|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeting LIF/LIFR signaling in cancer显示文摘Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical target for cancer therapy. LIF/LIFR activate oncogenic signaling pathways including JAK/STAT3 as immediate effectors and MAPK, AKT, mTOR further downstream. LIF/LIFR signaling plays a key role in tumor growth, progression, metastasis, stemness and therapy resistance. Many solid cancers show overexpression of LIF and autocrine stimulation of the LIF/LIFR axis;these are associated with a poorer relapse-free survival. LIF/LIFR signaling also plays a role in modulating multiple immune cell types present in tumor micro environment (TME). Recently, two targeted agents that target LIF (humanized anti-LIF antibody, MSC-1) and LIFR inhibitor (EC359) were under development. Both agents showed effectivity in preclinical models and clinical trials using MSC-1 antibody are in progress. This article reviews the significance of LIF/LIFR pathways and inhibitors that disrupt this process for the treatment of cancer. | Suryavathi Viswanadhapalli Kalarickal V.Dileep Kam Y.J.Zhang Hareesh B.Nair Ratna K.Vadlamudi | 2022 | Genes & Diseases2022，9，4： | 4 |
| 2 | Magnetic Properties and Structural Implications for Nanocrystalline Fe-Ti-N ThinFilms显示文摘 | Das J Kalarickal S S Kim K S | 2007 | Phys Rev B2007，75，09： | 1 |
| 3 | Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia? 显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Paediatr Anaesth2005，15，12： | 1 |
| 4 | Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia?显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Paediatr Anaesth2005，15，12： | 1 |
| 5 | Dipeptidyl pepti -dase - 4 as a new target of action for type 2 diabetes mellitus : a systematic review 显示文摘 | Wani J H John -Kalarickal J Fonseca V A | 2008 | Cardiol C1in2008，26，： | 1 |
| 6 | Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based gen- eral anesthesia? 显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Paediatr Anaesth2005，15，12： | 1 |
| 7 | Does dexmedetomidine prevent emergence delirium in children after sevoflurane- based general anesthesia显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Pediatr Anesth2005，15，4： | 1 |
| 8 | Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia?显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Paediatr Anaesth2005，15，12： | 1 |
| 9 | Does Dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Paediatric anaesthesia2005，15，12： | 1 |
| 10 | Does dexme- detomidine prevent emergence delirium in children after sevoflurane-hased general anesthesia? 显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Paediatr An- aesth2005，15，12： | 1 |
| 11 | Does dexmedetomi- dine prevent emergence delirium in children after sevoflurane-based general anesthesia 显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Paediatr Anaesth2005，15，12： | 1 |
| 12 | Dose dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia显示文摘 | SHUKRY M CLYDE M C KALARICKAL P L | | 0，，12： | 1 |
| 13 | Does dexmedeto- midine prevent emergence delirium in children after sevoflu- rane-based general anesthesia 显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Pediatr Anesth2005，15，12： | 1 |
| 14 | Does dexmedetomidine prevent emergence delirium in children after sevoflurane - based general anesthesia? 显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Paediatr Anaesth2005，15，12： | 1 |
| 15 | EC330, a small-molecule compound, is a potential novel inhibitor of LIF signaling显示文摘Dear Editor,LIF,a multi-functional cytokine,is frequently overexpressed in many human cancers,including breast,colorectal,and pancreatic cancers(Liu et al.,2013;Li et al.,2014;Yu et al.,2014;Pascual-Garcia et al.,2019;Shi et al.,2019;Wang et al.,2019).LIF overexpression is frequently associated with poor prognosis in human cancers(Liu et al.,2013;Li et al.,2014;Yu et al.,2014).LIF functions through binding to LIF receptor complex composed of LIF receptor(LIF-R)and glycoprotein gp130(Taga and Kishimoto,1997;Heinrich et al.,2003;Watanabe et al.,2006).LIF overexpression induces activation of several oncogenic signaling pathways in a cell/tissue type-specific manner,including STAT3,PI3K/AKT,and mTOR,which in turn promotes proliferation,metastasis,and therapeutic resistance of cancer cells(Liu et al.,2013;Li et al.,2014;Yu et al.,2014;Shi et al.,2019).Recent studies have suggested that LIF is a potential important target for cancer therapy,especially for cancers with LIF overexpression.LIF neutralization antibodies(LIF neu Abs)have been reported to block LIF signaling and largely abolish the promoting effect of LIF on cancer progression(Li et al.,2014;Yue et al.,2016;Shi et al.,2019). | Xuetian Yue Fangnan Wu Jianming Wang Kaitlin Kim Bindu Santhamma Kalarickal VDileep Kam YJZhang Suryavathi Viswanadhapalli Ratna KVadlamudi Gulzar Ahmed Zhaohui Feng Klaus Nickisch Wenwei Hu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 16 | Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia? 显示文摘 | SHUKRY M CLYDE MC KALARICKAL PL | 2005 | Paediatr Anaesth2005，15，12： | 1 |
| 17 | Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia显示文摘 | Shukry M Clyde MC Kalarickal PL | | 0，，12： | 1 |
| 18 | Optimized pulsed laser deposited barium ferrite thin films with narrow ferromagnetic resonance line widths显示文摘 | Song Y Y Kalarickal S Carl E | 2003 | J Appl Phys2003，94，5： | 1 |
| 19 | Doesdexmedetomidine prevent emergence delirium in children aftersevoflurane-based general anesthesia?显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Pediatr Anesth2005，15，12： | 1 |
| 20 | Does dexmedeto- midine prevent emergence delirium in children after sevoflurane-based general anesthesia?显示文摘 | Shukry M Clyde MC Kalarickal PL | 2005 | Padiatr Anaesth2005，15，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员