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| 1 | Role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning显示文摘AIM: To investigate the role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning (IPC).METHODS: A rat model of acute hepatic ischemia-reperfusion was established, 24 healthy male Wistar rats were randomly divided into sham-operated group, ischemia-reperfusion group (IR) and IPC group. IPC was achieved by several brief pre-reperfusions followed by a persistent reperfusion.Concentration of malondialdehyde (MDA) and activity of several antioxidant enzymes in hepatic tissue were measured respectively. Apoptotic cells were detected by TdT-mediated dUTP-biotin nick end labeling (TUNEL) and expression of Bcl-2 protein was measured by immunohistochemical techniques. Moreover, mitochondrial ultrastructure and parameters of morphology of the above groups were observed by electron microscope.RESULTS: Compared with IR group, the concentration of MDA and the hepatocellular apoptotic index in IPC group was significantly reduced (P<0.05), while the activity of antioxidant enzymes and OD value of Bcl-2 protein were markedly enhanced (P<0.05). Moreover, the injury of mitochondrial ultrastructure in IPC group was also obviously relieved.CONCLUSION: IPC can depress the synthesis of oxygen free radicals to protect the mitochondrial ultrastructure and increase the expression of Bcl-2 protein that lies across the mitochondrial membrane. Consequently, IPC can reduce hepatocellular apoptosis after reperfusion and has a protective effect on hepatic ischemia-reperfusion injury. | KaiSun Zhi-SuLiu QuanSun | 2004 | World Journal of Gastroenterology2004，10，13： | 86 |
| 2 | Received Signal StrengthBased Wireless Localization via SemidefiniteProgramming:Noncooperative and Cooperative Schemes显示文摘 | Robin Wentao Ouyang-Albert KaiSun Wong-ChinTau Lea | 2010 | IEEETransactions on Vehicular2010，59，3： | 1 |
| 3 | The Dynamics and Volatility of Commercial and Residential Property Prices:Theory and Evidence显示文摘 | Kwong Sunny KaiSun and Charles KaYui Leung | | Journal of Regional Science0，2004，： | 1 |
| 4 | Plasma Klotho and Cardiovascular Disease in Adults显示文摘 | Richard D.Semba Anne R.Cappola KaiSun StefaniaBandinelli MansiDalal CandaceCrasto Jack M.Guralnik LuigiFerrucci | 2011 | Journal of the American Geriatrics Society2011，，9： | 1 |
| 5 | Protection of GBE50 on brain mitochondria in rats with hyperlipidemia显示文摘AIM To study the protective effects of the new standardized preparation of Ginkgo biloba extracts(GBE50) anainst brain mitochondrial damages induced by hyperlipemia in rats. METHODS Rat model with hyperlipemia was established by feeding the young male SD rats (3 weeks after born) with high lipid food for 3 months. Then the rats were treated with different dosage of GBE50(ig) for 4 weeks. The prophylaxis rat group were fed with the mixture of high lipid food and GBE50 (50mg/kg/d). The brain mitochondria was separated for determination of the R3, R4 and RCR of the respiration function with the method of Clark's electrode. The mitochondrial transmembrane potential(Δψm) was derected by the Rho123 assay and the cytochrome c release was checked by spectrography. In addition, the parameters of oxidative stress (the activities of SOD, GSH-Px, and the MDA leve) and the activities of ATPase were assayed. | KaiSUN GangLIU Yun-xuanZHANG Ghen-liangYIN Gaj-junTIAN Jia-huPAN | 2005 | 中国药理通讯2005，22，2： | 0 |
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