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| 1 | The role of chemosensory protein 10 in the detection of behaviorally active compounds in brown planthopper, Nilaparvata lugens显示文摘Chemosensory proteins(CSPs)play important roles in insects’chemoreception,although their specific functional roles have not been fully elucidated.In this study,we conducted the developmental expression patterns and competitive binding assay as well as knock‐down assay by RNA interference both in vitro and in vivo to reveal the function of NlugCSP10 from the brown planthopper(BPH),Nilaparvata lugens(Stål),a major pest in rice plants.The results showed that NlugCSP10 messenger RNA was significantly higher in males than in females and correlated to gender,development and wing forms.The fluorescence binding assays revealed that NlugCSP10 exhibited the highest binding affinity with cis‐3‐hexenyl acetate,eicosane,and(+)‐β‐pinene.Behavioral assay revealed that eicosane displayed attractant activity,while cis‐3‐hexenyl acetate,similar to(+)‐β‐pinene significantly repelled N.lugens adults.Silencing of NlugCSP10,which is responsible for cis‐3‐hexenyl acetate binding,significantly disrupted cis‐3‐hexenyl acetate communication.Overall,findings of the present study showed that NlugCSP10 could selectively interrelate with numerous volatiles emitted from host plants and these ligands could be designated to develop slow‐release mediators that attract/repel N.lugens and subsequently improve the exploration of plans to control this insect pest. | Muhammad Irfan Waris Aneela Younas Muhammad Muzammal Adeel Shuang-Gang Duan Sundas Rana Quershi Rana Muhammad Kaleem Ullah Man-Qun Wang | 2020 | Insect Science2020，27，3： | 9 |
| 2 | 基于模糊语言变量的动态目标无线网络选择技术(英文)显示文摘Even though various wireless Network Access Technologies(NATs)with different specifications and applications have been developed in the recent years,no single wireless technology alone can satisfy the anytime,anywhere,and any service wireless-access needs of mobile users.A real seamless wireless mobile environment is only realized by considering vertical and horizontal handoffs together.One of the major design issues in heterogeneous wireless networks is the support of Vertical Handoff(VHO).VHO occurs when a multi-interface enabled mobile terminal changes its Point of Attachment(PoA)from one type of wireless access technology to another,while maintaining an active session.In this paper we present a novel multi-criteria VHO algorithm,which chooses the target NAT based on several factors such as user preferences,system parameters,and traffic-types with varying Quality of Service(QoS)requirements.Two modules i.e.,VHO Necessity Estimation(VHONE)module and target NAT selection module,are designed.Both modules utilize several'weighted'users’and system’s parameters.To improve the robustness of the proposed algorithm,the weighting system is designed based on the concept of fuzzy linguistic variables. | Faisal Kaleem Abolfazl Mehbodniya Arif Islam Kang K.Yen Fumiyuki Adachi | 2013 | China Communications2013，10，1： | 6 |
| 3 | MicroRNA targets the ecdysone signaling pathway E75 gene to control larval-pupal development in Bactrocera dorsalis显示文摘MicroRNAs (miRNAs) regulate various biological processes during insect developme nt;however, their role in larval-pupal development in oriental fruit fly, Bactrocera dorsalis (Hendel) remains unknown. In the current study, we address the biological function of a conserved miRNA, Bdo-Let-7 in the regulation of BdE75 gene, which belongs to the ecdysone signaling pathway and participates in the larval-pupal development in B. dorsalis. Using dual luciferase reporter assay in HEK293T cells we show that Bdo-Let-7 miRNA interacts with the 3' untranslated region of BdE75 gene and suppresses its expression. The Bdo-Let?7 and BdE75 are also co-expressed in the larval-pupal stages and in different tissues of B. dorsalis .In in vivo experiments, the injectio n of Bdo-Let-7 agomir and antagomir in third instar larvae down- and up-regulated the expression of BdE75、 respectively. The 20-hydroxyecdysone (20E) injection assay shows that 20E up-regulated the expression of Bdo-Let-7 on the 5th day of the larvae. Moreover, abnormal pupation and eclosion were observed after larval Bdo-Let-7 antagomir injection. Based on these results, we show that Bdo-Let-7 regulates the ecdysone signaling pathway through the exact dose of BdE75 gene, and is indispensable for normal larval-pupal development in B. dorsalis. | Wei Peng Wei-Wei Zheng Kaleem Tariq Shu-Ning Yu Hong-Yu Zhang | 2019 | Insect Science2019，26，2： | 4 |
