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| 1 | Host genetic factors affecting hepatitis B infection outcomes:Insights from genome-wide association studies显示文摘The clinical outcome of hepatitis B virus(HBV) infection depends on the success or failure of the immune responses to HBV,and varies widely among individuals,ranging from asymptomatic self-limited infection,inactive carrier state,chronic hepatitis,cirrhosis,hepatocellular carcinoma,to liver failure,depending on the success or failure of immune response to HBV.Genome-wide association studies(GWAS) identified key genetic factors influencing the pathogenesis of HBV-related traits.In this review,we discuss GWAS for persistence of HBV infection,antibody response to hepatitis B vaccine,and HBV-related advanced liver diseases.HBV persistence is associated with multiple genes with diverse roles in immune mechanisms.The strongest associations are found within the classical human leukocyte antigen(HLA) genes,highlighting the central role of antigen presentation in the immune response to HBV.Associated variants affect both epitope binding specificities and expression levels of HLA molecules.Several other susceptibility genes regulate the magnitude of adaptive immune responses,determining immunity vs tolerance.HBV persistence and nonresponse to vaccine share the same risk variants,implying overlapping genetic bases.On the other hand,the risk variants for HBV-related advanced liver diseases are largely different,suggesting different host-virus dynamics in acute vs chronic HBV infections.The findings of these GWAS are likely to pave the way for developing more effective preventive and therapeutic interventions by personalizing the management of HBV infection. | Izzet Mehmet Akcay Seyma Katrinli Kamil Ozdil Gizem Dinler Doganay Levent Doganay | 2018 | World Journal of Gastroenterology2018，24，30： | 6 |
| 2 | Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B显示文摘AIM: To investigate the effect of human leukocyte antigen(HLA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.METHODS: Patient records at a single institution's hepatology clinic were reviewed. Demographic data, laboratory results, endoscopy results, virological parameters, biopsy scores and treatment statuses were recorded. In total, 355 patients were eligible for thestudy, of whom 226(63.7%) were male. Overall, 82(23.1%) were hepatitis B early antigen(HBeAg) positive, 87(24.5%) had cirrhosis, and 66(18.6%) had inactive disease. The presence of DQB1 and DRB1 alleles was determined by polymerase chain reaction with sequence-specific primers. The distribution of the genotyped alleles among patients with cirrhosis and patients with chronic active hepatitis was analyzed.RESULTS: The most frequent HLA DQB1 allele was DQB1*03:01(48.2%), and the most frequent HLA DRB1 allele was DRB1*13/14(51.8%). DQB1*05:01 was more frequent in patients with active disease than in inactive patients(27% vs 9.1%; P = 0.002, Pc = 0.026). DRB1*07 was rare in patients with cirrhosis compared with non-cirrhotics(3.4% vs 16%; P = 0.002, Pc = 0.022). Older age(P < 0.001) and male gender(P = 0.008) were the other factors that affected the presence of cirrhosis. In a multivariate logistic regression analysis, DRB1*07 remained a significant negative predictor of cirrhosis(P = 0.015). A bioinformatics analysis revealed that a polymorphic amino acid sequence in DRB1*07 may alter interaction with the T-cell recognition site.CONCLUSION: This study demonstrates that HLA alleles may influence cirrhosis development and disease activity in Turkish chronic hepatitis B patients. | Levent Doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer Gizem Dinler Doganay | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 3 | The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs显示文摘 | Levent Doganay Ilyas Tuncer Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Gizem Dinler | 2012 | Clinics and Research in Hepatology and Gastroenterology2012，，： | 1 |
| 4 | Leader-member Exchange,Organizational Identification and the Mediating Role of Job Involvement for Nurses 显示文摘 | Alev Katrinli Gulem Atabay Gonca Gunay | 2008 | Journal of Advance Nursing2008，64，4： | 1 |
| 5 | Leadermember exchange, organizational identification and the mediating role of job involvement for nurses显示文摘 | KATRINLI A ATABAY G GUNAY G | 2008 | The Journal of Advanced Nursing2008，64，4： | 1 |
| 6 | The effects of managerial coaching behaviors on the employees' perception of job satisfaction, organisational commitment, and job performance: Case study on insurance industry in Turkey显示文摘 | Kalkavan S Katrinli A | 2014 | Procedia-Social and Behavioral Sciences2014，150，： | 1 |
| 7 | Leader - member exchange, organiza-tional identification and the mediatingrole of job involvement for nurses显示文摘 | Katrinli A Atabay G Gunay G | 2008 | Journal of Advanced Nursing2008，64，4： | 1 |
| 8 | Role of cultural sensitivity on creativity of academic expatriates: The moderating effect of culture 显示文摘 | Katrinli A Penbek S | 2010 | African Journal of Business Management2010，4，5： | 1 |
| 9 | Gender stereotyping in the accounting profession in Turkey显示文摘 | Katrinli Alev Gunay Gonca Erdener Acar Ece Zengin Karaibrahimoglu Yasemin | 2010 | Journal of Modern Accounting and Auditing2010，6，4： | 0 |
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