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| 1 | β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly显示文摘Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and trafficking.Our aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in GHsecreting adenomas(GHomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 GHomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the GHomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma histotypes.However,its expression was significantly lower in GHomas | Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers SJ Minuto F de Herder W Lamberts SW Ferone D Hofland LJ | 2013 | 中国神经肿瘤杂志2013，11，4： | 2 |
| 2 | Role of the mTOR pathway in normal and tumoral adrenal cells显示文摘 | De Martino MC van Koetsveld PM Pivonello R | 2010 | Neuroendo?crinology2010，92，： | 1 |
| 3 | The novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth hormone- and prolactin-secreting pituitary adenomas in vitro 显示文摘 | Hofland LJ van der Hock J van Koetsveld PM | 2004 | J Clin Endocrinol Metab2004，89，4： | 1 |
| 4 | Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system显示文摘 | Dalm VA van Hagen PM van Koetsveld PM | 2003 | J Clin Endocrinol Metab2003，88，1： | 1 |
| 5 | Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells 显示文摘 | Dalm VA van Hagen PM van Koetsveld PM | 2003 | Am J Physiol2003，285，2： | 1 |
| 6 | The role of roTOR inhibitors in the inhibition of growth and cortisol secre- tion in human adrenocortical carcinoma ceils 显示文摘 | De Martino MC van Koetsveld PM Feelders RA | 2012 | Endocr Relat Cancer2012，19，： | 1 |
| 7 | IFN-beta is a highly potent inhibitor of gastroenteropancreatic neuroendocrine tumor cell growth in vitro显示文摘 | Vitale G de Herder WW van Koetsveld PM | 2006 | Cancer Res2006，66，1： | 1 |
| 8 | Expression of somatostatin, and somatostatin, cortistatin, and Somatostatin receptors in human monocytes, macrophages, and dendritic cells显示文摘 | Dalth VA van Hagen PM van Koetsveld PM | 2003 | Am J Physiol Endocrinol Metab2003，285，2： | 1 |
| 9 | The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells显示文摘 | DE MARTINO MC VAN KOETSVELD PM FEELDERS RA | 2012 | Endocr Relat Cancer2012，19，3： | 1 |
| 10 | Ghre lin and its unacylated isoform stimulate the growth of adrenocor- tical tumor cells via an anti-apoptotie pathway 显示文摘 | DELHANTY PG KOETSVELD PM GAUNA C | 2007 | Am J Physiol Endoerinol Metab2007，293，1： | 1 |
| 11 | Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system显示文摘 | Dalm VA van Hagen PM van Koetsveld PM | 2003 | J Clin Endocrinol Metab2003，88，1： | 1 |
| 12 | Role of the mTOR pathway in normal and tumoral adrenal cells显示文摘 | DE MARTINO MC VAN KOETSVELD PM PIVONELLO R | | 0，，1： | 1 |
| 13 | Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system显示文摘 | Dalm VA van Hagen PM van Koetsveld PM | 2003 | J Clin Endocrinol Metab2003，88，16： | 1 |
| 14 | Potential role of type Ⅰ interferons in the treatment of pituitary adenomas显示文摘 | Vitale G Caraglia M van Koetsveld PM | | 0，，02： | 1 |
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