| 4 | Methylglyoxal increases dopamine level and leads to oxidative stress in SH-SY5Y cells显示文摘越来越多的研究建议了 type-2 糖尿病导致的 methylglyoxal (MGO ) 与 Parkinson 的疾病(PD ) 有关。然而,很少对分子的机制被知道。在这研究,我们在 neuroblastoma SH-SY5Y 房间探索了 MGO 毒性。MGO 的 Neurotoxicity 被 mitochondrial 膜潜力, malondialdehyde,和 methylthiazoletetrazolium 试金测量。多巴胺, 3,4-dihydroxyphenylacetic 酸(DOPAC ) ,和 1-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (salsolinol ) 的层次被液体 chromatographymass spectrometry/mass spectrometry 检测。酷氨酸 hydroxylase (TH ) 和多巴胺 transporter (DAT ) 的表情被反向的 transcriptase 聚合酶链反应和西方的污点分析检测。当多巴胺, DOPAC,和内长的神经毒素 salsolinol 的层次也增加了时,结果证明 MGO 在 SH-SY5Y neuroblastoma 房间在 TH 和 DAT 表情导致了增加。Aminoguanidine (AG ) 是 MGO 的一个禁止者。AG 能减少,这被发现反应的氧种类(ROS ) 水平由 MGO 导致了,但是不能禁止 TH, DAT 和多巴胺的增加。多巴胺, DOPAC 和 salsolinol 层次的增加能导致高 ROS 和 mitochondrial 损坏。当 MGO 在糖尿病的功课期间被增加时,这研究建议多巴胺引起的 ROS 能贡献 dopaminergic 神经原的损坏。 | Bingjie Xie Fankai Lin Lei Peng Kaleem Ullah Hanyan Wu Hong Qing Yulin Deng | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 4 |
| 5 | Luminous composite ultrathin films of CdTe quantum dots/silk fibroin co-assembled with layered doubled hydroxide:Enhanced photoluminescence and biosensor application显示文摘Quantum dots(QDs)luminescent films are extensively applied to optoelectronics and optical devices.However,QDs aggregation results in the quenching of their fluorescence property which limits their practical applications to a greater extent.In order to resolve this issue,3-mercaptopropionic acid(3-MPA)functionalized Cadmium Tellurium(CdTe)QDs were stabilized by silk fibroin(SB)and coassembled with layered doubled hydroxide(LDH)to form(QDs@SF/LDH)_(n)ultrathin films(UTFs)via the layer-by-layer(LBL)technique.UV-Vis absorption and fluorescence spectroscopy showed a stepwise and normal growth of the films upon increasing the number of deposition cycles.XRD and AFM studies confirmed the formation of a periodic layered structure and regular surface morphology of the thin films.As compared to(CdTe QDs/LDH)_(n)UTFs,the(CdTe QDs@SF/LDH)_(n)UTFs displayed fluorescence enhancement and longer fluorescent lifetime,both in solid states and aqueous solutions.Furthermore compared with the solution state,the fluorescence enhancement of SF-RC and SF-β are,respectively,7 times and 17 times in the(CdTe QDs@SF/LDH)_(n)UTFs,indicating that the LDH nanosheets favor the fluorescence enhancement effect on the CdTe QDs@SF.The fabricated materials displayed fluorescence response to a biological molecule such as immune globulin,lgG.Thus,the(CdTe QDs@SF/LDH)_(n)UTFs has a potential to be used as biosensor. | Muhammad Sohail Haroone Ling Li Aftab Ahmad Yaping Huang Ruili Ma Ping Zhang Yuehua Hu Qari Muhammad Kaleem Jun Lu | 2018 | Journal of Materiomics2018，4，2： | 3 |
| 6 | Characteristic spectral studies and in vitro antifungal activity of some Schiff bases and their organotin (Ⅳ) complexes显示文摘The synthesis and in vitro antifungal activity of some Schiff bases and their Sn (Ⅳ) complexes has been tested against plant pathogenic fungi and it is found that they possess excellent fungicidal activity. On the basis of ^1H-, ^13C-,^119Sn NMR-, ^119Sn Mǒssbauer, IR and Elemental analysis the tetrahedral geometry is proposed for the synthesized compounds. | Wajid Rehman Musa Kaleem Baloch Bakhtiar Muhammad Amin Badshah Khalid M.Khan | 2004 | Chinese Science Bulletin2004，49，2： | 3 |
| 7 | Application of Islamic banking instrument (Bai Salam) for agriculture financing in Pakistan显示文摘 | Ahmad Kaleem Rana Abdul Wajid | 2009 | British Food Journal2009，，3： | 2 |
