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| 1 | The Wnt/β-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma显示文摘The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology,and many studies have focused on the role of this signaling pathway in tumor cells.However,it is now clear that tumor development and metastasis depend on the two-way interaction between cancer cells and their environment,thereby forming a tumor microenvironment(TME).In this review,we discuss how Wnt/β-catenin signaling regulates cross-interactions among different components of the TME,including immune cells,stem cells,tumor vasculature,and noncellular components of the TME in hepatocellular carcinoma.We also investigate their preclinical and clinical insights for primary liver cancer intervention,and explore the significance of using Wnt/β-catenin mutations as a biomarker to predict resistance in immunotherapy. | Kaiting Wang Xinyao Qiu Yan Zhao Hongyang Wang Lei Chen | 2022 | Cancer Biology & Medicine2022，19，3： | 2 |
| 2 | Synthesis of new SAM-forming ferrocene derivatives and their interfacial properties on gold显示文摘 | Ka(z)em(e)kait(e) M Bulovas A Smirnovas V | 2001 | Tetrahedron Lett2001，42，43： | 1 |
| 3 | Effect of alkyl chain length on the thermophysical properties of pyridinium carboxylates显示文摘In the present study, new series of pyridinium carboxylate protic ionic liquids(PILs) were synthesized by pairing pyridinium cation with carboxylate anion from C_1–C_3 forming pyridinium formate([C_5H_6N^+][HCOO^-]),pyridinium acetate([C_5H_6N^+][CH_3COO^-]) and pyridinium propionate([C_5H_6N^+][CH_3CH_2COO^-]) respectively.The physical properties namely, density, viscosity, surface tension(298.15–343.15) K, and refractive index(293.15–323.15) K were measured. Thermal properties namely, glass transition temperature, molar heat capacity, and thermal decomposition temperatures were also determined. The thermal expansivity was calculated using the experimental density data. The effect of increasing the alkyl chain length on the thermophysical properties of the pyridinium carboxylate PILs has been evaluated. As expected the physical properties i.e. density,viscosity, surface tension and refractive index of the investigated pyridinium carboxylates decreased with increasing temperature. In general pyridinium carboxylate PILs possessed low viscosity, high thermal stability and excellent hydrogen bonding capability, and these properties lead them to outperform conventional solvents employed for lignin dissolution. | Tazien Rashid Chong Fai Kait Thanabalan Murugesan | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 1 |
| 4 | Automatic quantification of ejection fraction from gated myocardial perfusion SPECT显示文摘 | Germano G Kait H Kavanagh P B | 1995 | J Nucl Med1995，36，1： | 1 |
| 5 | Lysine- based structure responsible for selective mannose phosphorylatin of Cathepsin D and Cathepsin L defines a common structural motif for lysosomal enzyme targeting显示文摘 | John WC KaiT Mirek C | 1998 | J Biol Chem1998，273，21： | 1 |
| 6 | Magnetic and R/W properties of CoPt-SiO2 granular media显示文摘 | KAITS I INOMATA A OKAMOTO I | 1998 | IEEE Transaction on Magnetics1998，34，4： | 1 |
| 7 | Identification of severe and extensive coronary artery disease by automatic measurement of transient ischemic dilation of the left ventricle in dual-isotope myocardial perfusion SPECT显示文摘 | Mazzanti M Germano G Kait H | 1996 | J Am Coll Cardiol1996，27，7： | 1 |
| 8 | A new KKM theorem in L-conve spaces and some applications显示文摘 | WEN Kaiting | 2008 | Comput Math Appl2008，56，： | 1 |
| 9 | Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding arteriosclerosis,thrombosis,and vascular显示文摘 | George A Robert A Kait J | 1999 | Biology1999，19，： | 1 |
| 10 | Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding 显示文摘 | Truskey GA Herrmann RA Kait J | 1999 | Arterioscler Thromb Vasc Biol1999，19，： | 1 |
| 11 | Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding arteriosclerosis,thrombosis,and vascular显示文摘 | George A Robert A Kait J | 1999 | Biology1999，19，3： | 1 |
| 12 | UV/H202 oxidation of azo dyes in aqueous media: Evidence of a structure degradability relationship 显示文摘 | GALINDO C KAIT A | 2007 | Dyes Pigm2007，42，3： | 1 |
