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| 1 | Identification of CD13,CD107a,and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-de-pendent upregulation显示文摘Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited an increased reactivity with basophils activated by anti-IgE-mediated cross-linking of the high affinity IgE receptor (FcεRI). These include antibod- ies against CD164 (WS-80160, clone N6B6 and WS-80162, clone 67D2), as well as two reagents with previously unknown specificities that were identified as CD13 (WS-80274, clone A8) and CD107a (WS-80280, clone E63-880). The activation patterns followed either the “CD203c-like” or “CD63-like” activation profile. The CD203c profile is characterized by a rapid and significant upregulation (of CD13, CD164, and CD203c), reaching maximum levels after 5- 15 min of stimulation. The phosphoinositide-3-kinase (PI3K)-specific inhibitor wortmannin inhibited the upregulation of these markers whereas 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced a rapid and FcεRI-independent upregulation within 1-2 min. In the CD63 profile, maximum upregulation (of CD63 and CD107a) was detected only after 20-40 min, and upregulation by TPA reached maximum levels after 60 min. In summary, our data identify CD13, CD107a, and CD164 as novel basophil-activation antigens. Based on time kinetics of upregulation, we hypothesize that molecules of the “CD203c group” and the “CD63 group” are linked to two different mechanisms of basophil activation. | Florian HENNERSDORF Stefan FLORIAN Andreas JAKOB Katharina BAUMGRTNER Karoline SONNECK Alfred NORDHEIM Tilo BIEDERMANN Peter VALENT Hans-Jrg BüHRING | 2005 | Cell Research2005，15，5： | 9 |
| 2 | Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development显示文摘 | KAROLINE J B ALEXANDRA L J | 2001 | Developmental Biology2001，233，： | 1 |
| 3 | Fluorescence and Absorption Spectroscopic Properties of Dipyrrometheneboron Difluoride(BODlPY) Derivatives in Liquids,Lipid Membranes,and Proteins显示文摘 | Karolin J Johansson B A Strundberg L | 1994 | J Am Chem Soc1994，116，： | 1 |
| 4 | Effect of solvent content on the separation and the energy consumption of extractive distillation columns显示文摘 | De Figueiredo M F Brito Karoline Dantas Ramos W B | 2015 | Chemical Engineering Communi- cations2015，202，9： | 1 |
| 5 | Fluores-cence and absorption spectroscopic properties of dipyr-rometheneboron difluoride(BODIPY)derivatives in liq-uids,lipid membranes,and proteins显示文摘 | Karolin J Johansson L B A Strandberg L | 1994 | J Am Chem Soc1994，116，17： | 1 |
| 6 | 查看详情显示文摘 | Karolin J Johansson B A Strandberg L | | 0，，： | 1 |
| 7 | Fluorescence and Absorption Spectroscopic Properties of Dipyrrometheneboron Difluoride(Bodipy)Derivatives in Liquids,Lipid-Membranes,and Proteins显示文摘 | Karolin J Johansson L B A Strandberg L | | 0，，17： | 1 |
| 8 | Fluorescence and absorption spectroscopic properties of dipyrrometheneboron difluoride ( BOD- IPY) derivatives in liquids, lipid membranes, and proteins 显示文摘 | Karolin J Johansson L B A Strandberg L | 1994 | J Am Chem Soc1994，116，： | 1 |
| 9 | Seconday amenorrhea after hodgkin's lymploma is influenced by age at treatment stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: a report from the german hodgkin's Iymphoma study group显示文摘 | Karolin B Kai B Thorsten R | 2005 | Journal of Clinical Oncology2005，23，30： | 1 |
| 10 | Secondary amenorrhea after hodgkins lymphoma is influenced by age at treatment,stage of disease,chemotherapy egimen,and the use of oral contraceptives during therapy:a report from the german hodgkins lymphoma study group显示文摘 | KAROLIN B KAI B THORSTREN R | 2005 | Journal of Clinical Oncology2005，23，30： | 1 |
| 11 | Phenotypic and genetic characterization of varicella-zoster virus mutants resistant to acyclovir, brivudine and/or foscarnet 显示文摘 | Karoline B Jindrich C Jonas SC | 2011 | Med Microbiol Immuuo12011，200，3： | 1 |
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