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| 1 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 2 | Kinetics of allantoin metabolism in sheep 显示文摘 | KAHN L P NOLAN J V | 2000 | British Journal of Nutrition2000，84，： | 1 |
| 3 | A mitochondrial myopathy characterized by a deficiency in reducible cytochrome b 显示文摘 | Morgn-Hues JA Darveniza P Kahn SN | 1977 | Brain1977，100，4： | 1 |
| 4 | Uniform pricing or pay-as-bid prieing:a dilemma for California and beyond显示文摘 | KAHN A E CRAMTON P C PORTER R H | 2001 | The Electricity Journal2001，14，6： | 1 |
| 5 | Glucose transporters and insulin action 显示文摘 | SHEPHERD P R KAHN B B | 1999 | N Engl J Med1999，341，4： | 1 |
| 6 | Supermarket tour:The effect of presentation mode on nutrition knowledge and attitudes显示文摘 | Kahn RF O'Sullivan P Vannatta PM | 2003 | Fam Med2003，35，10： | 1 |
| 7 | A programmatic approach to studying the industrial environment and mental healthl显示文摘 | French J R P Kahn R L | 1962 | Journal of Sociallssues1962，18，3： | 1 |
| 8 | Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation显示文摘 | MCGETTRICK A J FEENER E P KAHN C R | 2005 | J Biol Chem2005，280，： | 1 |
| 9 | Secondary ion mass spectrometry(SIMS) microscopy: A new tool for pharmacological studies in humans显示文摘 | Fragu P Kahn E | 1997 | Microsc Res Tech1997，36，： | 1 |
| 10 | From genome to proteome:looking at a cell's proteins显示文摘 | Kahn P | 1995 | Science1995，270，： | 1 |
| 11 | Zebrafish hit the big time 显示文摘 | KAHN P | 1994 | Science1994，264，5161： | 1 |
| 12 | A fast line finder for vision-guided robot navigation 显示文摘 | KAHN P KITCHEN L RISEMAN E M | 1990 | IEEE Transactions on Pattern Analysis and Machine Intelligence1990，12，11： | 1 |
| 13 | Form genome to proteome:looking at a cell's proteins显示文摘 | Kahn P | 1995 | Science1995，270，5235： | 1 |
| 14 | Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control cell cycle progression and gene expression显示文摘 | Jiang W Kahn SM Zhon P | 1993 | Oncogene1993，8，12： | 1 |
| 15 | Age at initiation and frequency of screen- ing to detect type 2 diabetes: a cost-effectiveness analysis 显示文摘 | Kahn R Alperin P Eddy D | 2010 | Lancet2010，375，9723： | 1 |
| 16 | Introduction: One Health perspective显示文摘 | Monath T P Kahn L H Kaplan B | 2010 | ILAR J2010，51，3： | 1 |
| 17 | Arabidoposis RAR1 exerts rate limiting control of R gene-mediated defenses against muhiple pathogens 显示文摘 | Muskett P R Kahn K Austin M J | 2002 | Plant Ce112002，14，5： | 1 |
| 18 | Preparation and function of the hypertension converting enzyme 显示文摘 | SKEGGS L T KAHN J R SHUMWAY N P | 1956 | Journal of Experimental Medicine1956，103，3： | 1 |
| 19 | Myotube-specific activity of the human aldolase A M-promoter requires an overlapping binding site for NF1 and MEF2 factors in addition to a binding site(M1) for unknown proteins显示文摘 | Salminen M Spitz F Fiszman MY Demignon J Kahn A Daegelen D Maire P | | 0，，01： | 1 |
| 20 | Specific deficiency of p561ck expression in T lymphocytes from type 1 diabetic patients 显示文摘 | NERVI S ATLAN G C KAHN P B | 2000 | J Immunol2000，165，10： | 1 |
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