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| 1 | The influence of asymptomatic inflammatory prostatitis on the onset and progression of lower urinary tract symptoms in men with histologic benign prostatic hyperplasia显示文摘Benign prostatic hyperplasia(BPH)is a condition that greatly affects the quality of life of middle-aged and elderly men.Histopathologically,hyperplastic changes frequently occur in the prostate tissue of elderly men,the incidence of which has been reported to reach approximately 80% in men in their 70s.In clinical practice,approximately 25% of men with histologic BPH are assumed to experience lower urinary tract symptoms(LUTS)and receive some kind of treatment.In other words,there are some men with histologic BPH who do not exhibit LUTS.For that reason,many factors,such as the change in hormonal environment,the immune or autoimmune response,the alteration of gene expression,and so on,are thought to affect the onset and progression of LUTS in men with histologic BPH.One such factor that has long drawn attention is the presence of asymptomatic histological inflammation,which very often accompanies symptomatic BPH.Recent studies have suggested that asymptomatic histological inflammation causes repeated destruction,healing,and regeneration of the prostate tissue,leading to the enlargement of prostatic nodules,while at the same time causing stromal tissuepredominant remodeling of the prostate tissue,which can increase urination resistance and result in the condition changing from asymptomatic BPH to symptomatic BPH.In future,the biomolecular clarification of the significance of asymptomatic histological inflammation in the prostate tissue could help develop new treatment strategies for BPH accompanied by LUTS. | Rikiya Taoka Yoshiyuki Kakehi | 2017 | Asian Journal of Urology2017，4，3： | 9 |
| 2 | High temperature oxidation behavior of aluminide on a Ni-based single crystal superalloy in different surface orientations显示文摘An investigation on oxidation behavior of coated Ni-based single crystal superalloy in different surface orientations has been carried out at1100 ℃. It has been found that the {100} surface shows a better oxidation resistance than the {110} one, which is attributed that the {110}surface had a slightly higher oxidation rate when compared to the {100} surface. The experimental results also indicated that the anisotropic oxidation behavior took place even with a very small difference in the oxidation rates that was found between the two surfaces. The differences of the topologically close packed phase amount and its penetration depth between the two surfaces, including the ratio of α-Al2O3 after 500 h oxidation, were responsible for the oxidation anisotropy. | Fahamsyah H.Latief Koji Kakehi El-Sayed M.Sherif | 2014 | Progress in Natural Science:Materials International2014，24，2： | 2 |
| 3 | 积极监测是区分致死性与非致死性前列腺癌亚型的可行方法显示文摘如何区分致死性与非致死性前列腺癌亚型在预防前列腺癌过度治疗方面已经成为一个非常重要的课题,尤其在这个用前列腺特异性抗原筛查可使前列腺癌的死亡率下降大于20%的时代。然而,判断初次诊断的患者是否会受益于立即干预治疗是非常困难的。以某种监测项目来随访看起来不需要立即治疗的患者,即所谓的“积极监测”,是弥补过度治疗的一种可行的方法。本综述讨论了积极监测的利弊,对提高积极监测结果的影像和新的生物标记的未来前景也进行了展望。 | Yoshiyuki Kakehi | 2012 | Asian Journal of Andrology2012，14，3： | 2 |
| 4 | Updated results from the European Randomized Study of Prostate-Specific Antigen (PSA) Screening for Prostate Cancer: are Asian countries encouraged to promote PSA screening?显示文摘 | Mikio Sugimoto Yoshiyuki Kakehi | 2012 | Asian Journal of Andrology2012，14，4： | 2 |
| 5 | Role of matrix metalloproteinase- 9 in the basement membrane destruction of superficial urothelial carci- noma显示文摘 | Ozdemir E Kakehi Y Okuno H | 1999 | J Urol1999，161，4： | 1 |
| 6 | TRAIL and chemotherapeutic drugs in cancer therapy显示文摘 | Wu XX Ogawa O and Kakehi Y | 2004 | Vitam Horm2004，67，： | 1 |
| 7 | Polyamines:Ubiquitous polycations with unique roles in growth and stress responses显示文摘 | Takahashi T Kakehi J I | 2010 | Annals of Botany2010，105，1： | 1 |
| 8 | Synthesis and properties of novel crown ether-annelated At,5'-diaza-9'-(1,3-dithiole-2-ylidene)-fluorenes and their ruthenium(Ⅱ)complexes显示文摘 | SAKO K KAKEHI T NAKANO S | 2014 | Tetrahedron Letters2014，55，3： | 1 |
| 9 | Role of matrix metalloproteinase-9 in the basement membrane destruction of superficial urothetial careinomas 显示文摘 | Ozdemir E Kakehi Y Okuno H | 1999 | J Urol1999，161，： | 1 |
| 10 | Distinct microsatellite alterations in upper urinary tract tumors and subsequent bladder tumors显示文摘 | Takahashi T Kakehi Y Mitsumori K | 2001 | J Urol2001，165，2： | 1 |
| 11 | Role of matrix metallo-proteinase- 9 in the basement membrane destruction of superficial urothelial carcinomas显示文摘 | Ozdemir E Kakehi Y Okuno H | 1999 | J Urol1999，161，4： | 1 |
| 12 | Bladder cancer produ- cing granulocyte colony-stimulating factor显示文摘 | Ito N Matsuda T Kakehi Y | 1990 | N Engl J Med1990，323，24： | 1 |
| 13 | NOX enzymes and diabetic complications显示文摘 | Kakehi T Yabe-Nishimura C | | 0，，03： | 1 |
| 14 | Role of matrix metal loproteinase-9 in the basement membrane destruction of superficial urothelial carcinomas显示文摘 | Ozdemir E Kakehi Y Okuno H | 1999 | J Urol1999，161，： | 1 |
| 15 | Molecular targeted therapy for renal cell carcinoma 显示文摘 | Kakehi Y | 2008 | Rinsho Ketsueki2008，49，8： | 1 |
| 16 | Activation of caspase-3 in renal cell carcinoma ceils by anthracyclines or 5-fluorouracil显示文摘 | Wu XX Kakehi Y Mizutani Y | 2001 | Int J Oncol2001，19，1： | 1 |
| 17 | 显示文摘 | Ikeda S Takeguchi N Kakehi M | 2000 | J Magn Soc Jpn2000，24，4： | 1 |
| 18 | Watchful waiting as a treatment option for localized prostate cancer in the PSA era 显示文摘 | Kakehi Y | 2003 | Jpn J Clin Oncol2003，33，1： | 1 |
| 19 | Role of matrix metalloproteinase9 in the basement membrane destruction of superficial urothelial carcinoma显示文摘 | Kakehi Y Okuno H | 1999 | J Urol1999，161，： | 1 |
| 20 | Distinct microsatellite alterations in upper urinary tract tumors and subsequent bladder tumors显示文摘 | TAKAHASHI T KAKEHI Y MITSUMORI K | 2001 | J Urol2001，165，2： | 1 |
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