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| 1 | Molecular confocal laser endomicroscopy:A novel technique for in vivo cellular characterization of gastrointestinal lesions显示文摘While flexible endoscopy is essential for macroscopic evaluation,confocal laser endomicroscopy(CLE)has recently emerged as an endoscopic method enabling visualization at a cellular level.Two systems are currently available,one based on miniprobes that can be inserted via a conventional endoscope or via a needle guided by endoscopic ultrasound.The second system has a confocal microscope integrated into the distal part of an endoscope.By adding molecular probes like fluorescein conjugated antibodies or fluorescent peptides to this procedure(either topically or systemically administered during on-going endoscopy),a novel world of molecular evaluation opens up.The method of molecular CLE could potentially be used for estimating the expression of important receptors in carcinomas,subsequently resulting in immediate individualization of treatment regimens,but also for improving the diagnostic accuracy of endoscopic procedures by identifying otherwise invisible mucosal lesions.Furthermore,studies have shown that fluorescein labelled drugs can be used to estimate the affinity of the drug to a target organ,which probably can be correlated to the efficacy of the drug.However,several of the studies in this research field have been conducted in animal facilities or in vitro,while only a limited number of trials have actually been carried out in vivo.Therefore,safety issues still needs further evaluations.This review will present an overview of the implications and pitfalls,as well as future challenges of molecular CLE in gastrointestinal diseases. | John Gasdal Karstensen Pia Helene Klausen Adrian Saftoiu Peter Vilmann | 2014 | World Journal of Gastroenterology2014，20，24： | 6 |
| 2 | Formation, release and control of dioxins in cement kilns显示文摘 | KARSTENSEN K | 2008 | Chemosphere2008，70，： | 1 |
| 3 | et al The Effect of the Steam Temperature Fluctuations During Steady State Operation on the Remnant Life of the Super- heater Header显示文摘 | Kwon O Myers M Karstensen A D Knowles | 2006 | International Journal of Pressure Vessels and Piping2006，83，： | 1 |
| 4 | A variable-geometry power turbine for marine gas turbines 显示文摘 | KARSTENSEN K W WIGGINS J O | 1990 | ASME Journal of Turbomachinery1990，112，： | 1 |
| 5 | Burning of hazardous wastes as co-fuel in a cement kiln-does it affect the environmental quality of cement显示文摘 | KARSTENSEN K H | 1994 | Studies in Environmental Science1994，60，： | 1 |
| 6 | Environmentally sound destruction of obsolete pesticides in developing countries using cement kilns显示文摘 | KARSTENSEN K H KINH N K THANG L B | 2006 | Environmental Science & Policy2006，9，6： | 1 |
| 7 | Formation, release and control of dioxins in cement kilns 显示文摘 | Karstensen K H | 2008 | Chemosphere2008，70，： | 1 |
| 8 | Test burn with PCB-oil in a local cement kiln in Sri Lanka 显示文摘 | Karstensen K H Mubarak A M Gunadasa H N | 2010 | Chemosphere2010，78，： | 1 |
| 9 | Environmentally sound destruction of obsolete pesticides in developing countries using cement kilns 显示文摘 | Karstensen K H Kinh N K Thang B | 2006 | Environmental Science and Policy2006，9，： | 1 |
| 10 | Land change variability and human -environment dynamics in the United States great plains 显示文摘 | DRUMMOND M A AUCH R A KARSTENSEN K A SAYLER K L | 2012 | Land Use Policy2012，29，： | 1 |
| 11 | A variable-geometry power turbine for marine gas turbines 显示文摘 | KARSTENSEN K W WIGGINS J O | 1990 | ASME Journal of Turbomachinery1990，112，： | 1 |
| 12 | Formation, release and control of dioxin in cement kiln 显示文摘 | Karstensen K H | 2007 | Chemosphere2007，81，6： | 1 |
| 13 | Simultaneous endoscopic and video-assisted retroperitoneal debridement in walled-off pancreatic necrosis using a laparoscopic access platform:Two case reports显示文摘BACKGROUND Infected walled-off necrosis is a potentially life-threatening complication of necrotizing pancreatitis.While some patients can be treated by drainage alone,many patients also need evacuation of the infected debris.Central necroses in relation to the pancreatic bed are easily reached via an endoscopic transluminal approach,whereas necroses that involve the paracolic gutters and the pelvis are most efficiently treated via a percutaneous approach.Large and complex necroses may need a combination of the two methods.CASE SUMMARY Transluminal and percutaneous drainage followed by simultaneous endoscopic and modified video-assisted retroperitoneal debridement was carried out in two patients with very large(32-38 cm),infected walled-off necroses using a laparoscopic access platform.After 34 d and 86 d and a total of 9 and 14 procedures,respectively,complete regression of the walled-off necroses was achieved.The laparoscopic access platform improved both access to the cavities as well as the overview.Simultaneous transluminal and percutaneous necrosectomy are feasible with the laparoscopic access platform serving as a useful adjunctive.CONCLUSION This approach may be necessary to control infection and achieve regression in some patients with complex collections. | Lars Lindgaard Morten Laksáfoss Lauritsen Srdan Novovic Erik Feldager Hansen John Gásdal Karstensen Palle Nordblad Schmidt | 2022 | World Journal of Gastroenterology2022，28，5： | 1 |
| 14 | Parallel optical interconnec5tion for uncoded data transmission with 1 Gb/s-per-channel capacity,high dynamic range,and low power consumption显示文摘 | Holger Karstensen Christian Hanke Martin Honsberg | 1995 | Journal of Lightwave Technology1995，13，6： | 1 |
| 15 | Land change variability and human–environment dynamics in the United States Great Plains显示文摘 | Mark A. Drummond Roger F. Auch Krista A. Karstensen Kristi L. Sayler Janis L. Taylor Thomas R. Loveland | 2011 | Land Use Policy2011，，3： | 1 |
| 16 | The effect of the steam temperature fluctuations during steady state operation on the remnant life of the superheater header显示文摘 | KWON O MYERS M KARSTENSEN A D etal | 2006 | International Journal of Pressure Vessels and Piping2006，83，5： | 1 |
| 17 | Formation,release and control of dioxins in cement kilns显示文摘 | KARSTENSEN K H | 2008 | Chemosphere2008，70，： | 1 |
| 18 | A ner statistical local criterion for cleavage fracture in steel, part Ⅱ: application to an offshore structural steel显示文摘 | Bordet S R Karstensen A D Knowles D M | 2005 | Engineering Fracture Mechanics2005，72，： | 1 |
| 19 | A Variable Geometry Power Turbine for Marine Gas Turbines显示文摘 | Karstensen K W Wiggins J O | 1990 | ASME Jour- nal ofTurbomachinery1990，112，： | 1 |
| 20 | Formation, release and control of dioxins in cement kilns 显示文摘 | KARSTENSEN K H | 2008 | Chemosphere2008，70，4： | 1 |
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