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| 1 | Effect of serum γ-glutamyltranferase and albumin levels on the response to cardiac resynchronization therapy in the elderly显示文摘Background Several liver function tests have been identified as predictors of hospitalization for heart failure(HF) and death in patients with chronic HF. The relationship between serum γ-glutamyltranferase(GGT) and albumin(SA) levels with the response to cardiac resynchronization therapy(CRT) has not been reliably determined. The aim of the study was to evaluate the impact of liver function tests on the results of CRT in the elderly. Methods Baseline GGT and SA were assessed before CRT device implantation in the elderly(> 70-year-old) patients. The endpoints were:(1) CRT response defined as > 5% left ventricular ejection fraction improvement and no hospitalization for HF or cardiovascular death;(2) hospitalizations;and(3) mortality. Results Eighty of 138(58%) included patients were responders at nine months. Compared to responders, the SA levels were not significantly different(35.1 ± 5.4 vs. 33.6 ± 5.5 g/L, P = 0.103);but the GGT levels, higher(81.6 ± 69.3 vs. 54.7 ± 49.6 U/L, P = 0.013) in non-responders to CRT. GGT level was independently associated with non-response to CRT(P < 0.001, OR = 0.17;95% CI: 0.08–0.38, P < 0.001). GGT cut-off value ≥ 55 U/L was highly predictive of non-response [AUC = 0.65, 64% Sensitivity, 69% Specificity(95% CI: 0.56–0.74)]. GGT ≥ 55 U/L was also associated with higher risk of hospitalization for atrial fibrillation(AF)(95% vs. 83%, P = 0.024). Both SA and GGT had no impact on overall(P = 0.220, P = 0.723) mortality. Conclusions Higher level of GGT is an independent predictor of non-response to CRT in patients over age 70 years and is associated with higher risk of hospitalization for AF. Baseline serum levels of albumin and GGT and have no impact on mortality in elderly patients undergoing CRT. | Maciej Kubala Alexis Hermida Otilia Buiciuc Pierre-Marc Lallemand Geneviève Bertaina Frédéric Anselme Didier Klug Momar Diouf Jean-Sylvain Hermida | 2020 | Journal of Geriatric Cardiology2020，17，6： | 3 |
| 2 | Formation and Decomposition Mecha- nisms for Clathrate Hydrates 显示文摘 | Tse J S Klug D D | 2002 | J Supramolecular Chem2002，2，45： | 1 |
| 3 | Risk factors related to infections of implanted pacemakers and cardioverter-defibrillators: results of a large prospective study显示文摘 | Klug D Balde M Pavin D | 2007 | Circulation2007，116，： | 1 |
| 4 | Com- plications of permanent cardiac pacing 显示文摘 | Klug D Marqui6 C Laeroix D | 2003 | Arch Mal Coeur Vaiss2003，7，： | 1 |
| 5 | Repetitive zinc-binding domains in the protein transcription factor ⅢA from Xenopus oocytes显示文摘 | Miller J McLachlan A D Klug A | | 0，，6： | 1 |
| 6 | Repetitive zinc-binding domains in the protein transcription factor ⅢA from Xenopus ooeytes显示文摘 | MCLACHLAN A D KLUG A | 1985 | EMBO J1985，，4： | 1 |
| 7 | Recrystallization in Oxide-Dispersion Strengthened Mechanically Alloyed Sheet Steel显示文摘 | Klug R C Krauss G Matlock D K | 1996 | Metallurgical and Materials Transactions1996，27，： | 1 |
| 8 | Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes显示文摘 | MILLER J MCLACHLAN A D KLUG A | 1985 | The Embo Journal1985，4，6： | 1 |
| 9 | Risk factors related to infec- tions of implanted pacemakers and cardioverter-defibrillators: results of a large prospective study显示文摘 | Klug D Balde M Pavin D | 2007 | Circulation2007，116，12： | 1 |
| 10 | Pacemaker lead extrac- tion with the needle's eye snare for eountertraction via a femoral approach 显示文摘 | Klug D Jarw6 M Messaoud6ne SA | 2002 | Pacing Clin Eleetrophysiol2002，25，： | 1 |
| 11 | Repetitive zinc - binding domains in the protein transcription factor IIIA from Xenopus oocytes 显示文摘 | Miller J Mclachlan A D Klug A | 1985 | Embo Journal1985，4，6： | 1 |
| 12 | Prevalence and prognostic significance of psychiatric disorders in patients evaluated for recurrent unexplained syncope 显示文摘 | Kouakam C Lacroix D Klug D | 2002 | Am J Cardiol2002，89，5： | 1 |
| 13 | Clinical predictors and prognostic significance of electrical storm in patients with implantable cardioverter defibrillators 显示文摘 | Brigadeau F Kouakam C Klug D | 2006 | Eur Heart2006，27，6： | 1 |
| 14 | Preoperative chemoradiotherapy in the management of oral cancer:a review显示文摘 | Klug C Berzaczy D Voracek M | 2008 | J Craniomaxillofac Surg2008，36，2： | 1 |
| 15 | Zinc fingers:a novel protein fold for nucleic acid recognition显示文摘 | Klug A Rhodes D | | 0，，： | 1 |
| 16 | The role of the central zinc fingers of transcription factor Ⅲ A in binding to 5 S RNA 显示文摘 | SEARLES M A LU D KLUG A | 2000 | J Mol Biol2000，301，1： | 1 |
| 17 | Betaine aldehyde dehydrogenase genes from Arabidopsis with different sub-cellular localization affect stress responses显示文摘 | Missihoun T D Schmitz J Klug R Kirch H H Bartels D | | 0，，： | 1 |
| 18 | Determination of degree of subsitution of sodium carboxymethylcellulose 显示文摘 | Eyler R W Klug E D | 1947 | Analytical Chemistry1947，19，1： | 1 |
| 19 | Description of the interactions during gear rolling as a basis for a method for the prognosis of the attainable quality parameters 显示文摘 | NEUGEBAUER R KLUG D HELLFRITZSCH U | 2007 | Production Engineering2007，1，3： | 1 |
| 20 | Local symptoms at the site of pacemaker implantation indicate latent systemic infection 显示文摘 | Klug D Wallet F Lacroix D | 2004 | Heart2004，90，8： | 1 |
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