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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Structural and Behavioral Synthesis for Testability Techniques显示文摘 | Chen C H Karnik T Saab D G | 1994 | IEEE Transactions on Computer-Aided Design1994，13，6： | 2 |
| 3 | DNA translocation in inorganic nanotubes 显示文摘 | FAN R KARNIK R YUE M | 2005 | Nano Lett2005，5，： | 1 |
| 4 | Type-2 fuzzy logic systems显示文摘 | Karnik N Mendel J Liang Q | 1999 | IEEE Transactions on Fuzzy Systems1999，7，6： | 1 |
| 5 | Typer-2 Fuzzy Logic Systems显示文摘 | J M Mendel Q Liang | 1999 | IEEE Trans on Fuzzy Systems1999，，7： | 1 |
| 6 | Management of pneumothorax and barotraumas: current concepts显示文摘 | Karnik AM | 2001 | Compr Ther2001，27，4： | 1 |
| 7 | Wnt signaling regulates pancreatic beta cell proliferation显示文摘 | Rulifson IC Karnik SK Heiser PW | | 0，，： | 1 |
| 8 | Duplex snnographie detection of internal jugular venous thrombosis after removal of central venous catheters 显示文摘 | KARNIK R VALENTIN A WINKLER WB | 1993 | Clin Cardiol1993，16，9： | 1 |
| 9 | Design Issues in Mobile-Agent Programming Systems显示文摘 | Karnik N M Tripathi AR | 1998 | IEEE Concurrency1998，6，3： | 1 |
| 10 | Cardiac arrest and sudden death in dialysis units显示文摘 | Karnik JA Young BS Lew NL | 2001 | Kidney Int2001，60，： | 1 |
| 11 | Antidepressant and statin interactions:a review and case report of simvastatin and nefazodone-induced rhabdomyolysis and transaminitis显示文摘 | Karnik NS Maldonado JR | | 0，，： | 1 |
| 12 | What is the right model for wireless channel interference显示文摘 | Iyer A Rosenberg C Karnik A | | 0，，05： | 1 |
| 13 | Cardiac arrest andsudden death in dialysis units显示文摘 | Karnik JA Young BS Lew NL | 2001 | Kidney Int2001，60，1： | 1 |
| 14 | Centroid of a type-2 fuzzy set显示文摘 | Karnik N N Mendel J M | 2001 | Information Sciences2001，132，14： | 1 |
| 15 | Microfluidic platform for controlled synthesis of polymeric nanoparticles 显示文摘 | Karnik R Gu F Basto P | 2008 | Nano Letters2008，8，9： | 1 |
| 16 | Type-2 fuzzy logic systems 显示文摘 | KARNIK N N MENDEL J M | 1999 | 1EEE Transactions on Fuzzy Systems1999，7，6： | 1 |
| 17 | Constitutively active homooligomeric angiotensin II type 2 receptor induces cell signaling independent of receptor conformation and ligand stimulation 显示文摘 | Miura S Karnik S S Saku K | 2005 | J Biol Chem2005，280，18： | 1 |
| 18 | Application of Type-2 Fuzzy Logic Systems to Forecasting of Time-Series显示文摘 | J M Mendel | 1999 | Information Sciences1999，120，： | 1 |
| 19 | Security in the Ajanta mobile agent system显示文摘 | KARNIK NM TRIPATHI AR | 2001 | Software Practice and Experience2001，31，4： | 1 |
| 20 | Wnt signaling regulates pancreatic 13 cell pro- liferation 显示文摘 | Rulifson IC Karnik SK HeiserPW | 2007 | Proceedings of the National Academy of Sciences2007，104，15： | 1 |
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