|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prolonged survival in patients with hand-foot skin reaction secondary to cooperative sorafenib treatment显示文摘BACKGROUND Sorafenib is an oral drug that prolongs overall survival(OS)in patients with hepatocellular carcinoma.Adverse events,including hand-foot skin reaction(HFSR),lead to permanent sorafenib discontinuation.AIM To clarify the association between interventions for adverse events and patient prognosis.METHODS We performed a retrospective,multicenter study of patients treated with sorafenib monotherapy between May 2009 and March 2018.We developed a mutual cooperation system that was initiated at the start of sorafenib treatment to effectively manage adverse events.The mutual cooperation system entailed patients receiving consultations during which pharmacists provided accurate information about sorafenib to alleviate the fear and anxiety related to adverse events.We stratified the patients into three groups:Group A,patients without HFSR but with pharmacist intervention;Group B,patients with HFSR and pharmacist interventions unreported to oncologists(nonmutual cooperation system);and Group C,patients with HFSR and pharmacist interventions known to oncologists(mutual cooperation system).OS and time to treatment failure(TTF)were evaluated using the Kaplan-Meier method.RESULTS We enrolled 134 patients(Group A,n=41;Group B,n=30;Group C,n=63).The median OS was significantly different between Groups A and C(6.2 vs 13.9 mo,p<0.01)but not between Groups A and B(6.2 vs 7.7 mo,P=0.62).Group A vs Group C was an independent OS predictor(HR,0.41;95%CI:0.25-0.66;P<0.01).In Group B alone,TTF was significantly lower and the nonadherence rate was higher(P<0.01).In addition,the Spearman’s rank correlation coefficients between OS and TTF in each group were 0.41(Group A;P<0.01),0.13(Group B;P=0.51),and 0.58(Group C;P<0.01).There was a highly significant correlation between OS and TTF in Group C.However,there was no correlation between OS and TTF in Group B.CONCLUSION The mutual cooperation system increased treatment duration and improved prognosis in patients with HFSR.Future prospective studies(e.g.,randomized controlled trials)and improved adherence could help prevent OS underestimation. | Masanori Ochi Toshiro Kamoshida Masahiro Araki Tadashi Ikegami | 2021 | World Journal of Gastroenterology2021，27，32： | 2 |
| 2 | High total Joule heat increases the risk of post-endoscopic submucosal dissection electrocoagulation syndrome after colorectal endoscopic submucosal dissection显示文摘BACKGROUND We hypothesized that thermal damage accumulation during endoscopic submucosal dissection(ESD)causes the pathogenesis of post-ESD electrocoagulation syndrome(PECS).AIM To determine the association between Joule heat and the onset of PECS.METHODS We performed a retrospective cohort study in patients who underwent colorectal ESD from May 2013 to March 2021 in Japan.We developed a novel device that measures swift coagulation time with a sensor adjacent to the electrosurgical coagulation unit foot switch,which enabled us to calculate total Joule heat.PECS was defined as localized abdominal pain(visual analogue scale≥30 mm during hospitalization or increased by≥20 mm from the baseline)and fever(temperature≥37.5 degrees or white blood cell count≥10000μ/L).Patients exposed to more or less than the median Joule heat value were assigned to the high and low Joule heat groups,respectively.Statistical analyses included Mann-Whitney U and chisquare tests and logistic regression and receiver operating characteristic curve(ROC)analyses.RESULTS We evaluated 151 patients.The PECS incidence was 10.6%(16/151 cases),and all patients were followed conservatively and discharged without severe complications.In multivariate analysis,high Joule heat was an independent PECS risk factor.The area under the ROC curve showing the correlation between PECS and total Joule heat was high[0.788(95%confidence interval:0.666-0.909)].CONCLUSION Joule heat accumulation in the gastrointestinal wall is involved in the onset of PECS.ESD-related thermal damage to the peeled mucosal surface is probably a major component of the mechanism underlying PECS. | Masanori Ochi Ryosuke Kawagoe Toshiro Kamoshida Yukako Hamano Haruka Ohkawara Atsushi Ohkawara Nobushige Kakinoki Yuji Yamaguchi Shinji Hirai Akinori Yanaka Kiichiro Tsuchiya | 2021 | World Journal of Gastroenterology2021，27，38： | 2 |
| 3 | Transforming growth factor-beta induces transcription factors MafK and Bachl to suppress expression of the heme oxygenase-1 gene显示文摘 | Okita Y Kamoshida A Suzuki H | 2013 | J Bid Chem2013，288，20： | 1 |
| 4 | Immuno- staining of thymidylate synthase and p53 for predicting chemoresistance to S-1/cisplatin in gastric cancer显示文摘 | Kamoshida S Suzuki M Shimomura R | 2007 | Br J Cancer2007，96，2： | 1 |