| 8 | Influence of rainfall infiltration on the stability of unsaturated coal gangue accumulated slope显示文摘The slope instability is associated with increasing rate of rainfall infiltration which cause shear strength reduction and suction loss and the slope tend to failure. The influences of rainfall infiltration on the stability of clayey and sandy slopes have been analyzed but the effect of rainfall infiltration on the stability of unsaturated coal gangue accumulated slope was needed to study. Therefore, a coal gangue accumulated slope prone to failure in Fuxin area of Northeast China was considered to evaluate its failure mechanism under different rainfall events. The effects after five different rainfall events on slope stability were physically analyzed, numerically investigated and the results from both uncoupled(hydraulic) and coupled(hydromechanical) responses were compared using finite element analysis. It was observed that the decisive soaking and leaching under different rainfall conditions caused maximum deformation at the crest of slope due to maximum value of permeability coefficient of coal gangue. The critical duration of moderate intensity(147 mm/day) of rainfall for the instability of coal gangue accumulated slope is declared as five days. The results from finite element analysis in this paper further clarifies that increase in duration of rainfall infiltration process cause hysteretic change in positive pore-water pressure causing decrease in factor of safety and increase in deformation. It is concluded that the stability of unsaturated coal gangue accumulated slope is greatly influence by the coupled effect of stress and porewater pressure in comparison of uncoupled(hydraulic) analysis as the obtained factor of safety values after five days of rainfall infiltration were 0.9 and 1.1 respectively. | Kaleem Ullah Jan KHAN WANG Chang-ming Muhammad Wasim Jan KHAN LIANG Zhu LI Shuo LI Bai-long | 2021 | Journal of Mountain Science2021，18，6： | 2 |
| 9 | Rectal ulcers and massive bleeding after hemorrhoidal band ligation while on aspirin显示文摘Endoscopic hemorrhoidal band ligation is a well-established nonoperative method for treatment of bleeding internal hemorrhoids(grade 1 to 3). It is a safe and effective technique with a high success rate. Complications with this procedure are uncommon. Although rectal ulceration due to band ligation is a rare complication, it can cause life-threatening hemorrhage especially when patients are on medications which impair hemostasis like aspirin or non steroidal antiinflammatory drugs. We present 2 cases of massive lower gastro-intestinal bleeding in patients who had a band ligation procedure performed 2 wk prior to the presentation and were on aspirin at home. Both the patients were hemodynamically unstable requiring resuscitation. They required platelet and blood transfusions and were found to have rectal ulcers on colonoscopy done subsequently. The rectal ulcers corresponded to the site of band ligation. The use of aspirin by these patients would have caused defects in the hemostasis and may have predisposed them to massive bleeding in the presence of rectal ulcers occurring after the band ligation procedure. Managing aspirin before and after the ligation may be difficult especially since adequate guidelines are unavailable. Stopping aspirin in all the cases might not be safe and the decision should be individualized. | Shruti Patel Ghulamullah Shahzad Kaleem Rizvon Krishnaiyer Subramani Prakash Viswanathan Paul Mustacchia | 2014 | World Journal of Clinical Cases2014，2，4： | 2 |
| 10 | In vivo screening of essential oils of Skimmia laureola leaves for antinociceptive and antipyretic activity显示文摘Objective:To study the screening of essential oils of Skimmia laureola leaves(SLO)for acute toxicity,antinociceptive,antipyretic and anticonvulsant activities in various animal models.Methods:SLO were extracted using modified Clevenger type apparatus.Acute toxicity test was used in mice to observe its safety level.Antinociceptive activity of SLO was evaluated in acetic acid induced writhing and hot plate tests.Yeast induced hyperthermic mice and pentylenetetrazole induced convulsive mice were used for the assessment of its antipyretic and anticonvulsant profile respectively.Results:Substantial safety was observed for SLO in acute toxicity test.SLO showed a high significant activity in acetic acid induced writhing test in a dose dependent manner with maximum pain attenuation of 68.48%at 200 mg/kg i.p.However,it did not produce any relief in thermal induced pain at test doses.When challenged against pyrexia evoked by yeast,SLO manifested marked amelioration in hyperthermic mice,dose dependently.Maximum anti-hyperthermic activity(75%)was