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| 1 | Ten-year survival of hepatocellular carcinoma patients undergoing radiofrequency ablation as a first-line treatment显示文摘AIM: To investigate the long-term survival and prognostic factors in hepatocellular carcinoma(HCC) patients undergoing radiofrequency ablation(RFA) as a first-line treatment.METHODS: From 2000 to 2013, 316 consecutivepatients with 404 HCC(1.0-5.0 cm; mean: 3.2 ± 1.1 cm) underwent ultrasonography-guided percutaneous RFA as a first-line treatment. There were 250 males and 66 females with an average age of 60.1 ± 10.8 years(24-87 years). Patients were followed for 1 year to > 10 years after RFA(234, 181, 136, and 71 for 3, 5, 7, and 10 years, respectively). Overall local response rates and long-term survival rates were assessed. Survival results were generated using Kaplan-Meier estimates, and multivariate analysis was performed using the Cox regression model. RESULTS: In total, 548 RFA sessions were performed and major complications occurred in 10 sessions(1.8%). Local tumor progression and/or new tumor development were observed in 43.3%(132/305) of the patients during the follow-up period. Overall 5-and 10-year survival rates were 49.7% and 28.4%, respectively. Based on multivariate analysis, three factors were identified as independent prognostic factors for overall survival: Child-Pugh classification(HR = 4.054, P < 0.001), portal vein hypertension(HR = 2.743, P = 0.002), and tumor number(HR = 2.693, P = 0.003). The local progression-free 5- and 10-year survival rates were 42.7% and 19.5%. In addition to the Child-Pugh classification and the number of tumors, the number of RFA sessions(HR = 1.550, P = 0.002) was associated with local progression-free survival.CONCLUSION: RFA can achieve acceptable outcomes for HCC patients as a first-line treatment, especially for patients with Child-Pugh class A, patients with a single tumor and patients without portal vein hypertension. | Wei Yang Kun Yan S Nahum Goldberg Muneeb Ahmed Jung-Chieh Lee Wei Wu Zhong-Yi Zhang Song Wang Min-Hua Chen | 2016 | World Journal of Gastroenterology2016，22，10： | 20 |
| 2 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 3 | 迈向二十一世纪的中国粮食:回顾与展望显示文摘中国未来粮食的发展方向已经成为当今国内外各界人士关注的焦点。国外一些学者认为中国粮食进口将直线上升,并在不久的未来超出世界粮食生产能力,使国际市场粮食价格上升,不但给中国未来也给世界缺粮的低收入国家带来危机。而不少中国经济学家并不这样认为,他们相信中... | 黄季Kun Rozel.,S | 1996 | 农业经济问题1996，17，1： | 12 |
| 4 | Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma:A Pediatric Brain Tumor Consortium Study显示文摘PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received two doses of BVZ | Gururangan S Chi SN Young Poussaint T Onar-Thomas A Gilbertson RJ Vajapeyam S Friedman HS Packer RJ Rood BN Boyett JM Kun LE | 2010 | 中国神经肿瘤杂志2010，8，2： | 7 |
| 5 | Projection of the Zhujiang(Pearl) River Delta's potential submerged area due to sea level rise during the 21st century based on CMIP5 simulations显示文摘Projections of potential submerged area due to sea level rise are helpful for improving understanding of the influence of ongoing global warming on coastal areas. The Ensemble Empirical Mode Decomposition method is used to adaptively decompose the sea level time series in order to extract the secular trend component. Then the linear relationship between the global mean sea level(GMSL) change and the Zhujiang(Pearl) River Delta(PRD)sea level change is calculated: an increase of 1.0 m in the GMSL corresponds to a 1.3 m(uncertainty interval from1.25 to 1.46 m) increase in the PRD. Based on this relationship and the GMSL rise projected by the Coupled Model Intercomparison Project Phase 5 under three greenhouse gas emission scenarios(representative concentration pathways, or RCPs, from low to high emission scenarios RCP2.6, RCP4.5, and RCP8.5), the PRD sea level is calculated and projected for the period 2006–2100. By around the year 2050, the PRD sea level will rise 0.29(0.21 to 0.40) m under RCP2.6, 0.31(0.22 to 0.42) m under RCP4.5, and 0.34(0.25 to 0.46) m under RCP8.5, respectively.By 2100, it will rise 0.59(0.36 to 0.88) m, 0.71(0.47 to 1.02) m, and 1.0(0.68 to 1.41) m, respectively. In addition,considering the extreme value of relative sea level due to land subsidence(i.e., 0.20 m) and that obtained from intermonthly variability(i.e., 0.33 m), the PRD sea level will rise 1.94 m by the year 2100 under the RCP8.5scenario with the upper uncertainty level(i.e., 1.41 m). Accordingly, the potential submerged area is 8.57×103 km2 for the PRD, about 1.3 times its present area. | XIA Jiangjiang YAN Zhongwei ZHOU Wen FONG Soi Kun LEONG Ka Cheng TANG Iu Man CHANG S W LEONG W K JIN Shaofei | 2015 | Acta Oceanologica Sinica2015，34，9： | 3 |