| 13 | Automatic quantification of ejection fraction from gated myocardial perfution SPECT显示文摘 | Germano G Kait H Kavanagh PB | 1995 | J Nucl Med1995，36，1： | 1 |
| 14 | Quality of life and voice in patients treated for early laryngeal cancer显示文摘 | SIUPSINSKIENE N VAITKUS S GREBLIAUS- KAITE M | 2008 | Medicina (Kau- nas)2008，44，： | 1 |
| 15 | Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-suseeptible sites in the rabbit aorta after short-term cholesterol feeding显示文摘 | TRUSKEY G A HERRMANN R A KAIT J | 1999 | Arterioscler Thromb Vase Biol1999，19，： | 1 |
| 16 | Molecular spectrum of thalassemia in tropical Hainan Island of southern China:high allele frequency with low health burden显示文摘Thalassemia is the most common monogenetic disorder prevalent in tropical and subtropical regions.It is mainly classified into aandβ-thalassemia according to which globin chain is affected(Taher et al.,2018).Thalassemia mutations present significant genetic diversity,which causing absent(a~0 andβ~0)or reduced(a+andβ+)synthesis of globin chains.Consequently,homozygotes or compound heterozygotes of different thalassemia alleles can lead to various clinical phenotypes. | Yanquan Lai Fangchao Tao Yu Zou Min Huang Kaiting Lin Yang Li Weilun Huang Wanjun Zhou | 2022 | Journal of Genetics and Genomics2022，49，12： | 1 |
| 17 | Dissolution of kraft lignin using Proticlonic Liquids and characterization显示文摘 | Rashid T Kait C F Regupathi I | 2016 | Industrial Crops and Products2016，84，： | 1 |
| 18 | Methanol and DME Co-production from CO2 hydrogenation over hybrid catalysts显示文摘 | Noor Asmawati Mohd Zabidi Muhammad Zahiruddin Ramli Fai Kait Chong | 2009 | Journal of Chemistry and Chemical Engineering2009，3，12： | 0 |
| 19 | New insights into cell-cell communications during seed development in flowering plants显示文摘The evolution of seeds is a major reason why flowering plants are a dominant life form on Earth.The developing seed is composed of two fertilization products,the embryo and endosperm,which are surrounded by a maternally derived seed coat.Accumulating evidence indicates that efficient communication among all three seed components is required to ensure coordinated seed development.Cell communication within plant seeds has drawn much attention in recent years.In this study,we review current knowledge of cross-talk among the endosperm,embryo,and seed coat during seed development,and highlight recent advances in this field. | Wei Wang Hanxian Xiong Kaiting Sun Bo Zhang Meng-Xiang Sun | 2022 | Journal of Integrative Plant Biology2022，64，2： | 0 |
| 20 | Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways显示文摘Objective: This study is designed to investigate the mode of action of the synergistic effect of 5-fluorouracil(5-FU) and magnolol against cervical cancer.Methods: Network pharmacological approach was applied to predict the molecular mechanism of 5-FU combined with magnolol against cervical cancer. CCK-8 assay, colony formation assay, immunofluorescence staining, adhesion assay, wound healing mobility assay, cell migration and invasion assay and Western blot analysis were conducted to validate the results of in silico study.Results: Phosphatidylinositol 3 kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR) signaling pathway was identified as the key pathway in silico study. The experimental results showed that 5-FU combined with magnolol strongly inhibited cervical cancer cell proliferation, induced the morphological change of HeLa cells by down-regulating the expression of a-actinin, tensin-2 and vinculin. Moreover, magnolol enhanced inhibitory effect of 5-FU on the cell adhesion, migration and invasion. The phosphorylation of AKT and PI3K and the expression of mTOR were strongly inhibited by the combination of 5-FU and magnolol. Moreover, the expression of E-cadherin and β-catenin was upregulated and the expression of Snail, Slug and vimentin was down-regulated by the 5-FU together with magnolol.Conclusion: Taken together, this study suggests that 5-FU combined with magnolol exerts a synergistic anti-cervical cancer effect by regulating the PI3K/AKT/mTOR and epithelial-mesenchymal transition(EMT) signaling pathways. | Yuanyuan Chen Shanshan Chen Kaiting Chen Lanfang Ji Shuna Cui | 2024 | Chinese Herbal Medicines2024，16，1： | 0 |
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