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| 1 | Rheumatic manifestations of inflammatory bowel disease显示文摘This article reviews the literature concerning rheu-matic manifestations of inflammatory bowel disease (IBD),including common immune-mediated pathways,frequency,clinical course and therapy. Musculoskel-etal complications are frequent and well-recognized manifestations in IBD,and affect up to 33% of pa-tients with IBD. The strong link between the bowel and the osteo-articular system is suggested by many clinical and experimental observations,notably in HLA-B27 transgenic rats. The autoimmune pathogenic mechanisms shared by IBD and spondyloarthropathies include genetic susceptibility to abnormal antigen pre-sentation,aberrant recognition of self,the presence of autoantibodies against specific antigens shared by the colon and other extra-colonic tissues,and increased intestinal permeability. The response against microor-ganisms may have an important role through molecular mimicry and other mechanisms. Rheumatic mani-festations of IBD have been divided into peripheral arthritis,and axial involvement,including sacroiliitis,with or without spondylitis,similar to idiopathic anky-losing spondylitis. Other periarticular features can oc-cur,including enthesopathy,tendonitis,clubbing,peri-ostitis,and granulomatous lesions of joints and bones.Osteoporosis and osteomalacia secondary to IBD and iatrogenic complications can also occur. The manage-ment of the rheumatic manifestations of IBD consists of physical therapy in combination with local injection of corticosteroids and nonsteroidal anti-inflammatory drugs; caution is in order however,because of their possible harmful effects on intestinal integrity,perme-ability,and even on gut inflammation. Sulfasalazine,methotrexate,azathioprine,cyclosporine and lefluno-mide should be used for selected indications. In some cases,tumor necrosis factor-α blocking agents should be considered as first-line therapy. | Tatiana Sofía Rodríguez-Reyna Cynthia Martínez-Reyes Jesús Kazúo Yamamoto-Furusho | 2009 | World Journal of Gastroenterology2009，15，44： | 11 |
| 2 | Temporal Structures of the North Atlantic Oscillation and Its Impact on the Regional Climate Variability显示文摘在这研究,北方 AtlanticOscillation (NAO ) 和它地区性的气候可变性上的影响的变化的时间的结构用各种各样的数据集被分析。结果证明在大西洋区域的堵住的形成对 NAO 的阶段敏感。堵住天的百分之 57 更多的冬季与 NAO 的积极阶段相比在否定阶段期间被观察。只要 6 天的长度在 NAO 的积极阶段期间观察了,在否定阶段期间堵住的平均长度将近是大约 11 天,它是两次。在堵住有在表面气温异例的分发的变化的 reassociated,到大程度,它是由 NAO 的阶段决定了的频率和坚持的 NAO 相关的差别。地区性的云量的分发对 NAO 的阶段也敏感。为否定阶段,云量是重要的,在在热带的对流地区和在中间的纬度的少得多阴沉的正异常。要不是 NAO 的积极阶段,云量在 themid 纬度暴风雨轨道区域是高得多的。在整个大西洋区域,云量随表面气温的增加显示出减少。这些结果建议可以在大西洋区域在云量和表面气温之间有否定反馈。 | 黄建平 季明霞 Kaz HIGUCHI Amir SHABBAR | 2006 | Advances in Atmospheric Sciences2006，23，1： | 7 |
| 3 | Anal intraepithelial neoplasia: A review of diagnosis and management显示文摘Anal intraepithelial neoplasia(AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. Although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the United States, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer. Risk factors for AIN and anal cancer consist of clinical factors and behaviors that are associated with the acquisition and persistence of human papilloma virus(HPV) infection. The strongest HPV-associated risk factors are HIV infection, receptive anal intercourse, and high risk sexual behavior. A history of HPVmediated genital cancer, which suggests infection with an oncogenic HPV strain, is another risk factor for AIN/anal cancer. Because progression of AIN to anal cancer is known to occur in some individuals over several years, screening for AIN and early anal cancer, as well as treatment of advanced AIN lesions, is reasonable in certain high-risk populations. Although randomized controlled trials evaluating screening and treatment outcomes are lacking, experts support routine screening