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| 1 | Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome显示文摘Clinical studies have indicated that circulating bile acid(BA) concentrations increase following bariatric surgery, especially following malabsorptive procedures such as Roux-en-Y gastric bypasses(RYGB). Moreover, total circulating BA concentrations in patients following RYGB are positively correlated with serum glucagonlike peptide-1 concentrations and inversely correlated with postprandial glucose concentrations. Overall, these data suggest that the increased circulating BA concentrations following bariatric surgery- independently of calorie restriction and body-weight loss- could contribute, at least in part, to improvements in insulin sensitivity, incretin hormone secretion, and postprandial glycemia, leading to the remission of type-2 diabetes(T2DM). In humans, the primary and secondary BA pool size is dependent on the rate of biosynthesis and the enterohepatic circulation of BAs, as well as on the gut microbiota, which play a crucial role in BA biotransformation. Moreover, BAs and gut microbiota are closely integrated and affect each other. Thus, the alterations in bile flow that result from anatomical changes caused by bariatric surgery and changes in gutmicrobiome may influence circulating BA concentrations and could subsequently contribute to T2 DM remission following RYGB. Research data coming largely from animal and cell culture models suggest that BAs can contribute, via nuclear farnezoid X receptor(FXR) and membrane G-protein-receptor(TGR-5), to beneficial effects on glucose metabolism. It is therefore likely that FXR, TGR-5, and BAs play a similar role in glucose metabolism following bariatric surgery in humans. The objective of this review is to discuss in detail the results of published studies that show how bariatric surgery affects glucose metabolism and subsequently T2 DM remission. | Lukasz Kaska Tomasz Sledzinski Agnieszka Chomiczewska Agnieszka Dettlaff-Pokora Julian Swierczynski | 2016 | World Journal of Gastroenterology2016，22，39： | 11 |
| 2 | Effect of NCPB and VSPL on pain and quality of life in chronic pancreatitis patients显示文摘AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) patients.METHODS: Forty-eight small duct CP patients were treated invasively with NCPB (n = 30) or VSPL (n = 18) in two non-randomized, prospective, case-controlled protocols due to chronic pain syndrome, and compared to a control group who were treated conservatively (n = 32). Visual analog scales were used to assess pain and opioid consumption rate was evaluated. In addition, the quality of life was measured using QLQ C-30 for NCPB and FACIT for VSPL.Although both questionnaires covered similar problems,they could not be compared directly one with another.Therefore, the studies were compared by meta-analysis methodology.RESULTS: Both procedures resulted in a significant positive effect on pain of CP patients. Opioids were withdrawn totally in 47.0% of NCPB and 36.4% of VSPL patients,and reduced in 53.0% and 45.4% of the respective patient groups. No reduction in opioid usage was observed in the control group. In addition, fatigue and emotional well-being showed improvements. Finally, NCPB demonstrated stronger positive effects on social support, which might possibly be attributed to earlier presentation of patients treated with NCPB.CONCLUSION: Both invasive pain treatment methods are effective in CP patients with chronic pain. | Andrzej Basinski Tomasz Stefaniak Ad Vingerhoets Wojciech Makarewicz Lukasz Kaska Aleksander Stanek Andrzej J.Lachinski Zbigniew Sledzinski | 2005 | World Journal of Gastroenterology2005，11，32： | 10 |
| 3 | Experimental investigation of thermal performance of a solar assisted heat pump system with an energy storage 显示文摘 | Yumrutas R Kaska O | 2004 | International Journal of Energy Research2004，28，： | 1 |
| 4 | The impact and safety of preoperative oral or intravenous carbohydrate administration versus fasting in colorectal surgery--a randomized controlled trial显示文摘 | Kaska M Grosmanová T Havel E | 2010 | Wien Klin Wochenschr2010，122，12： | 1 |
| 5 | Early re- suits of Rouen Ygastric bypass on regulation of diabetes type 2 in patients with BMI above and below 35 kg/m2 显示文摘 | Proczko-Markuszewska M Stefaniak T Kaska L | 2011 | Pol Przegl Chir2011，83，2： | 1 |
| 6 | Determining the heavy metal pollution in Denizli (Turkey) by using Robinio pseudo-acacia L.显示文摘 | Ali ?elik Asl?han A. Kartal Abdullah Akdo?an Yakup Kaska | 2004 | Environment International2004，，1： | 1 |
| 7 | Development of structures of intestinal an- astomosis and the actual state of their options 显示文摘 | Blazej Paral J Kaska | 2015 | Rozhl Chit2015，94，8： | 1 |
| 8 | Roux-en-Y gastric bypass in dialysed morbidly obese patients as a preparation for a kidney transplantation: case series显示文摘 | Proczko M Kaska L Kobiela J | 2013 | Wideochir Irme Tech Maloinwazyjne2013，8，2： | 1 |
| 9 | Experimental Investigation of Thermal Performance of A Solar Assisted Heat Pump System with An Energy Storage 显示文摘 | Yurnrutas R Kaska O | 2004 | Int J Energy Res2004，28，： | 1 |
| 10 | Experimental Investigation of Thermal Performance of a Solar Assisted Heat Pump System with an Energy Storage显示文摘 | Yumrutas R Kaska O | 2004 | International Journal of Energy Research2004，28，2： | 1 |
| 11 | The impact and safety of preoperative oral or intravenous carbohydrate ad- ministration versus fasting in colorectal surgery--a ran- domized controlled trial显示文摘 | Kaska M Grosmanovd T Havel E | 2010 | Wien Klin Wochenschr2010，122，12： | 1 |
| 12 | Embryological development of sea turtles ( Chelonia mydas,Caretta caretta) in the Mediterranean 显示文摘 | KASKA Y DOWNIE R | 1999 | Zoology in the Middle East1999，19，： | 1 |
| 13 | Early results of Roux-en-Y gastric bypass on regulation of diabetes type 2 in patients with BMI above and below 35 kg/m2显示文摘 | Proczko-Markuszewska M Stefaniak T Kaska L | | 0，，： | 1 |
| 14 | Pathomorphological changes in microcirculation of pancreas during experimental acute pancreatitis显示文摘 | Kaska M Pospísilová B Slízová D | 2000 | Hepatogastroenterology2000，47，36： | 1 |
| 15 | Experimental investigation of thermal performance of a solar assisted heat pump system with an energy storage 显示文摘 | YUMRUTAS RECEP KASKA ONDER | 2004 | International journal of energy research2004，，28： | 1 |
| 16 | The impact and safety of preoperative oral or intravenous carbohydrate administration versus fasting in colorectal surgery-a randomized controlled trial显示文摘 | Kaska M Grosmanová T Havel E | 2010 | Wien Klin Wochenschr2010，122，12： | 1 |
| 17 | The impact and safety of preoperative oral or intravenous carbohydrate administration versus fasting in eolorectal surgery-a randomized controlled trial 显示文摘 | Kaska M Grosmanov(t T Havel E | 2010 | Wien Klin Wochenschr2010，122，12： | 1 |
| 18 | The impact and safety of preoperative oral or intravenous carbohydrate administration versus fasting in colorectal surgery -a randomized controlled trial 显示文摘 | Kaska M Grosmanovat T Havel E | 2010 | Wien Klin Wochensehr2010，122，12： | 1 |
| 19 | Preparation of patients for operation with per-oral intake on the day of the planned surgery显示文摘 | Kaska M Grosmanova T Havel E | 2006 | Rozhl Chir2006，85，11： | 1 |
| 20 | Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice显示文摘 | Copple BL Kaska S Wending C | 2012 | J Pharmacol Exp Ther2012，341，2： | 1 |
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