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| 1 | Association of XPG rs2094258 polymorphism with gastric cancer prognosis显示文摘BACKGROUND The xeroderma pigmentosum group G(XPG)gene at chromosome 13q33 consists of 15 exons,which may be related to the occurrence and development of gastric cancer(GC).AIM To examine the association of several common single nucleotide polymorphisms(SNPs)of the XPG gene with GC risk and survival.METHODS Five SNPs of XPG(rs2094258,rs751402,rs873601,rs2296147,and rs1047768)were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North China.GC patients were followed for survival status and,if deceased,cause of death.Logistic regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis,respectively.For rs2094258,heterozygous model(CT vs CC),homozygous model(TT vs CC),recessive model(TT vs CT+CC),and dominant model(TT+CT vs CC)were analyzed.RESULTS None of the examined loci were statistically associated with GC risk,although rs2296147 was marginally associated with GC risk(P=0.050).GC patients with the rs2094258 CT+CC genotype showed worse survival than those with the TT genotype(log-rank test,P=0.028),and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT+CT genotype(log-rank test,P=0.039).The increase in C alleles of rs2094258[hazard ratio(HR)=1.19,95%confidence interval(CI):1.02-1.45,P=0.037]were associated with the long-term survival of GC cases.Other risk factors for survival included tumor differentiation(HR=4.51,95%CI:1.99-8.23,P<0.001),lymphovascular invasion(HR=1.97,95%CI:1.44-3.01,P<0.001),and use of chemotherapy(HR=0.81,95%CI:0.63-0.98,P=0.041).CONCLUSION The XPG rs2094258 polymorphism may be associated with overall survival in GC patients. | Xiao-Qin Wang Paul D Terry Yang Li Yue Zhang Wen-Jing Kou Ming-Xu Wang | 2019 | World Journal of Gastroenterology2019，25，34： | 4 |
| 2 | Association between interleukin-21 gene rs907715 polymorphism and gastric precancerous lesions in a Chinese population显示文摘BACKGROUND The single nucleotide polymorphisms of interleukin-21(IL-21)gene were confirmed to be related to various diseases,but no studies have examined the possible role of IL-21 single nucleotide polymorphisms(SNPs)(rs907715,rs2221903,and rs12508721)in gastric precancerous lesions.AIM To explore the associations between SNPs of IL-21 gene(rs907715,rs2221903,and rs12508721)and gastric precancerous lesions in a Chinese population.METHODS Three SNPs of IL-21 were genotyped using polymerase chain reaction–ligase detection reaction in 588 cases and 290 healthy controls from May 2013 to December 2016 in northwestern China.Gastric precancerous lesions were confirmed by endoscopic examination and categorized as non-atrophic gastritis,atrophic gastritis,and intestinal metaplasia.Descriptive statistic and logistic regression were used for data analyses.RESULTS IL-21 rs907715 genotype CC and C frequencies were higher in in patients with gastric precancerous lesions than in the controls(OR=1.59,95%CI:1.06-2.38,P=0.013;OR=1.28,95%CI:1.01-2.22,P=0.044,respectively)after adjusting for confounding factors.For SNP rs907715 in intestinal metaplasia patients,significant differences between cases and controls were observed in the frequencies of genotype CC and C(OR=1.92,95%CI:1.24-2.98,P=0.004;OR=1.53,95%CI:1.04-2.24,P=0.028,respectively);for non-atrophic gastritis and atrophic gastritis patients,the CC and C genotypes showed no significant association with risk in all models.No association between either rs2221903 or rs12508721 and gastric precancerous lesions was found in the present study.In the haplotype analysis,the TC haplotype(rs907715 and rs12508721)and