| 6 | Empirical Analysis of the Impact on the Citizenization of Rural Migrant Workers from Urban-rural Dual Institution显示文摘In the article,we attribute the main institutional reasons for impacts on citizenization of migrant workers to the urban-rural dual institution, and analyze its content and the basic characteristics.Then empirical analysis of the impact on the will, the ability,decision-making and process of citizenization of migrant workers is given by use of Logistic regressive model and investigation data.Finally a result is found that although the migrant workers have a strong desire for becoming citizens, the vast majority of migrant workers can not be converted to the public because of their capacity constraints, so as soon as possible to improve their ability of citizenization becomes the key to promote citizenization of migrant workers;furthermore,in the urban-rural dual institution,in addition to the household registration system,the employment system, the social security system,the land system and the education system have obvious obstacles on the will, the ability decision-making and process of citizenization of migrant workers.Therefore,the future focus of innovation of the urban-rural dual institution can not continue to remain in the formal aspects of the household registration system,but as soon as possible to switch to innovation of the employment system,the social security system,the land system and the education system which have a substantial impact on the rights and benefits of rural migrant workers,such as expectations and income. | Huang Kun PhD and Associate Professor,Institute of China’s Economic Reform and Development, Renmin University of China. | 2011 | China Population Today2011，30，5： | 2 |
| 7 | Efficient construction of multibit tries for IP lookup显示文摘 | Sahni S Kun Suk Kim | 2003 | IEEE/ACM Transactions on Networking2003，11，4： | 2 |
| 8 | Eigenstructure Method for Robust Array Processing显示文摘 | Youn W S Kun C | 1990 | Electronics Letters1990，26，10： | 1 |
| 9 | Nitrogen doped porous carbon fibres as anode materials for sodium ion batteries with excellent rate performance显示文摘 | LIJUN F KUN T KEPENG S | 2014 | Nanoscale2014，6，： | 1 |
| 10 | Postharvest responses of Chinese bay berryfruit 显示文摘 | WANG S Z KUN S C ZHANG B | 2005 | Postharvest Biology Technology2005，37，： | 1 |
| 11 | Biodegradable interpolyelectrolyte complexes based on methoxy poly(ethylene glycol)-b-poly(a,1-glutamic acid) and chitosan显示文摘 | Kun L Jingbo Y Zhijiang S | 2008 | Biomacromolecules2008，9，10： | 1 |
| 12 | Changes of microbial population and some components in carrot juice during fermentation with selected Bifidobacterlum strains显示文摘 | KUN S REZESSY-SZABO J M NGUYEN Q D | 2008 | Process Bio- chemistry2008，43，8： | 1 |
| 13 | A Y chromosome gene family with RNA-Binding protein homology: candidates for azoospermia factor AZF controlling human spermatogenesis 显示文摘 | John D Andrew S | 1993 | Cell1993，75，： | 1 |
| 14 | Prevalence of post - traumatic stress disorder in Siehuan Province, China after the 2008 Wenchuan earthquake显示文摘 | Kun P Chen X Hart S | 2009 | Public Health2009，123，： | 1 |
| 15 | Diaphragm pacers as a treat- ment for congenital central hypoventilation syndrome 显示文摘 | Chen ML Tablizo MA Kun S | 2005 | Expert Rev Med Devices2005，2，5： | 1 |
| 16 | Research on the WeChat Information Transmission Topology Based on Social Network Analysis 显示文摘 | W Kun S Duoyong | 2015 | OpenCybernetics & Systemics Journal2015，，： | 1 |
| 17 | An innovative for packaging power electronics building blocks using metal posts interconnected parallel plate structures显示文摘 | Kun X Lin R L | 1999 | IEEE Transactions on Advanced Packaging1999，22，2： | 1 |
| 18 | Alkylation of 2- Propanoic Acid tert-Butyl Ester显示文摘 | SEIJI S KENICHIRO Y KUN L E | 2013 | Org Synth2013，90，： | 1 |
| 19 | Microstructure and mechanical properties of the Mg-Gd-Y-Zn-Zr alloy fabricated by semi-continuous casting 显示文摘 | XU Chao ZHENG Ming-yi WU Kun KAMADO S | 2012 | Materials Science and Engineering A2012，549，： | 1 |
| 20 | Triterpenoids from the Roots of Dipsacus asper 显示文摘 | Keun Y J Kun H S Jae C | 1993 | Archives of Pharmacal Research1993，16，1： | 1 |
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