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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Examining 'core-periphery' relationships in a global city-region: The case of london and south east england 显示文摘 | Kathy P | 2008 | Regional Studies2008，42，8： | 1 |
| 3 | Characterization and cloning of GP50, a Taeaia solium antigen diagnostic for cysticercosis 显示文摘 | Kathy H Sowmya P Ryan M | 2004 | Molecular Biochemical Parasitology2004，133，： | 1 |
| 4 | Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism显示文摘 | She P Shiota M Kathy D | 2000 | Molecular and Cellular Biology2000，20，17： | 1 |
| 5 | The ethics of carbon neutrality: A critical examination of voluntary carbon offset providers显示文摘 | Dhanda K Kathy Hartman Laura P | 2011 | Journal of Business Ethics2011，100，1： | 1 |
| 6 | Disruption of FEM1C-W gene in zebra finch evolutionary insights on avian ZW genes 显示文摘 | Yuichiro I Kathy K Arthur P A | 2009 | Chromosoma2009，118，3： | 1 |
| 7 | Rehabilitation starts in the in- tensive care unit 显示文摘 | Nathan R Kathy P Daniel C | 2012 | Crit Care Nurs Q2012，35，3： | 1 |
| 8 | Bone do- wels in anterior lumbar interbody fusion显示文摘 | Lekovic Gregory P Han Patrick P Kenny Kathy J | 2007 | J Spinal Disord Tech2007，20，： | 1 |
| 9 | Unintentional Hypothermia: Implications for Perianesthesia Nurses显示文摘 | Shari M B Mary W Kathy P | 2015 | Journal of PeriAnesthesia Nursing2015，1，4： | 1 |
| 10 | In- terferon-tau suppresses prostaglandin F2a secretion independently of the Mitogen-activated protein kinase and nuclear factor κB pathway显示文摘 | JAMES K P RUEDA B R KATHY J A | 2001 | Biol Reprod2001，64，： | 1 |
| 11 | Quantitation of kappa and Lamba 显示文摘 | Robert P Kathy h Judyc | 1986 | Chinchem1986，32，6： | 1 |
| 12 | Synthesis and characterization of anisometric cobalt nanoclusters显示文摘 | Charles P Gibson Kathy J Putzer | 1995 | Science1995，267，： | 1 |
| 13 | Semibatch absorption and regeneration studies for CO2 capture by aqueous ammonia显示文摘 | YEH JAMES T RESNIK KEVIN P KATHY RYGLE | 2005 | Fuel Processing Technology2005，86，15： | 1 |
| 14 | Semi-batch absorption and regeneration studies for CO2 capture by aqueous ammonia显示文摘 | James T Y Kevin P R Kathy R | 2005 | Fuel Processing Technology2005，86，1415： | 1 |
| 15 | Hostile Attributional Ten- dencies in Maltreated Children显示文摘 | Joseph M P Kathy G | 2003 | Journal of Ab- normal Child Psychology2003，31，3： | 1 |
| 16 | Sleep in infants and young children( part one) : Normal sleep 显示文摘 | Katherine F D Kathy P P Montgomery G L | 2004 | Journal of Pediatric Health Care2004，18，2： | 1 |
| 17 | Evidence for carbon saturation in a highly structured and organic-matter-rich soil显示文摘 | Chung H Kathie J N Alain P | 2010 | Soil Science Society of America Journal2010，74，1： | 1 |
| 18 | Improving infection prevention and control显示文摘 | Kathy P | 2009 | Dental Nursing2009，5，4： | 1 |
| 19 | Partneringin construction:critical study of problems for implementation显示文摘 | Albert P C Chan Daniel W M Chan Kathy S K Ho | 2003 | Journal of Management in Engineering2003，21，7： | 1 |
| 20 | Agri-environmental policies in the EU and United States A comparison显示文摘 | Kathy B Stephen P Gordon R | | 0，，04： | 1 |
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