| 5 | Is the function of chief cells closely influenced by ECL cells?显示文摘 | Kamoshida S Saito E Fukuda S | 1999 | J Gastroenterol1999，34，： | 1 |
| 6 | Determination of full-length cDNA nucleotide sequence of equine carbonic anhydrase VI and its expression in various tissues显示文摘 | OCHIAI H KANEMAKI N KAMOSHIDA S | 2009 | J Vet Med Sci2009，71，9： | 1 |
| 7 | Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage- like cells by proteolytically processed laminin-332 (laminin-5) 显示文摘 | Kamoshida G Ogawa T Oyanagi J | 2014 | Clin Exp Metastasis2014，，31： | 1 |
| 8 | Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer: implication of TS expression in 5-FU-based adjuvant chemotherapy 显示文摘 | Kamoshida S Matsuoka H Ishikawa T | 2004 | Jpn J Clin Oncol2004，34，10： | 1 |
| 9 | A new concept for the nuclear fuel recycle system: ap- plication of the fluoride volatility reprocessing显示文摘 | Kamoshida M Kawamura F Sasahira A | 2000 | Progress in Nuclear Energy2000，37，14： | 1 |
| 10 | Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor显示文摘 | Kakushima N Kamoshida T Hirai S | 2003 | J Gastroenterol2003，38，12： | 1 |
| 11 | Significance of cell pro-liferation markers(minichromosome maintenance protein 7,topoi-somerase IIalpha and Ki-67)in cavital fluid cytology:can we differ-entiate reactive mesothelial cells from malignant cells?显示文摘 | Kimura F Kawamura J Kamoshida s | 2010 | Diagn Cy-topathol2010，38，3： | 1 |
| 12 | Design and implementation of GXP make — A workflow system based on make显示文摘 | Kenjiro Taura Takuya Matsuzaki Makoto Miwa Yoshikazu Kamoshida Daisaku Yokoyama Nan Dun Takeshi Shibata Choi Sung Jun Jun’ichi Tsujii | 2013 | Future Generation Computer Systems2013，，2： | 1 |
| 13 | A 3D shear-lag model considering micro-damage and statistical strength prediction of unidirectional fiber-reinforced composites 显示文摘 | Okabe T Takeda N Kamoshida Y | 2001 | Composites Science and Technology2001，61，： | 1 |
| 14 | Effects of combined administration of DPD-inhibitory oral fluoropyrimidine,S-1,plus paelitaxel on gene expressions of fluoropyrimidine metabolism-related enzymes in human gastric xenografts显示文摘 | Sakurai Y Yoshida I Kamoshida S | | 0，，08： | 1 |
| 15 | Early gastric ca-ncer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor显示文摘 | Kakushima N T Kamoshida S Hirai | | 0，，12： | 1 |
| 16 | Early gastric cancer with Krukenberg tumor and review of cases of in tramucosal gastric cancers with Krukenberg tumol显示文摘 | Kakushima N Kamoshida T Hirai S | 2003 | J Gastroenterol2003，38，12： | 1 |
| 17 | Early gastric' cancer with Krukenherg lllmor atRJ review of cases of inlralnucosal gastric cancers with Krukenberg tumor显示文摘 | Ktlkushima N Kamoshida T Hirtti S | 2003 | J Gastroenteml2003，38，12： | 1 |
| 18 | A 3D shear-lag model considering micro-damage and statistical strength prediction of unidirectional fiber-reinforced composites 显示文摘 | Okabe T Takeda N Kamoshida Y | 2001 | Comp Sci Tech2001，61，12： | 1 |
| 19 | Early gastric cancer with Krukenberg tumor and review of cases of in-tramucosao gastric cancers with Krukenberg tumor显示文摘 | Kakushima N Kamoshida T Hirai S | 2003 | J Gastroentero12003，38，12： | 1 |
| 20 | Multikinase inhibitor-associated hand-foot skin reaction as a predictor of outcomes in patients with hepatocellular carcinoma treated with sorafenib显示文摘AIM To investigate the relationship between the onsets of multikinase inhibitor(MKI)-associated hand-foot skin reaction(HFSR) and prognosis under intervention by pharmacists after the introduction of sorafenib.METHODS We conducted a retrospective study involving 40 patients treated with sorafenib. Intervention by pharmacists began at the time of treatment introduction and continued until the appearance of symptomatic exacerbation or non-permissible adverse reactions. We examined the relationship between MKI-associated HFSR and overall survival(OS) after the initiation of treatment.RESULTS The median OS was 10.9 mo in the MKI-associated HFSR group and 3.4 mo in the no HFSR group, showing a significant difference in multivariate analysis. A multivariate analysis of the time to treatment failure indicated that the intervention by pharmacists and MKI-associated HFSR were significant factors. The median cumulative dose and the mean medication possession ratio were significantly higher in the intervention group than in the non-intervention group. A borderline significant difference was observed in terms of OS in this group.CONCLUSION Intervention by pharmacists increased drug adherence. Under increased adherence, MKI-associated HFSR was an advantageous surrogate marker. Intervention by healthcare providers needs to be performed for adequate sorafenib treatment. | Masanori Ochi Toshiro Kamoshida Atsushi Ohkawara Haruka Ohkawara Nobushige Kakinoki Shinji Hirai Akinori Yanaka | 2018 | World Journal of Gastroenterology2018，24，28： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员