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| 1 | Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy显示文摘AIM:To analyze pituitary hormone and melatonin circadian rhythms, and to correlate hormonal alterations with clinical performance, hepatic disease severity and diagnostic tests used for the detection of hepatic encephalopathy in cirrhosis. METHODS:Twenty-six patients with cirrhosis were enrolled in the study. Thirteen patients hospitalized for systemic diseases not affecting the liver were included as controls. Liver disease severity was assessed by the Child-Pugh score. All patients underwent detailed neurological assessment, electroencephalogram (EEG), brain magnetic resonance imaging (MRI), assays of pituitary hormone, cortisol and melatonin, and complete blood chemistry evaluation. RESULTS: Pituitary hormone and melatonin circadian patterns were altered in cirrhosis patients without clinical encephalopathy. Circadian hormone alterations were different in cirrhosis patients compared with controls. Although cortisol secretion was not altered in any patient with cirrhosis, the basal cortisol levels were lowand correlated with EEG and brain MRI abnormalities. Melatonin was the only hormone associated with the severity of liver insufficiency. CONCLUSION: Abnormal pituitary hormone and melatonin circadian patterns are present in cirrhosis before the development of hepatic encephalopathy. These abnormalities may be early indicators of impending hepatic encephalopathy. Factors affecting the human biologic clock at the early stages of liver insufficiency require further study. | Dimitrios Velissaris Menelaos Karanikolas Andreas Kalogeropoulos Ekaterini Solomou Panagiotis Polychronopoulos Konstantinos Thomopoulos Chrissoula Labropoulou-Karatza | 2008 | World Journal of Gastroenterology2008,14,26: | 9 |
| 2 | Laparoscopic cholecystectomy: A report from a single center显示文摘瞄准:在 laparoscopic 胆囊炎考察并且评估我们的经验。方法:回顾的分析在从经历了 laparoscopic 胆囊炎的 1220 个病人在一个 13 年的时期(1992-2005 ) 期间收集的数据上被执行。结果:死亡率是 0% 。全面患病率是 5.08%(n = 62 ) ,与从损害产生到胆汁的树和膀胱的动脉的最严肃的复杂并发症。在 23 (1.88%) 案例,胆囊炎不能 laparoscopically 被完成,操作被变换成一个开的过程。尽管病人作为天外科案例被安排,医院停留的平均持续时间是 2.29 d,当有延长医院停留的复杂案例在计算被包括。结论:Laparoscopic 胆囊炎是有病人的有利结果的一种安全、最低限度地侵略的技术。 | Konstantinos Vagenas Stavros N Karamanakos Charalambos Spyropoulos Spyros Panagiotopoulos Menelaos Karanikolas Michalis Stavropoulos | 2006 | World Journal of Gastroenterology2006,12,24: | 5 |
| 3 | E2F-1 is overexpressed and pro-apoptotic in human hepatocellular carcinoma显示文摘 | Marina Palaiologou John Koskinas Menelaos Karanikolas Evangelia Fatourou Dina Tiniakos | 2012 | Virchows Archiv2012,,5: | 2 |
| 4 | Adjunctive anakinra in patients with active rheumatoid arthritis despite methotrexate,or lefluno-mide,or cyclosporin-A monotherapy:a 48-week,comparative,prospective study显示文摘 | Karanikolas C Charalambopoulos D Vaiopoulos G | 2008 | Rheumatology (Oxford)2008,47,9: | 1 |
| 5 | Transnasal butorphanol for the treatment of opoid-induced pruritus unresponsive to antihistamines 显示文摘 | Dunteman E Karanikolas M Filos K S | 1996 | J Pain Symptom Manage1996,12,4: | 1 |
| 6 | Acute respiratory distress syndrome:pathOphysioloogy and therapeutic options 显示文摘 | Pierrakos C Karanikolas M Scolletta S | 2011 | J Clin Med Res2011,4,1: | 1 |
| 7 | Acute respiratory distress syndrome;pathophysiology and therapeutic options显示文摘 | Pierrakos C Karanikolas M Scolletta S | 2011 | J Clin Med Res2011,4,1: | 1 |
| 8 | Professional autonomy,collaboration with physicians,and moral distress among European intensive care nurses显示文摘 | Papathanassoglou ED Karanikola MN Kalafati M | | 0,,02: | 1 |
| 9 | Comprehensive evaluat-ion of the role of EZH2in the growth,invasion,and aggression of a panel of prostate cancer cell lines显示文摘 | Karanikolas BD Figueiredo ML Wu L | 2010 | Prostate2010,70,6: | 1 |
| 10 | Polycomb group protein enhancer of zeste homolog 2 is an oncogene that promotes the neoplastic transformation of a benign prostatic epithelial cell line显示文摘 | Karanikolas B D Figueiredo M L Wu L | 2009 | Mol Cancer Res2009,7,9: | 1 |
| 11 | Professional autonomy,collaboration with physicians,and moral distress among European intensive care nurses显示文摘 | Papathanassoglou EDE Karanikola MNK Kalafati M | | 0,,2: | 1 |
| 12 | Transnasal butorphanol for the treatment of opioid-induced pruritus unresponsive to antihistamines显示文摘 | Dunteman E Karanikolas M Filos KS | 1996 | J Pain Symptom Manage1996,12,4: | 1 |
| 13 | Comprehensive e the growth, invasion, and ag gression of a panel of prostate cancer cell lines显示文摘 | Karanikolas BD Figueiredo ML valuation of the role of EZH2 in Wu L | 2010 | Prostate2010,70,6: | 1 |
| 14 | Low cost, cross-language and crossplatform information retrieval and documentation tools 显示文摘 | Nikitas N Karanikolas | 2007 | Journal of Computing and Information Technology - CIT 152007,1,: | 1 |
| 15 | Positive surgical margins and accessory pudendal artery preservation during laparoscopic radical prostatectomy 显示文摘 | Secin FP Karanikolas N Kuroiwa K | 2005 | Eur Urol2005,48,: | 1 |
| 16 | Prognostic factors and significance of the revised 6th edi- tion of the AJCC classification in patients with locally advanced nasopharyngeal carcinoma 显示文摘 | Kalogera-Fountzila A Karanikolas D Katodritis N | 2006 | Strahlenther Onkol2006,182,2: | 1 |
| 17 | Laparoscopic adrenalectomy:where do we stand now?显示文摘 | Karanikola E Tsigris C Kontzoglou K | 2010 | Tohoku J Exp Med2010,220,4: | 1 |
| 18 | The anterior layer of Denonvilliers' fascia: a common misconception in the laparoscopic prostatectomy literature显示文摘 | Secin FP Karanikolas N Gopalan A | 2007 | J Urol2007,177,2: | 1 |
| 19 | Oncological outcomes of laparoscopic radical prostatectomy : intermediate - term follow - up 显示文摘 | Secin FP Bianco FJ Karanikolas NT | 2007 | Eur Urol2007,,: | 1 |
| 20 | Cerebral oximetry and cognitive dysfunction in elderly patients undergoing surger- y for hip fractures: a prospective observational study 显示文摘 | Papadopoulos G Karanikolas M Liarmakopoulou A | 2012 | Open Orthop J2012,6,: | 1 |