for AIN in high risk populations. Screening is performed using anal cytological exams, similar to those performed in cervical cancer screening programs, along with direct tissue evaluation and biopsy via high resolution anoscopy. AIN can be treated using topical therapies such as imiquimod, 5-flurouracil, and trichloroacetic acid, as well as ablative therapies such as electrocautery and laser therapy. Reductions in AIN and anal cancer rates have been shown in studies where high-risk populations were vaccinated against the oncogenic strains of HPV. Currently, the CDC recommends both high-risk and average-risk populations be vaccinated against HPV infection using the quadrivalent or nonavalent vaccines. It is important for clinicians to be familiar with AIN and the role of HPV vaccination, particularly in high risk populations. | Joseph R Roberts Lacey L Siekas Andrew M Kaz | 2017 | World Journal of Gastrointestinal Oncology2017，9，2： | 3 |
| 4 | Eye-safe output from noncritically phase-matched parametric oscillators 显示文摘 | Marshall L R Kaz A | 1993 | Journal of the Optical Society of America B1993，10，9： | 1 |
| 5 | Strategic R&D policy and appropriabili- ty显示文摘 | KAZ M OHNO Y | 1997 | Journal of International Economies1997，，42： | 1 |
| 6 | Chest radiographic and CT findings in novel swine-origin influenza A (H1N1) virus (S-OIV) infection显示文摘 | Agarwal PP Cinti S Kaz erooni EA | 2009 | AJR2009，193，6： | 1 |
| 7 | Imageable fluorescent me- tastasis resulting in transgenic GFP mice orthotopically implanted with human-patient primary pancreatic cancer specimens显示文摘 | Suetsugu A Kaz M Fleming J | 2012 | Anti- cancer Res2012，32，4： | 1 |
| 8 | Eye - safe output from noncritically phase- matched parametric oscillators显示文摘 | Larry R. Marshall A. Kaz | | 0，，： | 1 |
| 9 | Correlation of harris mats,physical exam,pic-tures,and radiographic measurements in adult flatfoot deformity显示文摘 | Coughlin MJ Kaz A | 2009 | Foot Ankle Int2009，7，： | 1 |
| 10 | Uncertainty,spillovers and sooperation R&D显示文摘 | KAZ M YUKA O | 2002 | Intrnational Journal of Industrial Organisation2002，，20： | 1 |
| 11 | Combined electrochemical and surface analysis investigation of degradation processes in polymer electrolyte membrane fuel cells 显示文摘 | SCHULZE M WAGNER N KAZ T | 2007 | Electrochimica Acta2007，52，： | 1 |
| 12 | Study of membrane elec-trode assemblies for direct methanol fuel cells 显示文摘 | Gulzow E Kaz T Reissner R | 2005 | Power Sources2005，105，2： | 1 |
| 13 | 显示文摘 | Kaz'mina OIu Ole?chik IV Zeziulia TN | 2002 | Zh Nevrol Psikhiatr Im S S Korsakova2002，102，9： | 1 |
| 14 | Cell number, cell growth, antheridio- genesis, and eallose amount is reduced and atrophy induced by deoxyglueose in Anemia phyllitidis gametophytes 显示文摘 | KAZ'MIERCZAK A 2008 | 2008 | Plant Cell Rep2008，27，： | 1 |
| 15 | Combined electrochemical and surface analysis investigation of degradation processes in polymer electrolyte membrane fuel cells显示文摘 | Schulze M Wagner N Kaz T | 2007 | Electrochimica Acta2007，52，6： | 1 |
| 16 | The relationship between the wintertime North Atlantic Oscillation and blocking episodes in the North Atlantic显示文摘 | SHABBAR A HUANG J KAZ H | 2001 | International Journal of Climatology2001，21，3： | 1 |
| 17 | Application of Nonparametric Density Estimation to Computation of Flood Magnitude/frequency显示文摘 | Charles L Kaz A | 1987 | Stochastic Hydrology1987，，： | 1 |
| 18 | Uncertainty, spillovers,and cooperative R&D 显示文摘 | Kaz Miyagiwa Yuka Ohno | 2002 | International Journal of IndustrialOrganization2002，，20： | 1 |
| 19 | KATP channel interaction with adenine nucleotides显示文摘 | YAS K KAZ U | 2005 | J Mol Cell Cardiol2005，38，： | 1 |
| 20 | Physical ageing of the contact line on colloidal particles at liquid interfaces 显示文摘 | KAZ D M MCGORTY R MANI M | 2012 | Nat Mater2012，11，2： | 1 |
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