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| 1 | Intracellular transport of hepatitis B virus显示文摘For genome multiplication hepadnaviruses use the tran-scriptional machinery of the cell that is found within the nucleus.Thus the viral genome has to be transported through the cytoplasm and nuclear pore.The intracy-tosolic translocation is facilitated by the viral capsid that surrounds the genome and that interacts with cellular microtubules.The subsequent passage through the nu-clear pore complexes(NPC) is mediated by the nuclear transport receptors importin α and β.Importin α binds to the C-terminus of the capsid protein that comprises a nuclear localization signal(NLS).The exposure of the NLS is regulated and depends upon genome maturation and/or phosphorylation of the capsid protein.As for oth-er karyophilic cargos using this pathway importin α inter-acts with importin β that facilitates docking of the import complex to the NPC and the passage through the pore.Being a unique strategy,the import of the viral capsid is incomplete in that it becomes arrested inside the nuclear basket,which is a cage-like structure on the karyoplas-mic face of the NPC.Presumably only this compartment provides the factors that are required for capsid disas-sembly and genome release that is restricted to those capsids comprising a mature viral DNA genome. | Michael Kann André Schmitz Birgit Rabe | 2007 | World Journal of Gastroenterology2007，13，1： | 6 |
| 2 | 四城市初中生吸烟与不健康行为的关系研究显示文摘目的了解北京、杭州、武汉和乌鲁木齐四城市初中生的吸烟情况,并分析其吸烟行为与多种危害健康的行为和心理问题的关系。方法中国疾病预防控制中心(CDC)健康教育所提供四城市所有中学资料,由美国CDC用特殊的抽样软件从中抽取100所学校,采用WHO的全球学校学生健康调查问卷对9015名初中生进行调查。结果参加调查的初中生尝试吸烟率为29.496,过去30d中6.6%的学生使用过烟草。27.0%的吸烟学生在9岁及以前开始吸第1支烟,31.8%的学生从学校教育中学到过拒烟技巧。吸烟组的饮酒、使用毒品、伤害、旷课行为和心理问题发生率均显著高于不吸烟组。结论初中生的尝试吸烟率和吸烟率有上升趋势。吸烟行为的发生与多种不健康行为和心理问题密切相关。 | 田本淳 孟宪鹏 吕书红 钱玲 张巍 张继彬 田向阳 熊光练 严维红 张新卫 Laura Kann Leanne Riley | 2007 | 中华流行病学杂志2007，28，3： | 5 |
| 3 | Statistically Extrapolated Nowcasting of Summertime Precipitation over the Eastern Alps显示文摘This paper presents a new multiple linear regression(MLR) approach to updating the hourly, extrapolated precipitation forecasts generated by the INCA(Integrated Nowcasting through Comprehensive Analysis) system for the Eastern Alps.The generalized form of the model approximates the updated precipitation forecast as a linear response to combinations of predictors selected through a backward elimination algorithm from a pool of predictors. The predictors comprise the raw output of the extrapolated precipitation forecast, the latest radar observations, the convective analysis, and the precipitation analysis. For every MLR model, bias and distribution correction procedures are designed to further correct the systematic regression errors. Applications of the MLR models to a verification dataset containing two months of qualified samples,and to one-month gridded data, are performed and evaluated. Generally, MLR yields slight, but definite, improvements in the intensity accuracy of forecasts during the late evening to morning period, and significantly improves the forecasts for large thresholds. The structure–amplitude–location scores, used to evaluate the performance of the MLR approach,based on its simulation of morphological features, indicate that MLR typically reduces the overestimation of amplitudes and generates similar horizontal structures in precipitation patterns and slightly degraded location forecasts, when compared with the extrapolated nowcasting. | Min CHEN Benedikt BICA Lukas TCHLER Alexander KANN Yong WANG | 2017 | Advances in Atmospheric Sciences2017，34，7： | 3 |