TT haplotype(rs2221903 and rs907715)were more frequent in the case group than control group(P<0.05).CONCLUSION Our findings indicate that SNP rs907715 of IL-21 gene is associated with gastric precancerous lesions.The TC haplotype(rs907715 and rs12508721)and TT haplotype(rs2221903 and rs907715)increased the risk of gastric precancerous lesions.If confirmed,these findings will shed light on the etiology of precancerous lesions. | Xiao-Qin Wang Yang Li Paul D Terry Wen-Jing Kou Yue Zhang Zhao-Zhao Hui Xiao-Han Ren Ming-Xu Wang | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 2 |
| 3 | Size exclusion chromato-graphy with Corona charged aerosol detector for the analysisof polyethylene glycol polymer显示文摘 | Kou D Manius G Zhan S | 2009 | J Chromatogr A2009，1216，28： | 1 |
| 4 | Influence of acupuncture on remodeling ofswallowing functions for patients with pseudobulbar palsy aftercerebral infarction显示文摘 | Liu D Tong X Kou JY | 2012 | J Acupunct Tuina Sci2012，10，1： | 1 |
| 5 | Hepatopancreas is the extraovarian site of vitellogenin synthesis in black tiger shrimp,Penaeus Molwdon 显示文摘 | Yseng D Y Chen Y N Kou G H | 2001 | Comparative Biochemistry and Physiology2001，129，： | 1 |
| 6 | The Analytic Hierarchy Process:Task Scheduling and Resource Allocation in Cloud Computing Envi-ronment显示文摘 | Ergu D Kou G Peng Y | | 0，，： | 1 |
| 7 | Supported liquid membrane microextraction with high-performance liquid chromatography-UV detection for monitoring trace haloacetic acids in water显示文摘 | KOU D WANG X Y MITRA S | 2004 | Journal of Chromatography A2004，1055，12： | 1 |
| 8 | Femtocell base station deployment in commercial buildings: A global optimization approach 显示文摘 | LIU Jia KOU Tian-you CFIEN Qian SHERALI H D | 2012 | 1EEE Journal on Selected Areas in Communications2012，30，3： | 1 |
| 9 | Canine Population Data Generated fi:om a Multiplex STR Kit for Use in Forensic Casework 显示文摘 | Kanthaswamy S Ttom BK Mattila A-M Johnston E Dayton M Kinaga J Erickson B J-A Halverson J Fantin D Denise S Kou A Malladi V Satkoski J Budowle B Smith DG Koskinen MT | 2009 | Journal of Forensic Sciences2009，54，4： | 1 |
| 10 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 11 | The analytic hierarchy process:task scheduling and resource allocation in cloud computing environment显示文摘 | Ergu D Kou G Peng Y | 2013 | The Journal of Super Computing2013，64，3： | 1 |
| 12 | Enhaneed M1/M2 maerophage ratio promotes orthodontic root resorption显示文摘 | He D Kou X Luo Q | 2015 | J Dent Res2015，94，1： | 1 |
| 13 | Ionic Liquids:Applications in Catalysis显示文摘 | Zhao D B Wu M Kou Y | 2002 | Catal Today2002，74，： | 1 |
| 14 | Scripta Materialia显示文摘 | Kou D P Li J R Yu J L | 2008 | 59(5): 4832008，59，5： | 1 |
| 15 | An improved statistical approach for consistency test in AHP显示文摘 | Lin C S Kou G Ergu D | 2013 | Annals of Operations Research2013，211，1： | 1 |
| 16 | Pathogenisis of Vibrio vulnificus ( Mini Review) 显示文摘 | LIN KOUS D A OLIVER J D | 1999 | FEMs Microbiol Letters1999，174，： | 1 |
| 17 | Microstructure and microsegregation in directionally solidified Mg-4A1 alloy 显示文摘 | ZHANG C MA D WU K S CAO H B CAO G P KOU S | 2007 | Intermetallics2007，15，10： | 1 |
| 18 | Ionic liquid: application in catalysis 显示文摘 | Zhao D B Wu M Kou Y | 2002 | Catal Today2002，74，： | 1 |
| 19 | Min E, Ionic liquids: apphcations in catalysis 显示文摘 | Zhao D B Wu M Kou Y | 2002 | Catal Today2002，74，12： | 1 |
| 20 | Influence of fly ash as cement replacement on the properties of recycled aggre- gate concrete显示文摘 | Kou S C Poon C S Chan D | 2007 | Journal of Materials in Civil Engi- neering2007，19，9： | 1 |
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