observed at 200 mg/kg i.p.after 4 h of drug administration.Nevertheless,SLO had no effect on seizures control and mortality caused by pentylenetetrazole.Conclusions:In vivo studies of SLO showed prominent antinociceptive and antipyretic activities with ample safety profile and thus provided pharmacological base for the traditional uses of the plant in various painful conditions and pyrexia.Additional detail studies are required to ascertain its clinical application. | Naveed Muhammad Barkatullah Muhammad Ibrar Haroon Khan Muhammad Saeed Amir Zada Khan Waqar Ahmad Kaleem | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，3： | 2 |
| 11 | Comparative analysis of greenhouse gas emission inventory for Pakistan:Part I energy and industrial processes and product use显示文摘In order to further improve the accuracy and reliability and reduce uncertainties in the national GHG inventories for Pakistan,this study call for using 2006 IPCC Guidelines,to help to identify the national targets for GHG mitigation with respect to the nationally determined contributions(NDCs).GHG(CO2,CH4,and N20)inventories for Pakistan have been developed by conducting a detailed sectoral assessment of IPCC source sectors,energy,industrial processes and product use(IPPU),agriculture,forestry and other land use(AFOLU),and the waste sector.Further,sector wise comparative analysis of GHG inventories(1994-2017)based on the 2006 and 1996 IPCC Guidelines have also been presented.Results indicated an average relative difference of 4%in total GHG emissions(CO2 equivalent)from energy sector between 2006 and 1996 IPCC Guidelines.With 3.6%average annual growth rate based on 2006 IPCC Guidelines,CO2 from energy sector remained the most abundant GHG emitted,followed by CH4 and N2O.While the average absolute difference in emissions of CH4 and N20 from the energy sector is notable,the total estimated GHG emissions by 2006 IPCC Guidelines duplicate those by 1996 IPCC Guidelines.In the mineral industry with 2006 IPCC Guidelines,an average annual growth rate of 6.7%is observed,contributing 64%of total IPPU sector CO2 emissions.Nevertheless,the relative difference between the two Guidelines in overall IPPU sector emissions remained negligible.There might be a need for switching to 2006 IPCC Guidelines to consider more parameters such as additional source sectors and new default emission factors that fit into national circumstances. | Kaleem Anwar MIR Chunkyoo PARK Pallav PUROHIT Seungdo KIM | 2020 | Advances in Climate Change Research2020，11，1： | 1 |
| 12 | Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats 显示文摘 | KALEEM M ASIF M AHMED Q U | 2006 | Singapore Med J2006，47，8： | 1 |
| 13 | Acute promyelocytic leukemia with additional chromosomal abnormalities and absence of Auer rods显示文摘 | Kaleem Z Watson MS Zutter MM | 1999 | Am J Clin Pathol1999，112，1： | 1 |
| 14 | Biosynthesis of gly cyrrhetic acid 3-O-mono-l/I-D-glucuronide catalyzed by l>glucuronidase with enhanced bond selectivity in an i onic liquid/buffer biphasic system显示文摘 | He D M Kaleem I Qin S Y | 2010 | Process Biochem istry2010，45，12： | 1 |
| 15 | A comparative study of flow boiling heat transfer in three different configurations of microehannels 显示文摘 | Prajapati Y K Pathak M Kaleem K M | 2015 | International Journal of Heat and Mass Transfer2015，85，： | 1 |
| 16 | Diagnostic criteria for minimally differentiated acute myeloid leukemia (AML-M0), Evaluation and a proposal 显示文摘 | Kaleem Z White G | 2001 | Am J Clin Pathol2001，115，6： | 1 |
| 17 | A fuzzy extension of VIKOR for target network selection in heterogeneous wireless environments 显示文摘 | Abolfazl Mehbodniya Faisal Kaleem Kang K Yen | 2013 | Physical Communication2013，7，11： | 1 |
| 18 | Tissue factor expression and angiogenesis in human protaste carcinoma显示文摘 | Abdulkadir SA Carvalhal GF Kaleem Z | 2000 | Hum Pathol2000，31，： | 1 |
| 19 | Hyalinzing trabecular adenoma of the thyroid:A report of two cases with cytologic,histologic and immunohistochemical findings显示文摘 | Kaleem Z Davila RM | 1997 | Acta Cytol1997，41，3： | 1 |
| 20 | Application of Lslamic Bank- ing Instrument ( Bai Salam) for Agriculture Financing in Pakistan 显示文摘 | Ahmad Kaleem Rana Abdul Wajid | 2009 | British Food Journal2009，111，3： | 1 |
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