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| 1 | Peroxisome proliferator-activated receptor gamma as a therapeutic target for hepatocellular carcinoma:Experimental and clinical scenarios显示文摘Hepatocellular carcinoma(HCC)is the most common type of liver cancer worldwide.Viral hepatitis is a significant risk factor for HCC,although metabolic syndrome and diabetes are more frequently associated with the HCC.With increasing prevalence,there is expected to be>1 million cases annually by 2025.Therefore,there is an urgent need to establish potential therapeutic targets to cure this disease.Peroxisome-proliferator-activated receptor gamma(PPARγ)is a ligand-activated transcription factor that plays a crucial role in the pathophysiology of HCC.Many synthetic agonists of PPARγsuppress HCC in experimental studies and clinical trials.These synthetic agonists have shown promising results by inducing cell cycle arrest and apoptosis in HCC cells and preventing the invasion and metastasis of HCC.However,some synthetic agonists also pose severe side effects in addition to their therapeutic efficacy.Thus natural PPARγagonists can be an alternative to exploit this potential target for HCC treatment.In this review,the regulatory role of PPARγin the pathogenesis of HCC is elucidated.Furthermore,the experimental and clinical scenario of both synthetic and natural PPARγagonists against HCC is discussed.Most of the available literature advocates PPARγas a potential therapeutic target for the treatment of HCC. | Swati Katoch Vinesh Sharma Vikram Patial | 2022 | World Journal of Gastroenterology2022，28，28： | 2 |
| 2 | Sustainability Assessment and Ranking of Run of the River(RoR) Hydropower Projects Using Analytical Hierarchy Process(AHP):A Study from Western Himalayan Region of India显示文摘In the present scenario,tapping the unutilised hydropower potential is one of the highest priorities in developing countries of the world.Special emphasis is being imparted to run of the river(RoR)mode of power generation.However,the governments are now facing the dilemma whether to promote small hydropower projects(SHPs) or encourage large hydropower projects(LHPs).RoR large hydropower projects result into large scale cutting of mountains for constructing tunnels and access roads,generation of huge quantity of muck and large scale impact on flora and fauna due to diversion of rivers/streams.On the other hand,though SHPs are claimed to be greener and more sustainable by a section of researchers and energy planners but,they will be required to be set up in large number to generate equivalent amount of electricity.The aim of this study is to rank the most sustainable installed capacity range of RoR hydropower projects.To achieve this aim,the study proposes the use of quite popular multi-criteria decision making(MCDM)method of Operation Research named Analytical Hierarchy Process.A case study has been presented from Himachal Pradesh,a hydro rich state located in the western Himalayan region.As per sustainability assessment carried out in this study,hydropower projects in the capacity range 1 to 5 MW have been ranked to be the most sustainable. | Deepak KUMAR Surjit Singh KATOCH | 2015 | Journal of Mountain Science2015，12，5： | 2 |
| 3 | Epidemiological observation on goatpox in Himachal Pradesh 显示文摘 | BATTA M K KATOCH R C SHARMA M T | 1999 | Indian Vet J1999，76，8： | 1 |
| 4 | Determination of drug susceptibility patterns and genotypes of M yeobacterium tubercu losis isolates from Kanpur district, North India显示文摘 | Purwar S Chaudhari S Katoch V | 2011 | Infect Genet Evol2011，11，2： | 1 |
| 5 | Synthesis of poly?aniline/Tit), hybrid nanoplates via a sol-gel chemical method显示文摘 | Katoch A Burkhart M Hwang T et a1 | 2012 | Chern Eng J2012，192，： | 1 |
| 6 | Synthesis of hollow silica fibers with porous walls by coaxial electrospinning method显示文摘 | Akash Katoch Sang Sub Kim | 2012 | J Am Ceram Soc2012，95，2： | 1 |
| 7 | Ca2+-and protein kinase Cdependent stimulation of mitogen-activated protein kinase in detergent-skin vascular smooth muscle显示文摘 | Katoch S S Su X Moreland R S | 1999 | J Cell Physiol1999，179，2： | 1 |
| 8 | Evaluation of 18F -2 -deoxy - 2 - fluoro - D - glucose positron emission tomography forgastric cancer显示文摘 | Mochiki E Kuwano H Katoch H | 2004 | World J Surg2004，28，3： | 1 |
| 9 | Differential B-cell responses are induced by Mycobacteri- um tuberculosis PE antigens Rvll69c,RvO978c,and Rvl818c显示文摘 | YEDDULA NARAYANA BEENU JOSHI VM KATOCH | 2007 | Clin Vaccine Immunol2007，14，10： | 1 |
| 10 | Microarray analysisof efflux pump genes in multidrug-resistant Mycobacterium tuber-culosis during stress induced by common anti-tuberculous drugs显示文摘 | Gupta A_K Katoch VM Chauhan DS | 2010 | Microb Drug Resist2010，16，： | 1 |
| 11 | Rapid identifi- cation of mycobaeteria by gene amplification restriction analy- sis technique targeting 16S-23S ribosomal RNA internal tran- scribed spacer & flanking region显示文摘 | Katoch V M Parashar D Chauhan D S etal | 2007 | Indian J Med Res2007，125，2： | 1 |
| 12 | RNAi for Insect Control: Current Perspective and Future Challenges显示文摘 | Rajan Katoch Amit Sethi Neelam Thakur Larry L. Murdock | 2013 | Applied Biochemistry and Biotechnology2013，，4： | 1 |
| 13 | Infections due to non-tuberculous mycobacteria 显示文摘 | Katoch V M | 2004 | Indian J Med Res2004，120，： | 1 |
| 14 | Animal models of tuberculosis显示文摘 | Gupta UD Katoch VM | 2005 | Tu-berculosis2005，85，56： | 1 |
| 15 | Current status of TB vaccines显示文摘 | Umesh Datta Gupta Vishwa Mohan Katoch David N. McMurray | 2007 | Vaccine2007，，19： | 1 |
| 16 | Newer diagnostic techniques for tuberculosis显示文摘 | Katoch V M | 2004 | Indian J Med Res2004，，120： | 1 |
| 17 | 2D-QSAR model development and analysis on variant groups of anti-tuberculosis drugs显示文摘 | Dwivedi N Mishra BN Katoch VM | 2011 | Bioinformation2011，7，2： | 1 |
| 18 | Newerdiagnostic techniques for tuberculosis 显示文摘 | Katoch VM | 2004 | Indian J Med Res2004，120，4： | 1 |
| 19 | Animal models of tuberculosis for vac-cine development显示文摘 | Gupta UD Katoch VM | 2009 | Indian J Med Res2009，129，1： | 1 |
| 20 | Apparent accommodation(pseudoaccommodation) on pseeudophakia显示文摘 | Sugitani Y Komori R Katoch R | 1979 | Folia Ophthalmol Jpn1979，30，3： | 1 |
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