| 4 | Enucleation and Limited Pancreatic Resection Provide Long-Term Cure for Insulinoma in Multiple Endocrine Neoplasia Type 1显示文摘 | Bartsch Detlef K Albers Max Knoop Richard Kann Peter H Fendrich Volker Waldmann Jens | 2014 | Neuroendocrinology2014，，4： | 2 |
| 5 | Imact and total proinsulin : new aspects for diagnosis and treatment of type 2 diabetes mellitus and insulin resistance 显示文摘 | Pftitzner A Kann PH Pftltzner AH | 2004 | Clin Lab2004，50，910： | 1 |
| 6 | Sexual identity, sex of sexual con- tacts,and health - risk behaviors among students in grades 9 - 12 - - youth risk behavior surveillance, selected sites, United States, 2001 - - 2009显示文摘 | Kann L Olsen EO McManus T | 2011 | MMWR Surveill Suture2011，60，7： | 1 |
| 7 | Results from the National School-Based 1991 youth risk behvior survey and progress to-ward achieving related health objectives for the nation 显示文摘 | Kann L Wrren W Collins JL | 1993 | Public Health Reports1993，，： | 1 |
| 8 | Gamma oscillations in the hippocampus require high complex I gene expression and strong functional performance of mitochondria 显示文摘 | Kann O Huchzermeyer C Kovacs R | 2011 | Brain2011，134，： | 1 |
| 9 | Overview of youth risk behavior surveillance system 显示文摘 | KOLBE LI KANN L COLLINS JL | 1993 | Pub Health Rep1993，，： | 1 |
| 10 | Youth Risk Behavior Surveillance United Statees显示文摘 | Grunbaurn JA Kann L Kinchen SA | 2004 | J Sch Health2004，74，8： | 1 |
| 11 | Vanishing lung syndrome (giant bullous emphysema): CT findings in 7 patients and a literature review显示文摘 | Sharma N Justaniah AM Kanne JP | 2009 | J Thorac Imaging2009，24，3： | 1 |
| 12 | Role of computed tomography and magnetic resonance imaging for deep venous thrombosis and pulmonary embolism 显示文摘 | Kanne JP Lalani TA | 2004 | Circulation2004，109，12： | 1 |
| 13 | Mapping of two genes for resistance to clubroot (Plasmodiophora brassicae) in a population of doubled haploid lines of Brassica oleracea by means of RFLP and AFLP markers显示文摘 | Voorrips R E Jongerius M C Kanne H J | 1997 | Theor Appl Genet1997，94，： | 1 |
| 14 | Menopause and coronary heartdisease: the framlngham study显示文摘 | Cordon T Kanne WB Hjortland Me | 1978 | Ann Intern Med1978，89，： | 1 |
| 15 | Youth risk behav2ior surveillance:United States, 2001显示文摘 | Grunbaum JA Kann L Kinchen SA | 2002 | J Sch Health2002，72，8： | 1 |
| 16 | Liquid flow in foams显示文摘 | Goldfarb I I Kann K B Shreiber I R | 1988 | Fluid Dyn ( Trans USSR Acad Scl Mech liquid Gas Ser )1988，23，2： | 1 |
| 17 | Youth risk behav- ior surveillance-United States, 2001显示文摘 | Grunbaum J A Kann L Killellen SA | 2002 | Sch Health2002，72，8： | 1 |
| 18 | Endothelin-1 plasma levels are not elevated in patients with obstructive sleep apnea显示文摘 | Grimpen G Kanne P Schulz E | 2000 | Eur Respir J2000，15，： | 1 |
| 19 | Youthrisk behavior surveillance-United States,2001显示文摘 | Grunbaum JA Kann L Kinchen SA | 2002 | MMWR Surveill Summ2002，51，4： | 1 |
| 20 | Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function 显示文摘 | Hoffmann A Kann 0 Ohlemeyer C | 2003 | J Neurosci2003，23，2： | 1 |
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