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| 1 | Human enamel thickness and ENAM polymorphism显示文摘The tooth enamel development gene, enamelin(ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism(SNP) C14625T(rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status,controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel.Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner(P = 0.040)when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure. | Diane M Daubert Joanna L Kelley Yuriy G Udod Carolina Habor Chris G Kleist Ilona K Furman Igor N Tikonov Willie J Swanson Frank A Roberts | 2016 | International Journal of Oral Science2016，8，2： | 2 |
| 2 | The Relation-ship of Drought Frequency and Duration To Time Scales显示文摘 | Mckee T B Doesken N J Kleist J | 1993 | California- Eighth Conference on Ap- plied Climatology1993，，： | 1 |
| 3 | Favourable effect of flunarizine on the recovery form hemiparesis in rats with intracerebral hematomas 显示文摘 | Kleist B van Reempts J van Deuren B | 1989 | Neurosci Lett1989，103，： | 1 |
| 4 | Aerobic epoxidation of olefins catalyzed by the cobalt-based metal-organic Framework STA-12(Co)显示文摘 | BEIER M J KLEIST W WHARMBY M T | 2012 | Chemistry-A European Journal2012，18，3： | 1 |
| 5 | Interferon gamma and Interleukin-2 secretion in whole blood cultures from small- cell lung cancer patients显示文摘 | Szopinski J yon Kleist S Rowinska-Zakrzewska E | 2001 | Tumour Biol2001，22，2： | 1 |
| 6 | Gastroinleslinal stromal tumor and gastric adenocarcinoma collision tumors显示文摘 | Kleist B Lasota J Miettinen M | 2010 | Hum Pathol2010，41，7： | 1 |
| 7 | Gastrointestinal stromal tumorand gastric adenocarcinoma collision tumors显示文摘 | Kleist B Lasota J Miettinen M | 2010 | Hum Pathol2010，41，7： | 1 |
| 8 | Failure optimization of geometrically linear/nonlinear laminated composite structures using a two-step hierarchical model adaptivity 显示文摘 | JOHANSEN L S LUND E KLEIST J | 2009 | Computer Methods in Applied Mechanics and Engineering2009，198，3032： | 1 |
| 9 | A large source of low- volatility secondary organic aerosol显示文摘 | EHN M THORNTON J KLEIST E | 2014 | Nature2014，506，7489： | 1 |
| 10 | The reiationship of drought frequency and duration to time scales显示文摘 | Mckee T B Doesken N J Kleist J | 1993 | Eighth Conference on Applied Climatology1993，，： | 1 |
| 11 | The relation of drought fre- quency and duration to time scales显示文摘 | Mckee T B Doesken N J Kleist J | 1993 | Proceedings of the Eighth Conference on Applied Climatology American Meteorological Society Boston1993，，： | 1 |
| 12 | A large source of low-volatility secondary organic aerosol 显示文摘 | Ehn M Thornton J A Kleist E eta/ | 2014 | Nature2014，506，7489： | 1 |
| 13 | The relationship of drought fre-quency and duration to time scales显示文摘 | MCKEE T B DOESKEN N J KLEIST J | 1993 | Proceedings of the Eighth Confer-ence on Applied Climatology1993，5，： | 1 |
| 14 | The relationship of drought frequency and duration to time scales 显示文摘 | McKee T B Doesken N J Kleist J | 1993 | Bos- ton MA: American Meteorological Society1993，17，22： | 1 |
| 15 | Noise pollution alters ecological services: enhanced pollination and disrupted seed dis- persal显示文摘 | Francis C D Kleist N J Ortega C P | 2012 | Proceedings of the Royal Society2012，279，： | 1 |
| 16 | A distributed storage sys-tem with dCache 显示文摘 | Behrmann G Fuhrmann P? Kleist J | 2008 | Journal of Physics: Conference Series2008，119，6： | 1 |
| 17 | The Relationship of Drought Frequency and Duration to Time Scales显示文摘 | MCKEE T B DOESKEN N J KLEIST J | 1993 | Eighth Conference on Applied Climatology1993，，： | 1 |
| 18 | Cerebral white matter disease in children may be caused by mitochondrial respiratory chain defi- ciency显示文摘 | de Lonlay Debeney P von Kleist Retzow J C Hertz-Pan- nier L | 2000 | J Pediatr2000，136，2： | 1 |
| 19 | Introduction of the GSI into the NCEP Global Data Assimilation System显示文摘 | Kleist D T Parrish D F Derber J C | 2009 | Weather and Forecasting2009，24，6： | 1 |
| 20 | The relationship of drought frequency and duration to time scales显示文摘 | McKee T B Doesken N J Kleist J | 1993 | Eighth Conf on Applied Climatology Anaheim CA Amer Meteor Soc1993，1993，1： | 1 |
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