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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Colonoscopy-induced ischemic colitis in patients without risk factors显示文摘Ischemic colitis is the most common form of intestinal ischemia.It is a condition that is commonly seen in the elderly and among individuals with risk factors for ischemia.Common predisposing conditions for ischemic colitis are major vascular occlusion,small vessel disorder,shock,some medications,colonic obstructions and hematologic disorders.Ischemic colitis following colonoscopy is rare.Here,we report two cases of ischemic colitis after a routine screening colonoscopy in patients without risk factors for ischemia. | Sang Ok Lee Sae Hee Kim Sung Hee Jung Chan Woong Park Min Ji Lee Jin A Lee Hyun Cheol Koo Anna Kim Hyun-Young Han Dong-Wook Kang | 2014 | World Journal of Gastroenterology2014，20，13： | 9 |
| 3 | Stress and sleep quality in doctors working on-call shifts are associated with functional gastrointestinal disorders显示文摘AIM To investigate the role of sleep quality and psychosocial problems as predictors of functional gastrointestinal disorders(FGIDs) in doctors that work 24 hour-on-call shifts.METHODS In this cross-sectional observation study, using the Rome Ⅲ Questionnaire and Pittsburgh Sleep Quality Index(PSQI), we analyzed 170 doctors with 24 houron-call shifts. RESULTS Among the participants that had experienced a 24 hour-on-call shift within the last 6 mo, 48(28.2%) had FGIDs. Overall prevalence of irritable bowel syndrome(IBS) and functional dyspepsia(FD) were 16.5% and 17.1%, respectively, with 5.3% exhibiting both. Sleep scores(PSQI)(8.79 ± 2.71 vs 7.30 ± 3.43, P = 0.008), the presence of serious psychosocial alarm(83.3%vs 56.6%, P = 0.004), and the proportion of doctors who experienced over two months of recent on-call work(81.2% vs 68.9%, P = 0.044) were significantly different between individuals with or without FGIDs. Multivariate analysis revealed that presenting serious psychosocial alarm was an independent risk factor for prevalence of FD(OR = 5.47, 95%CI: 1.06-28.15, P = 0.042) and poor sleep quality(PSQI ≥ 6) was a predictor of IBS(OR = 4.17, 95%CI: 1.92-19.02, P = 0.016). CONCLUSION Physicians should recognize the role of sleep impairment and psychological stress in the development of FGIDs and a comprehensive approach should be considered to manage patients with FGIDs. | Soo-Kyung Lim Seung Jin Yoo Dae Lim Koo Chae A Park Han Jun Ryu Yong Jin Jung Ji Bong Jeong Byeong Gwan Kim Kook Lae Lee Seong-Joon Koh | 2017 | World Journal of Gastroenterology2017，23，18： | 2 |
| 4 | Effect of simulated gastric fluid and bile on survival of Vibrio vulnificus andVibrio vulnificus phage 显示文摘 | Koo J DePaola A Marshall D L | 2000 | J Food Prot2000，63，12： | 1 |
| 5 | Effect of the experimental parameters on the structure of nitrogen-doped carbon nanotubes produced by aerosol chemical vapour deposition 显示文摘 | Koos A A Dowling M Jurkschat K | 2009 | Carbon2009，47，1： | 1 |
| 6 | Laparoscop ic resection of gastric gastrointestinal stromal tumors显示文摘 | Hindmarsh A Koo B LewisMP | 2005 | Surg Endosc2005，19，8： | 1 |
| 7 | The prophylactic use of tranexamic acid and aprotinin in orthotopic liver trans- plantation: a comparative study显示文摘 | Dalmau A Sabate A Koo M | 2004 | Liver Transpl2004，10，2： | 1 |
| 8 | Laparoscopic resection of gastric gastrointestinal stromal tumors显示文摘 | Hinarsh A Koo B Lewis MP | 2005 | Surg Endosc2005，19，8： | 1 |
| 9 | Effective daily treatment with clomipramine in men with premature ejaculation when 25 mg (as required ) is ineffective 显示文摘 | Rowland DL De Gouveia Brazao CA Koos Slob A | 2001 | BJU Int2001，87，4： | 1 |
| 10 | Meningiomas ofthe space of the cavernous sinus显示文摘 | Knosp E Perneczky A Koos WT | 1996 | J Neurosurg1996，38，： | 1 |
| 11 | Feature-based operation sequence generation in CAPP 显示文摘 | Irani S A Koo H Y Raman S | 1995 | lnternational Journal of Production Research1995，33，1： | 1 |
| 12 | Targeting of cell-surface betaamyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments 显示文摘 | Haass C Koo EH Mellon A | 1992 | Nature1992，357，6378： | 1 |
| 13 | Effects of compounds found in propolis on streptococcus mutans growth and on glucosyltransferase activity显示文摘 | KOO H ROSALEN P L CURY J A | 2003 | Antimicrobila a Gents and Chemotherapy2003，46，5： | 1 |
| 14 | Fully nonlinear wave-body interactions with fully submerged dual cylinders显示文摘 | Koo W Kim MH Tavassoli A | | 0，，： | 1 |
| 15 | Detection of L isteria monocytogenes from a model food by fluorescence resonance energy trunsferbased PCR with an asymmetric fluorogenic probe set显示文摘 | KOO K JAYKUS L A | 2003 | App 1 Environ Microbiol2003，69，2： | 1 |
| 16 | The prophylactic use of tranexamic acid and aprotinin in orthotopic liver transplantation:a comparative study显示文摘 | Dalmau A Sabata A Koo M | 2004 | Liver Transpl2004，10，2： | 1 |
| 17 | AGV dispatching based on workload balancing显示文摘 | Kim C W Tanchoco J M A Koo P H | 1999 | International Journal of Production Research1999，37，： | 1 |
| 18 | Tacrolimus ointment is safe and effective in the treatment of atopic dermatitis:results in 8000 patients显示文摘 | Koo J Y Fleischer A B Jr Abramovits W | 2005 | J Am Acad Dermatol2005，53，2： | 1 |
| 19 | Meningiomas of the space of the cavernous sinus 显示文摘 | Knosp E Perneczky A Koos WT | 1996 | Neurosurgery1996，38，： | 1 |
| 20 | International trade and foreign direct investment:Substitutes or compliments 显示文摘 | Marchant M A Cornell D W Koo | 2002 | Journal of Agricultural and Applied Economics2002，34，2： | 1 |
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