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| 1 | Antiangiogenic therapy for portal hypertension in liver cirrhosis: Current progress and perspectives显示文摘Developing medicines for hemodynamic disorders that are characteristic of cirrhosis of the liver is a relevant problem in modern hepatology. The increase in hepatic vascular resistance to portal blood flow and subsequent hyperdynamic circulation underlie portal hypertension(PH) and promote its progression, despite the formation of portosystemic collaterals. Angiogenesis and vascular bed restructurization play an important role in PH pathogenesis as well. In this regard, strategic directions in the therapy for PH in cirrhosis include selectively decreasing hepatic vascular resistance while preserving or increasing portal blood flow, and correcting hyperdynamic circulation and pathological angiogenesis. The aim of this review is to describe the mechanisms of angiogenesis in PH and the methods of antiangiogenic therapy. The Pub Med database, the Google Scholar retrieval system, and the reference lists from related articles were used to search for relevant publications. Articles corresponding to the aim of the review were selected for 2000-2017 using the keywords: 'liver cirrhosis', 'portal hypertension', 'pathogenesis', 'angiogenesis', and 'antiangiogenic therapy'. Antiangiogenic therapy for PH was the inclusion criterion. In this review, we have described angiogenesis inhibitors and their mechanism of action in relation to PH. Although most of them were studie donly in animal experiments, this selective therapy for abnormally growing newly formed vessels is pathogenetically reasonable to treat PH and associated complications. | Dmitry Victorovich Garbuzenko Nikolay Olegovich Arefyev Evgeniy Leonidovich Kazachkov | 2018 | World Journal of Gastroenterology2018，24，33： | 13 |
| 2 | The mul- tigene family of lysophosphatidate acyltransferase (LPAT)-related enzymes in Ricinus communis:cloning and molecular characterization of two LPAT genes that are expressed in castor seeds 显示文摘 | Arroyo-Caro J M Chileh T Kazachkov M | 2013 | Plant Science2013，，： | 1 |
| 3 | Release of cytokines by human nasal epithelial cells and peripheral blood mononuclear cells infected with Mycoplasma pneumoniae显示文摘 | Kazachkov MY Hu PC Carson JL | 2002 | Exp Biol Med (Maywood)2002，227，5： | 1 |
| 4 | The third harmonic in the Russia-Finland DC interconnection 显示文摘 | KAZACHKOV Y BOYARSKY A KRAICHIK Y | 1994 | IEEE Trans on Power Delivery1994，9，4： | 1 |
| 5 | Gas sensing properties of In2O3 and Au-doped films for detecting carbon monoxide in air 显示文摘 | Belysheva T V Kazachkov E A Gutman E E | 2001 | Anal Chem2001，56，67： | 1 |
| 6 | Release of cytokines by human nasal epithelial cells and peripheral blood mononuclear cells infected with Mycoplasma pneumoniae显示文摘 | Kazachkov MY Hu PC Carson JL | | 0，，： | 1 |
| 7 | Release of cytokines by human nasal epithelial cells and peripheral blood mononuclear cells infected with mycoplasma pneumoniae显示文摘 | Kazachkov MY Carson JL Murphy PC | 2002 | Exp Biol Med2002，227，5： | 1 |
| 8 | Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine 显示文摘 | Gubisne-Haberle D Hill W Kazachkov M Richardson JS Yu PH | 2004 | J Pharrnacol Exp Ther2004，310，： | 1 |
| 9 | Effect of aldehydes derived from oxidative deamination and oxidative stress on beta-amyloid aggregation;pathological implications to Alzheimer's disease显示文摘 | Chen K Kazachkov M Yu PH | 2007 | J Neural Transm2007，114，： | 1 |
| 10 | Gas sensing properties of In2O3 and Au-doped films for detecting carbon monoxide in air 显示文摘 | Belysheva T V Kazachkov E A Gutman E E | 2001 | J Anal Chem2001，56，7： | 1 |
| 11 | Modeling wind farms for power system stability studies显示文摘 | Kazachkov Y A Feltes J W Zavadil R | 2003 | IEEE Trans on Power Systems2003，6，3： | 1 |
| 12 | Effect of aldehydes derived from oxidative deamination and oxidative stress on beta-amyloid aggregation :pathological implications to Alzheimer 's disease 显示文摘 | Chen K Kazachkov M Yu PH | 2007 | J Neural Transm2007，114，6： | 1 |
| 13 | Effect of aldehydes derived from oxidative deamination and oxidative stress on beta-amyloid aggregation; pathological implications to Alzheimer's disease显示文摘 | Chen K Kazachkov M Yu PH | 2007 | J Neural Transm2007，114，： | 1 |
| 14 | An analytical model on the instability of thin film flow dynamics in a micro-gap channel显示文摘 | Yang Z L Kazachkov Ⅰ Palm B | 2001 | Enhanced Heat Transfer2001，8，3： | 1 |
| 15 | Release of cytokines by human nasal epithelial cells and peripheral blood mononuclear cells infected with Mycoplasma pneumoniae显示文摘 | Kazachkov MY Hu PC Carson JL | 2002 | Exp Biol Med (Maywood)2002，227，5： | 1 |
| 16 | Release of cytokines by human nasal epithelial cells and peripheral blood monanuclear cells infected with Mycoplasma pneumoniae显示文摘 | Kazachkov MY Hu PC Carson JL | 2002 | J Exp Med2002，227，5： | 1 |
| 17 | Gas sensing properties of In2O3 and Au- doped films for detecting carbon monoxide in air 显示文摘 | Belysheva T V Kazachkov E A Gutman E E | 2001 | J Anal Chem2001，56，7： | 1 |
| 18 | A novel HPLC procedure for detection and quantification of aminoaeetone, a precursor of methylglyoxal, in biological samples 显示文摘 | KAZACHKOV M YU P H | 2005 | J Chromatogr B Analyt Technol Biomed Life Sci2005，824，12： | 1 |
| 19 | Evidence for in vivo scavenging by aminoguanidine of formaldehyde produced via semicarbazide-sensitive amine oxidase-mediated deamina- tion 显示文摘 | KAZACHKOV M CHEN K BABIY S | 2007 | J Pharmacol Exp Ther2007，322，3： | 1 |
| 20 | Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine 显示文摘 | GUBISNE-HABERLE D HILL W KAZACHKOV M | 2004 | J Pharmacol Exp Ther2004，310，3： | 1 |
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