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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Changes of microbial population and some components in carrot juice during fermentation with selected Bifidobacterlum strains显示文摘 | KUN S REZESSY-SZABO J M NGUYEN Q D | 2008 | Process Bio- chemistry2008，43，8： | 1 |
| 3 | A Y chromosome gene family with RNA-Binding protein homology: candidates for azoospermia factor AZF controlling human spermatogenesis 显示文摘 | John D Andrew S | 1993 | Cell1993，75，： | 1 |
| 4 | Diagnostic relevance of interleukin pattern,acute-phase proteins and procalcitonin in early phase of post-ERCP pancreatitis显示文摘 | Oezcueruemez-Porsch M Kun Z D | 1998 | Dig Dis Sci1998，43，80： | 1 |
| 5 | Thermal circuit for SOIMOSFET structure accounting for nonisothermal effects显示文摘 | Zhang Kun Cheng M C | 2010 | IEEE Transactions on Electron Devices2010，57，11： | 1 |
| 6 | Expression of the Sox11 gene in mouse embryos suggests roles in neuronal maturation and epithelio- mesenchymal induction显示文摘 | Hargrave M Wright E Kun J | 1997 | Dev Dyn1997，210，： | 1 |
| 7 | A study on mRNA expressions of fibrenectin in dermal and cerebral wound healing for wound age estimation显示文摘 | Takamiya M KunⅢgai R Nakayashiki N | 2006 | Leg Med(Tokyo)2006，8，4： | 1 |
| 8 | CD44 mediates constitutive type I receptor signaling in cervical carcinoma cells 显示文摘 | Wobus M Kuns R Wolf C | 2001 | Gynecol Oncol2001，83，2： | 1 |
| 9 | Specific Associanon of Human Telomerase Activity with Immortal Cells and Cancer显示文摘 | KUN N W PRATYSZEK M A PROWSE K R | 1994 | Science1994，266，5193： | 1 |
| 10 | The effect of Si()2 shellthickness on the magnetic properties of ZnFe204nanoparticles 显示文摘 | Co§kun M Korkmaz M | 2014 | Journal of nanoparticle research2014，16，3： | 1 |
| 11 | Titania-sepiolite nanocomposites prepared by a surfactant templating colloidal route显示文摘 | ARANDA P KUN R MARTIN-LUENGO M A | 2008 | Chem Mater2008，20，1： | 1 |
| 12 | Silencing of two alternative splicing - derived mRNA variants of chitin synthasel gene by RNAi is lethal to the oriental migratory locust, Locusta migratoria manilensis (Meyen) 显示文摘 | Zhang JZ Enbo M Kun YZ | 2010 | Insect Biochemistry and Molecular Biology2010，40，11： | 1 |
| 13 | A new instrument for the diagnosis of tumors 显示文摘 | Kun M | | Month J Med Sci0，7，： | 1 |
| 14 | The role of HER2 in cancer therapy and targeted drug delivery显示文摘 | Wanyi T Rubi M Kun Ch | 2010 | Control Release2010，146，3： | 1 |
| 15 | Indirect reference intervalsestimated from hospitalized population for thyrotropin and freethyroxine显示文摘 | Inal TC Serteser M Co§kun A | 2010 | Croat Med J2010，51，： | 1 |
| 16 | Indirect Reference Intervals Estimated from Hospitalized Population for Thyrotropin and Free Thyroxine显示文摘 | Inal TC Serteser M Co~kun A | 2010 | Croat Med J2010，51，2： | 1 |
| 17 | Changes ofmicrobial population and some components in carrot juice during fer-mentation with selected Bifidobacterium strains显示文摘 | KUN S REZESSY-SZABO J M NGUYEN Q D | 2008 | Process Biochemistry2008，43，8： | 1 |
| 18 | Expression of the Soxll gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenehymal induction显示文摘 | HARGRAVE M WRIGHT E KUN J | 1997 | Dev Dyn1997，210，： | 1 |
| 19 | Iden- tiffed olfactory ensheathing cells transplanted into the transec- ted dorsal funiculus bridge the lesion and form myelin显示文摘 | SASAKI M LANKFORD K L ZEME KUN M | 2004 | J Neurosci2004，24，39： | 1 |
| 20 | Prevalence of post-traumatic stress disorder in Sichuan Province,China after the 2008 Wenchuan earthquake显示文摘 | Kun P Chen X Han S Gong X Chen M Zhang W | | 0，，11： | 1 |
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