology2010，，1： | 3 |
| 8 | Every Minute Counts When the Renal Hilum Is Clamped During Partial Nephrectomy 显示文摘 | R. Houston Thompson Brian R. Lane Christine M. Lohse Bradley C. Leibovich Amr Fergany Igor Frank Inderbir S. Gill Michael L. Blute Steven C. Campbell | 2010 | European Urology2010，，： | 3 |
| 9 | Long-term Consequences of Postoperative Cognitive Dysfunction显示文摘 | Jacob Steinmetz Karl Bang Christensen Thomas Lund Nicolai Lohse Lars S. Rasmussen | 2009 | Anesthesiology2009，，3： | 3 |
| 10 | Unmet clinical need in autoimmune liver diseases显示文摘 | Jessica K. Dyson Gwilym Webb Gideon M. Hirschfield Ansgar Lohse Ulrich Beuers Keith Lindor David E.J. Jones | 2014 | Journal of Hepatology2014，，： | 2 |
| 11 | Hepatitis B Virus Limits Response of Human Hepatocytes to Interferon-α in Chimeric Mice显示文摘 | Marc Lütgehetmann Till Bornscheuer Tassilo Volz Lena Allweiss Jan–Hendrick Bockmann Joerg M. Pollok Ansgar W. Lohse Joerg Petersen Maura Dandri | 2011 | Gastroenterology2011，，7： | 2 |
| 12 | Association of autoimmune hepatitis and systemic lupus erythematodes:A case series and review of the literature显示文摘Liver test abnormalities have been described in up to 60% of patients with systemic lupus erythematodes(SLE) at some point during the course of their disease.Prior treatment with potentially hepatotoxic drugs or viral hepatitis is commonly considered to be the main cause of liver disease in SLE patients.However,in rare cases elevated liver enzymes may be due to concurrent autoimmune hepatitis(AIH).To distinguish whether the patient has primary liver disease with associated autoimmune clinical and laboratory features resembling SLE- such as AIH- or the elevation of liver enzymes is a manifestation of SLE remains a difficult challenge for the treating physician.Here,we present six female patients with complex autoimmune disorders and hepatitis.Patient charts were reviewed in order to investigate the complex relationship between SLE and AIH.All patients had coexisting autoimmune disease in their medical history.At the time of diagnosis of AIH,patients presented with arthralgia,abdominal complaints,cutaneous involvement and fatigue as common symptoms.All patients fulfilled the current diagnostic criteria of both,AIH and SLE.Remission of acute hepatitis was achieved in all cases after the initiation of immunosuppressive therapy.In addition to this case study a literature review was conducted. | Claudia Beisel Christina Weiler-Normann Andreas Teufel Ansgar W Lohse | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 13 | Presence of EpCAM‐positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma显示文摘 | Kornelius Schulze Christin Gasch Katharina Staufer Bj?rn Nashan Ansgar W. Lohse Klaus Pantel Sabine Riethdorf Henning Wege | 2013 | Cancer2013，，9： | 2 |
| 14 | Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients显示文摘AIM: To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. METHODS: Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen (ANA) and smooth muscle antigen (SMA) autoantibodies characterized type 1 AIH. Type 3 (AIH) was solely characterized by the occurrence of soluble liver antigen/liver-pancreas antigen (SLA/LP) autoantibodies either with or without ANA or SMA autoantibodies. RESULTS: Most prevalent HLAs were A2 (68 patients, 48%), B8 (63 patients, 44%), C7 (90 patients, 63%), DR3 (49 patients, 38%), DR4 (49 patients, 38%) and DQ2 (42 patients, 30%). Compared to the Italian and North American patients, we found fewer patients with a DQ2 subtype. Furthermore, the B8-DR3-DQ2 human leucocyte antigen (HLA) was also less prominent compared to the North American patients. However, prevalences of B8, DR3, DR4, DR7, DR11 and DR13 were comparable to the Italian and North American patients. Furthermore, we report on an additional subgroup of patients with SLA/LP positive AIH. Generally, in this subgroup of patients the same HLA subtypes were favoured as the AIH type 1. CONCLUSION: Although HLA subtypes were comparable between these three collectives, the German patients were distinct from the Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2HLA. A clinical correlation, e.g. difference in severity or treatability of AIH type 1, has yet to be determined. | Andreas Teufel Markus Wrns Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 15 | Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis显示文摘 | Johannes Hartl Hanno Ehlken Christina Weiler-Normann Marcial Sebode Benno Kreuels Nadine Pannicke Roman Zenouzi Claudia Glaubke Ansgar W. Lohse Christoph Schramm | 2014 | Journal of Hepatology2014，，： | 2 |
| 16 | Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status显示文摘 | Johannes Stallhofer Matthias Friedrich Astrid Konrad-Zerna Martin Wetzke Peter Lohse Jürgen Glas Cornelia Tillack-Schreiber Fabian Schnitzler Florian Beigel Stephan Brand | 2015 | Inflammatory Bowel Diseases2015，，10： | 2 |
| 17 | High expression levels of survivin protein independently predict a poor outcome for patients who undergo surgery for clear cell renal cell carcinoma显示文摘 | Parker AS Kosarik F Lohse Cmhouston | 2006 | Cancer2006，107，1： | 1 |
| 18 | Consumer Eye Movement Patterns on Yellkow Pages Advertising显示文摘 | Lohse G L | 1997 | Journal of Advertising1997，26，1： | 1 |
| 19 | Contralateral adrenal metastasis of renal cell carcinoma:treatment,outcome and a review显示文摘 | LAU WK ZINCKE H LOHSE CM | 2003 | BJU Int2003，91，9： | 1 |
| 20 | Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2 显示文摘 | Lorenz K Lohse M J Quitterer U | 2003 | Nature2003，426，6966： | 1 |
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